Proposed Revised Criteria for the Classification of Acute Myeloid Leukemia. A Report of the French-American-British Cooperative Group.

Position Papers1 October 1985Proposed Revised Criteria for the Classification of Acute Myeloid LeukemiaA Report of the French-American-British Cooperative GroupJOHN M. BENNETT, M.D., DANIEL CATOVSKY, M.D., MARIE T. DANIEL, M.D., GEORGE FLANDRIN, M.D., DAVID A. G. GALTON, M.D., HARVEY R. GRALNICK, M.D., CLAUDE SULTAN, M.D.JOHN M. BENNETT, M.D.Search for more papers by this author, DANIEL CATOVSKY, M.D.Search for more papers by this author, MARIE T. DANIEL, M.D.Search for more papers by this author, GEORGE FLANDRIN, M.D.Search for more papers by this author, DAVID A. G. GALTON, M.D.Search for more papers by this author, HARVEY R. GRALNICK, M.D.Search for more papers by this author, CLAUDE SULTAN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-103-4-620 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe first proposals for the morphologic classification of the acute leukemias by the French-American-British (FAB) group (1) were put forward in the hope that they might serve as a basis for a generally acceptable system of classification. Such a system would permit comparisons between series of cases, show prognostic differences between different categories, and provide a framework of reference for persons working in different biological disciplines who use material from patients with leukemia.In the last 7 years the FAB proposals have been accepted by many groups involved in cooperative clinical trials with both acute myeloid leukemia and acute lymphoblastic...References1. BENNETTCATOVSKYDANIEL JDM. Proposals for the classification of the acute leukaemias: French-American-British Cooperative Group. Br J Haematol. 1976;33:451-8. CrossrefMedlineGoogle Scholar2. SECOND INTERNATIONAL WORKSHOP ON CHROMOSOMES IN LEUKEMIA, 1979. Morphological analysis of acute promyelocytic (M3) and t(8;21). Cancer Genet Cytogenet. 1980;2:97-8. CrossrefGoogle Scholar3. THIRD INTERNATIONAL WORKSHOP ON CHROMOSOMES IN LEUKEMIA, 1980. Clinical significance of chromosomal abnormalities in acute lymphoblastic leukemia. Cancer Genet Cytogenet. 1981;4:111-37. CrossrefMedlineGoogle Scholar4. FOURTH INTERNATIONAL WORKSHOP ON CHROMOSOMES IN LEUKEMIA, 1982. A prospective study of acute non-lymphocytic leukemia: correlation of morphology and karyotype. Cancer Genet Cytogenet. 1984;11:246-360. Google Scholar5. MERTELSMANNTZVI THALERLO RHT. Morphological classification, response to therapy and survival in 263 adult patients with acute nonlymphoblastic leukemia. Blood. 1980;56:773-81. CrossrefMedlineGoogle Scholar6. VAN RHENENVERHULSTHUIJGENSLANGENHUIJSEN DJPM. Maturation index: a contribution to quantification in the FAB classification of acute leukemia. Br J Haematol. 1980;46:581-6. CrossrefMedlineGoogle Scholar7. STAVEM P. The blasted immature cells in the bone marrow [Letter]. Scand J Haematol. 1983;30:492-3. CrossrefMedlineGoogle Scholar8. AMAKIHATTORIBENNETT IKJ. FAB classification of acute leukemias correlating with response to chemotherapy. Nippon Ketsueki Gakkai Zasshi. 1984;47:206-38. MedlineGoogle Scholar9. BENNETTCATOVSKYDANIEL JDM. The morphological classification of acute lymphoblastic leukaemia: concordance among observers and clinical correlations. Br J Haematol. 1981;47:553-61. CrossrefMedlineGoogle Scholar10. BENNETTCATOVSKYDANIEL JDM. Proposals for the classification of the myelodysplastic syndromes. Br J Haematol. 1982;51:189-99. CrossrefMedlineGoogle Scholar11. SULTANDEREGNAUCOURTKO CJY. Distribution of 250 cases of acute myeloid leukaemia (AML) according to the FAB classification and response to therapy. Br J Haematol. 1981;47:545-51. CrossrefMedlineGoogle Scholar12. BENNETTCATOVSKYDANIEL JDM. A variant form of hypergranular promyelocytic leukaemia (M3) [Letter]. Br J Haematol. 