Objective: Evidence suggests that serum uric acid (UA) is a relevant and independent risk factor for cardiovascular disease. A better understanding of its relationship with cardiometabolic and subclinical hypertensive target organ damage (TOD) profile may help clarify this association. Design and method: We studied 660 consecutive never treated newly diagnosed essential HTN patients (51 ± 13 years, 46.8% female), free of diabetes and overt cardiovascular or other systemic disease, who visited our antihypertensive outpatient clinic. All patients underwent office, home and 24-hour ABPM measurements. The evaluation of target organ damages (TODs) was performed according to ESH Guidelines. Subjects with isolated office hypertension were excluded from the study. Based on gender-specific upper limit of normal for uricemia (6.1 for females and 7.2 mg/dl for males), study population was categorized in normouricemic (NU, n = 583) and hyperuricemic (HU, n = 77). Results: Prevalence of hyperuricemia was 11.7%, significantly higher in males (16.2% vs. 6.5%, p < 0.001). While there was no difference regarding age, all indices of general and abdominal obesity, including metabolic syndrome, all classical cardiovascular risk factors, including office and 24hr blood pressure and target organ damage severity were more prevalent in HU group (table).Conclusions: Essential hypertensive hyperuricemic patients presents an adverse cardiometabolic profile which is reflected in the target organ damage prevalence and severity. Large scale lifestyle and/or medical intervention studies to assess the impact of lowering hyperuricemia in hypertensive patients are warranted.
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