Prediabetes and the Risk of Atrial Fibrillation and Heart Failure: a Propensity-Matched Analysis in a Real-World Cohort

Although diabetes is a recognized risk factor for atrial fibrillation (AF) and heart failure (HF), the cardiovascular consequences of prediabetes remain unclear, particularly regarding AF subtypes and HF development. This study aimed to evaluate the association of prediabetes with new-onset AF, including subtype specificity, and its association with HF development using an international, real-world cohort. We analyzed de-identified electronic health records from the TriNetX network, including adults aged 18-79 years without prior AF or atrial flutter. Prediabetes was defined as hemoglobin A1c (HbA1c) 5.7-6.4