1980;44:169-70. CrossrefMedlineGoogle Scholar13. YAMLICROSBY LCW. Cytochemical identification of monocytes and granulocytes. Am J Clin Pathol. 1971;55:283-90. CrossrefMedlineGoogle Scholar14. PARRYCHANDANSHAHANI RRK. A rapid and sensitive assay for muramidase. Proc Soc Exp Biol Med. 1965;119:384-6. CrossrefMedlineGoogle Scholar15. LEDER L. Akute myelo-monozytare Leukamie mit atypischen Naphthol-AS-D-Chloroacetat-Esterase-positivenEosinophilen. Acta Haematol. 1970;44:52-62. CrossrefMedlineGoogle Scholar16. BERGERBERNHEIMDANIELVALENSIFLANDRIN RAMFG. t(15;17) translocation in acute promyelocytic leukaemia (M3) and cytological "M3-variant." Nouv Rev Fr Hematol. 1981;23:27-38. Google Scholar17. BERGERBERHEIMDANIELVALENSISIGAUXFLANDRIN RAMFFG. Cytologic characterization and significance of normal karyotypes in t(8;21) acute myeloblasts leukemia. Blood. 1982;59:171-8. CrossrefMedlineGoogle Scholar18. BERGERBERNHEIMSIGAUXDANIELVALENSIFLANDRIN RAFMFG. Acute monocytic leukemia chromosome studies. Leuk Res. 1982;6:17-26. CrossrefMedlineGoogle Scholar19. GOLOMBROWLEYVARDIMANTESTABUTLER HJJJA. "Microgranular" acute promyelocytic leukemia: a distinct clinical, ultrastructural, and cytogenetic entity. Blood. 1980;55:253-9. CrossrefMedlineGoogle Scholar20. OSHIMURAOHYASHIKIMORITERADATAKAKU MKMHF. Cytogenetic and hematologic findings in acute myelogenous leukemia, M2 according to the FAB classification. Gann. 1982;73:212-6. MedlineGoogle Scholar21. ARTHURBLOOMFIELD DC. Partial deletion of the long arm of chromosome 16 and bone marrow eosinophilia in acute nonlymphocytic leukemia: a new association. Blood. 1983;61:994-8. CrossrefMedlineGoogle Scholar22. LE BEAULARSONBITTERVARDIMANGOLOMBROWLEY MRMJHJ. Association of an inversion of chromosome 16 with abnormal marrow eosinophils in acute myelomonocytic leukemia. N Engl J Med. 1983;309:603-6. CrossrefGoogle Scholar23. DEN OTTOLANDERTE VELDEBREDEROO GJP. Megakaryoblastic leukaemia (acute myelofibrosis): a report of three cases. Br J Haematol. 1979;42:9-20. CrossrefMedlineGoogle Scholar24. BRETON-GORIUSGOURDINREYES JMF. Ultrastructure of the leukemic cell. In: CATOVSKY D, ed. The Leukemic Cell. Edinburgh, Scotland: Churchill Livingstone; 1981:87-128. Google Scholar25. BAINCATOVSKYO'BRIEN BDM. Megakaryoblastic leukemia presenting as acute myelofibrosis—a study of four cases with the platelet-peroxidase reaction. Blood. 1981;58:206-13. CrossrefMedlineGoogle Scholar26. SULTANSIGAUXIMBERTREYES CFMF. Acute myelodysplasia with myelofibrosis: a report of eight cases. Br J Haematol. 1981;49:11-6. CrossrefMedlineGoogle Scholar27. VAN DER REIJDENVAN RHENENLANSDORP HDP. A comparison of surface marker analysis and FAB classification in acute myeloid leukemia. Blood. 1983;61:443-8. CrossrefMedlineGoogle Scholar28. VAINCHENKERDESCHAMPSBASTIN WJJ. Two monoclonal antiplatelet antibodies as markers of human megakaryocyte maturation: immunofluorescent staining and platelet peroxidase detection in megakaryocyte colonies and in in vivo cells from normal and leukemia patients. Blood. 1982;59:514-21. CrossrefMedlineGoogle Scholar29. NEEDLEMANBURNSDICKARMITAGE SCFJ. Hypoplastic acute leukemia. Cancer. 1981;48:1410-4. CrossrefMedlineGoogle Scholar30. HOWEBLOOMFIELDMCKENNA RCR. Hypocellular acute leukemia. Am J Med. 1982;72:391-5. CrossrefMedlineGoogle Scholar31. CATOVSKYDECARDULLOO'BRIEN DSLM. Cytochemical markers of differentiation in acute leukemia. Cancer Res. 1981;41( 11 pt 2):4824-32. MedlineGoogle Scholar32. PARKINARTHURABRAMSON JDC. Acute leukemia associated with the t(4;11) chromosome rearrangement: ultrastructural and immunologic characteristics. Blood. 1983;119:1321-31. