1. Ejaculation that always or nearly always occurs prior to or within about 1 minute of vaginal penetration (lifelong PE) or a clinically significant and bothersome reduction in latency time, often to about 3 minutes or less (acquired PE). 2. T he inability to delay ejaculation on all or nearly all vaginal penetrations. 3. Negative personal consequences, such as distress, bother, frustration, and/or the avoidance of sexual intimacy. Qeios · Definition, October 1, 2019