Objective: The objective of this study is to analyse the effect and side-effects of combination therapy of Olmesartan/Amlodipine in the treatment of Resistant Hypertension. Design and method: Querstionaire based cross sectional study among patients with Resistant Hypertension according to the 2013 ESC Guideline for management of Hypertension. Study was carried out in 64 patients admitted with history and holter blood pressure monitor evidence of Resistant Hypertension in the Cardiology Department between 1 st of July 2013 and 31 st of July 2014. Patients who fulfilled the inclusion criteria by the initial holter blood pressure moniter were started on combination therapy with Olmesartan/Amlodipine along with diuretic and Beta-blocker. Patients were analysed with control questionaire and holter blood pressure monitor after 3 months for the effect and side-effects and the circadian rythm of blood pressure control. Results: From the study it was seen that 45 (70.31%) of the patients included in the study had reached optimal control of blood pressure. 10 patients (15.64%) had non optimal control of blood pressure, 3 patients (4.68%) stopped the treatment due to pedal oedema. 6 patients (9.37%) patients continued to be with resistant hypertension inspite of our maximal therapy. From the initial holter blood pressure monitering it was observed that 19 patients (30%) included in the study were non- dippers and after the therapy with Olmesartan/Amlodipine combination it was found that only 7 patients (10.93%) were non- dippers. Conclusions: From our study we observed that the combination therapy with Olmesartan/Amlodipine in patients with Resistant Hypertension has high efficacy and minimal side-effects with good circadian control of Hypertension.
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