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Rochester, New York; London England Paris and Creteil France Bethesda Maryland▸From the University of Rochester Cancer Center, University of Rochester School of Medicine and Dentistry, Rochester, New York; Medical Research Council Leukaemia Unit, Royal Postgraduate Medical School, London, England; Institut de Recherches sur les Leucemies et les Maladies du Sang, Hopital Saint-Louis, Paris, France; Hematology Service, National Institutes of Health, Bethesda, Maryland; and Service Central d'Hematologie-Immunologie, Hopital Henri Mondor, Creteil, France. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByRepeat to gene expression ratios in leukemic blast cells can stratify risk prediction in acute myeloid leukemiaCircular RNAs in acute myeloid leukemiaA circular RNA derived from PLXNB2 as a valuable predictor of the prognosis of patients with acute myeloid leukaemiaPRICKLE1, a Wnt/PCP signaling component, is overexpressed and associated with inferior prognosis in acute myeloid leukemiaThe prognostic impact of Wilms tumor-1 polymorphism (rs16754) and human myeloid inhibitory C-type lectin-like receptor expression in cytogenetically normal-acute myeloid leukemiaIdentification of Protein Biomarker Signatures for Acute Myeloid Leukemia (AML) Using Both Nontargeted and Targeted ApproachesIntegrated Human and Murine Clinical Study Establishes Clinical Efficacy of Ruxolitinib in Chronic Myelomonocytic LeukemiaClinical implication and prognostic significance of FLT3-ITD and ASXL1 mutations in Egyptian AML patients: A single-center studyAcute promyelocytic leukemia (APL) in very old patients: real-life behind protocolsMonosomal karyotype as an adverse risk factor for inferior survivals in children with acute myeloid leukemiaDiagnosis of Variant Translocations in Acute Promyelocytic LeukemiaIntegrative Genomic Analysis of Pediatric Myeloid-Related Acute Leukemias Identifies Novel Subtypes and Prognostic IndicatorsAdvances in acute myeloid leukemiaTreatment of acute erythroleukaemia with high‐dose cytarabine in a cat with feline leukaemia virus infectionObituary Harvey R. Gralnick, MD (1937–2020)Investigation of the Osteopontin isoforms expression in patients with acute myeloid leukemiaPrognosis and Outcome of Fit Patients with Acute Myeloid Leukemia in KuwaitUptake of carbon nanodots into human AML cells in comparison to primary hematopoietic cellsHigh expression of long noncoding RNA NORAD is associated with poor clinical outcomes in non-M3 acute myeloid leukemia patientsExpression and prognostic relevance of long noncoding RNAs CRNDE and AOX2P in adult acute myeloid leukemiaESCCABase project: A repository in progressCytogenetic influence on prognosis in acute promyelocytic leukaemia: A cohort study in VietnamChronic interleukin-1 exposure triggers selection for Cebpa -knockout multipotent hematopoietic progenitorsDelineation of Molecular Lesions in Acute Myeloid Leukemia Patients at Diagnosis: Integrated Next Generation Sequencing and Cytogenomic StudiesCytogenetics of Pediatric Acute Myeloid Leukemia: A Review of the Current KnowledgePrognostic Prediction of Cytogenetically Normal Acute Myeloid Leukemia Based on a Gene Expression ModelReferencesCell signaling pathways as molecular targets to eliminate AML stem cellsIntensive versus less-intensive antileukemic therapy in older adults with acute myeloid leukemia: A systematic reviewNovel therapeutic targets for chronic myelomonocytic leukemiaControversies in the recent (2016) World Health Organization classification of acute myeloid leukemiaCharacteristics and outcome of patients with acute myeloid leukaemia and t(8;16)(p11;p13): results from an International Collaborative Study*Solasonine Suppresses the Proliferation of Acute Monocytic Leukemia Through the Activation of the AMPK/FOXO3A AxisShort loop functional commonality identified in leukaemia proteome highlights crucial protein sub-networksGenomic Landscape and Clonal Evolution of AMLManagement of Acute Promyelocytic LeukemiaLeukemia cutis in a medical center in southern Taiwan: A