PP.16.21

Objective: To evaluate serum adiponectin levels in hypertensive patients with abdominal obesity. Design and method: We examined 183 hypertensive patients aged 30–55 years (mean age 45,14+/-0,43) with abdominal obesity (waist circumference above 94 cm in men and above 80 cm in women). 41% of patients were overweight (BMI 28,01+/-0,14 kg/m2), 59% were obese (BMI 35,11+/-0,36 kg/m2). 20 normotensive subjects with BMI < 25 kg/m2 formed control group. Adiponectin and insulin levels were evaluated by ELISA (DRG, USA). Fasting plasma glucose was detected by standard biochemical method. To evaluate insulin resistance Homeostasis Model Assessment was used (HOMA-IR). Results: There were no difference in mean BMI between males and females with abdominal obesity. Serum adiponectin level in patients with abdominal obesity was 19,32+/-1,24 ng/ml, and it did not vary among overweight and obese patients (20,42+/-1,21 ng/ml, 19,19+/-0,74 ng/ml, accordingly, p > 0,05), but in healthy controls it was higher 25,93+/-0,88 ng/ml, p < 0,05. Plasma adiponectin levels were higher in women than in men (21,74+/-0,74 ng/ml and 16,62+/-1,01 ng/ml accordingly, p = 0,001). HOMA-IR in patients with abdominal obesity was higher in BMI 30 kg/m2 than in overweight subjects (6,30+/-0,69 vs 3,41, p = 0,001) and in hypertensive patients when compared to normotensive subjects (5,82+/-0,67 vs 4,02, p = 0,008). Correlations were seen between HOMA-IR and waist circumference (r = 0,42, p = 0,0001), BMI (r = 0,40, p = 0,0001) and adiponectin level (r = -0,21, p = 0,003). Correlations were also present between adiponectin level and BMI (r = -0,2, p = 0,004) and waist circumference (r = -0,3, p = 0,004). We also revealed correlations between adiponectin level and age (r = 0,3, p = 0,001), family history of cardiovascular disease and obesity (r = -0,2, p = 0,012). Conclusions: In abdominal obesity adiponectin levels do not differ between hypertensive and normotensive subjects. Adiponectin level is higher in healthy control group than in obese patients as well as women than in men. Insulin resistance index (HOMA-IR) is higher in obese hypertensive patients than in overweight and normotensive subjects.