Prior Cholecystectomy May Identify a Biologically Aggressive Subset of RAS-mutated Proximal Colon Cancer: A 13-Year Retrospective Cohort Study

Cholecystectomy (CCY) may influence the colorectal cancer (CRC) outcomes in a location-specific manner. We investigated the association between CCY history and RAS mutations in CRC, focusing on tumor location. We retrospectively analyzed 1,340 patients with CRC diagnosed between 2012 and 2024, with an available RAS mutation status. Patients were classified into proximal and distal groups for analysis. The survival outcomes were compared using multivariate Cox proportional hazard regression models. CCY was associated with a higher RAS mutation prevalence in proximal CRC (58