retrospective study of 42 patientsNext-generation sequencing reveals gene mutations landscape and clonal evolution in patients with acute myeloid leukemiaAssociation of kinesin family member 2A with increased disease risk, deteriorative clinical characteristics, and shorter survival profiles in acute myeloid leukemiaTrdmt1 3'-untranslated region functions as a competing endogenous RNA in leukemia HL-60 cell differentiationDisseminated intravascular coagulopathy in non-promyelocytic acute myeloid leukemia: Incidence, clinical and laboratory features and prognostic significanceAcute erythroid leukemia is enriched in NUP98 fusions: a report from the Children’s Oncology GroupGene mutational analysis by NGS and its clinical significance in patients with myelodysplastic syndrome and acute myeloid leukemiaReductive regulation of BECN1 gene in adult Egyptian patients with do novo AMLSecondary chronic myeloid leukemia following acute myeloid leukemia treated with autologous hematopoietic stem cell transplantation: a case reportDelineation of target expression profiles in CD34+/CD38− and CD34+/CD38+ stem and progenitor cells in AML and CMLEarly Mortality in Children and Adolescents with Acute Promyelocytic Leukemia: Experience of the Boldrini Children’s CenterP‐glycoprotein and multidrug resistance‐associated protein‐1 expression in acute myeloid leukemia: Biological and prognosis implicationsOutcome of older (≥70 years) APL patients frontline treated with or without arsenic trioxide—an International Collaborative StudyFc gamma receptor expression serves as prognostic and diagnostic factor in AMLOverexpression of long noncoding RNA HOXA‐AS2 predicts an adverse prognosis and promotes tumorigenesis via SOX4/PI3K/AKT pathway in acute myeloid leukemiaCD105 (endoglin) as risk marker in AML patients undergoing stem cell transplantationWT1, PRAME, and PR3 mRNA Expression in Acute Myeloid Leukemia (AML)Çukurova Bölgesinde akut lenfoblastik lösemili çocuklarda vasküler endotelyal büyüme faktörü (VEGF-C) ve temel fibroblast büyüme faktörü (bFGF) plazma ekspresyonu ve metilasyon seviyeleriCutaneous Myeloid Sarcoma Mimicking Skin Cancer in Aleukemic Patients: a Diagnostic Challenge in SurgeryCritical Upper Airway Obstruction as the First Symptom of Acute Myeloid Leukemia—An Anesthesiologic ReminderNormal myeloid progenitor cell subset-associated gene signatures for acute myeloid leukaemia subtyping with prognostic impactHarlequin cell: Ubiquitous or pathognomic?Intravoxel Incoherent Motion Diffusion-weighted MRI of Infiltrated Marrow for Predicting Overall Survival in Newly Diagnosed Acute Myeloid LeukemiaIdentification of CD318 (CDCP1) as novel prognostic marker in AMLPeripheral blood blast rate of clearance is an independent predictor of clinical response and outcomes in acute myeloid leukaemiaModifications of H3K4 methylation levels are associated with DNA hypermethylation in acute myeloid leukemiaA‐kinase interacting protein 1 might serve as a novel biomarker for worse prognosis through the interaction of chemokine (C‐X‐C motif) ligand 1/chemokine (C‐X‐C motif) ligand 2 in acute myeloid leukemiaCorrelation of miR‐181a and three HOXA genes as useful biomarkers in acute myeloid leukemiaAcute Leukemia of Myeloid, Lymphoid, and Ambiguous Lineage and Related MalignanciesCytogenetics/cytogenomicsAcute leukemiasIsotretinoin is active in the initial management of acute pro-myelocytic leukemiaThe power and potential of integrated diagnostics in acute myeloid leukaemia Circ_0002232 Acts as a Potential Biomarker for AML and Reveals a Potential ceRNA Network of Circ_0002232/miR-92a-3p/PTEN Anti-leukemic effects of simvastatin on NRASG12D mutant acute myeloid leukemia cellsCD105 (Endoglin) as negative prognostic factor in AMLAssociations of PGK1 promoter hypomethylation and PGK1-mediated PDHK1 phosphorylation with cancer stage and prognosis: a TCGA pan-cancer analysisChronic Myelomonocytic Leukemia: Insights into Biology, Prognostic Factors, and TreatmentHuman-level recognition of blast cells in acute myeloid leukaemia with convolutional neural networksDOK6 promoter methylation serves as a potential biomarker affecting prognosis in de novo acute myeloid leukemiaCytogenetic profile of a representative cohort of young adults with de novo acute myéloblastic leukaemia in MoroccoThe Mechanism of Anti–PD-L1 Antibody Efficacy against PD-L1–Negative Tumors Identifies NK Cells Expressing PD-L1 as a Cytolytic EffectorPriming with GM-CSF instead of G-CSF enhances CAG-induced apoptosis of acute monocytic leukemia cells in vitroSerous retinal detachment as an initial presentation of childhood acute myeloid leukemiaKnockdown of Long Noncoding RNA Plasmacytoma Variant Translocation 1 with Antisense Locked Nucleic Acid GapmeRs Exerts Tumor-Suppressive Functions in Human Acute Erythroleukemia Cells Through Downregulation of C-MYC ExpressionNot Only Mutations Matter: Molecular Picture of Acute Myeloid Leukemia Emerging from Transcriptome StudiesAssociation of Leukemia Cutis With Survival in Acute Myeloid LeukemiaThe Neuropilin-1 Ligand, Sema3A, Acts as a Tumor Suppressor in the Pathogenesis of Acute LeukemiaFeline Leukaemia Virus Associated with Leukaemia in Cats in Santa Catarina, BrazilDynamic changes in the level of WT1 as an MRD marker to predict the therapeutic outcome of patients with AML with and without allogeneic stem cell transplantationChronic Myelomonocytic Leukemia: 2018 Update to Prognosis and TreatmentMicroRNA-335/ID4 dysregulation predicts clinical outcome and facilitates leukemogenesis by activating PI3K/Akt signaling pathway in acute myeloid leukemiaCircular RNA of vimentin expression as a valuable predictor for acute myeloid leukemia development and prognosisCanonical WNT Signaling Pathway is Altered in Mesenchymal Stromal Cells From Acute Myeloid Leukemia Patients And Is Implicated in BMP4 Down-RegulationGenomic subtyping and therapeutic targeting of acute erythroleukemiaPrognostic Value of Genetic Alterations in Elderly Patients with Acute Myeloid Leukemia: A Single Institution ExperienceMutational spectrum and associations with clinical features in patients with acute myeloid leukaemia based on next‑generation sequencingACUTE MYELOID LEUKAEMIA, MIXED PHENOTYPE ACUTE LEUKAEMIA, THE MYELODYSPLASTIC SYNDROMES AND HISTIOCYTIC NEOPLASMSIdentification of novel serum biomarker for the detection of acute myeloid leukemia based on liquid chromatography-mass spectrometryWheat Germ Agglutinin as a Potential Therapeutic Agent for LeukemiaMicroRNA expression profiles discriminate childhood T‐ from B‐acute lymphoblastic leukemiaComparison of Peripheral Blast Clearance and Day 14 Bone Marrow Biopsy in Predicting Remission Status and Survival After 7+3 Induction in Acute Myeloid LeukemiaAdditional prognostic impact of the percentage of erythroid cells in the bone marrow of patients with myelodysplastic syndromesPreliminary study on the role of miR‑148a and DNMT1 in the pathogenesis of acute myeloid leukemiaAcute Myeloid Leukemia: An UpdateAllogeneic Hematopoietic Stem Cell Transplantation for Acute Myeloid LeukemiaRate of differentiation syndrome in patients based on timing of initial all-trans retinoic acid administrationAnxiety and depression predict unfavorable survival in acute myeloid leukemia patientsAcute Monoblastic Leukemia with t(11;17)(q23;q21): Fusion of the KMT2A ( MLL ) and MLLT6 ( AF17 ) GenesAcute myeloid leukemia with t(16;16)(p13.1;q22)/CBFB-MYH11Current Management and Recent Advances in the Treatment of Chronic Myelomonocytic LeukemiaMaintenance Therapy With Interleukin-2 for Childhood AMLNext-generation sequencing-based genetic landscape and its clinical implications for Chinese acute myeloid leukemia patientsDysregulation of miR-200s clusters as potential prognostic biomarkers in acute myeloid leukemiaCurrent status and trends in the diagnostics of AML and MDSIdentification of the novel deletion-type PML-RARA mutation associated with the retinoic acid resistance in acute promyelocytic leukemiaExpression Analysis of PVT1 , CCDC26, and CCAT1 Long Noncoding RNAs in Acute Myeloid Leukemia PatientsIncreased Survival for Children With Acute Myeloid Leukemia Results From Improved Postrelapse TreatmentGenital ulcers as diagnostic clue for acute myeloid leukaemiaHexosamine Biosynthetic Pathway Inhibition Leads to AML Cell Differentiation and Cell DeathClinical diagnosis of adult patients with acute megakaryocytic leukemiaIMiDs mobilize acute myeloid leukemia blasts to peripheral blood through downregulation of CXCR4 but fail to potentiate AraC/Idarubicin activity in preclinical models of non del5q/5q- AMLTSC gene expression in the newly diagnosed Egyptian acute leukemia patientsMicroRNA‐9 suppresses cancer proliferation and cell cycle progression in acute lymphoblastic leukemia with inverse association of neuropilin‐1TET2 expression is a potential prognostic and predictive biomarker in cytogenetically normal acute myeloid leukemiaKnockdown of LncRNA‐UCA1 suppresses chemoresistance of pediatric AML by inhibiting glycolysis through the microRNA‐125a/hexokinase 2 pathwayPARP-1 Overexpression as an Independent Prognostic Factor in Adult Non-M3 Acute Myeloid LeukemiaProteomics in Acute Myeloid LeukemiaRole of Genetic Analysis in New Treatments of Acute Myeloid LeukemiaSETBP1 mutations in Chinese patients with acute myeloid leukemia and myelodysplastic syndromeLow Expression of Long Noncoding RNA IRAIN Is Associated with Poor Prognosis in Non-M3 Acute Myeloid Leukemia PatientsThe Synonymous Isocitrate Dehydrogenase 1 315C>T SNP Confers an Adverse Prognosis in Egyptian Adult Patients with NPM1-/CEBPA-Negative Acute Myeloid LeukemiaOutcomes of Adolescents and Young Adults With Acute Myeloid Leukemia Treated in a Single Latin American CenterClinical characteristics and outcome of invasive fungal infections in pediatric acute myeloid leukemia patients in a medical center in TaiwanClinical challenges in de novo pediatric acute myeloid leukemiaPrognostic analysis according to the 2017 ELN risk stratification by genetics in adult acute myeloid leukemia patients treated in the Japan Adult Leukemia Study Group (JALSG) AML201 studyPediatric CancersSilencing of HMGA2 reverses retardance of cell differentiation in human myeloid leukaemiaCytokines and soluble HLA-G levels in bone marrow stroma and their association with the survival rate of patients exhibiting childhood T-cell acute lymphoblastic leukemiaPhosphoprotein DIGE profiles reflect blast differentiation, cytogenetic risk stratification, FLT3/NPM1 mutations and therapy response in acute myeloid leukaemiaDistinct gene alterations with a high percentage of myeloperoxidase-positive leukemic blasts in de novo acute myeloid leukemiaACUTE LEUKAEMIA IMMUNOPHENOTYPING BY IMMUNOHISTOCHEMISTRY IN BONE MARROW TREPHINE BIOPSY SECTIONSDiagnosis and Treatment of Acute Myeloid Leukemia in ChildrenLeukämien und LymphomeMolecular Basis of Lymphoid and Myeloid DiseasesAcute Myeloid LeukemiaA phase 1/2 study of rigosertib in patients with myelodysplastic syndromes (MDS) and MDS progressed to acute myeloid leukemiaLow Expression of FUS1 Is Negatively Correlated with miR-378 and May Predict Adverse Prognoses in Acute Myeloid LeukemiaImprovement of treatment outcome over 2 decades in children with acute myeloid leukemiaGene expression profiling of acute myeloid leukemia samples from adult patients with AML-M1 and -M2 through boutique microarrays, real-time PCR and droplet digital PCRGenotype-outcome correlations in pediatric AML: the impact of a monosomal karyotype in trial AML-BFM 2004Clinical impact of KMT2C and SPRY4 expression levels in intensively treated younger adult acute myeloid leukemia patientsAn analysis of 97 previously diagnosed de novo adult acute erythroid leukemia patients following the 2016 revision to World Health Organization classificationHigh Tim-3 expression on AML blasts could enhance chemotherapy sensitivityReduced expression of chemerin is associated with poor clinical outcome in acute myeloid leukemiaCharacteristics and outcome of patients with therapy-related acute promyelocytic leukemia front-line treated with or without arsenic trioxide70 years of the JCP -highly cited papers: Proposals for the classification of chronic (mature) B and T lymphoid leukaemiasCellular and plasma nitrite levels in myeloid leukemia: a pathogenetic decreasePharmacometabolomics identifies dodecanamide and leukotriene B4 dimethylamide as a predictor of chemosensitivity for patients with acute myeloid leukemia treated with cytarabine and anthracyclineClinical and prognostic significance of eosinophilia and inv(16)/t(16;16) in pediatric acute myelomonocytic leukemia (AML-M4)Mixed-phenotype acute leukemia: state-of-the-art of the diagnosis, classification and treatmentCirculating tight junction proteins mirror blood-brain barrier integrity in leukaemia central nervous system metastasisReprogramming acute myeloid leukemia into sensitivity for retinoic-acid-driven differentiationEpigenetic dysregulation of ID4 predicts disease progression and treatment outcome in myeloid malignanciesp15Ink4b Loss of Expression by Promoter Hypermethylation Adds to Leukemogenesis and Confers a Poor Prognosis in Acute Promyelocytic Leukemia PatientsGene-expression-based monocyte-specific clustering of acute myeloid leukemias reveals novel associationsEnumerating bone marrow blasts from nonerythroid cellularity improves outcome prediction in myelodysplastic syndromes and permits a better definition of the intermediate risk category of the Revised International Prognostic Scoring System (IPSS-R)Significance of OCT1 Expression in Acute Myeloid LeukemiaBone marrow evaluation for diagnosis and monitoring of acute myeloid leukemiaThe plasma lipidome in acute myeloid leukemia at diagnosis in relation to clinical disease featuresDetailed Characterization of Mesenchymal Stem/Stromal Cells from a Large Cohort of AML Patients Demonstrates a Definitive Link to Treatment OutcomesChemotherapy-induced hypomethylation of N-myc downstream-regulated gene 4 in the bone marrow of patients with acute myeloid leukemiaImpact of FAB classification on predicting outcome in acute myeloid leukemia, not otherwise specified, patients undergoing allogeneic stem cell transplantation in CR1: An analysis of 1690 patients from the acute leukemia working party of EBMTCombination of cytogenetic classification and MRD status correlates with outcome of autologous versus allogeneic stem cell transplantation in adults with primary acute myeloid leukemia in first remissionLow NKD1 expression predicts adverse prognosis in cytogenetically normal acute myeloid leukemiaThe Nature of Leukaemia, Cytology, Cytochemistry and the Morphological Classification of Acute LeukaemiaThe Myelodysplastic Syndromes and the Myelodysplastic/Myeloproliferative NeoplasmsDown-regulation of pseudogene Vimentin 2p is associated with poor outcome in de novo acute myeloid leukemiaClinico Hematological Profile of Acute Promyelocytic LeukemiaTET2 and MEG3 promoter methylation is associated with acute myeloid leukemia in a Hainan populationRare Acute LeukemiasAcute promyelocytic leukaemia is highly frequent among acute myeloid leukaemias in Brazil: a hospital-based cancer registry study from 2001 to 2012Clinical Characteristics and Prognosis of 167 Cases of Acute ErythroleukemiaFrontline treatment of acute myeloid leukemia in adultsReduced ADAMTS-13 level negatively correlates with inflammation factors in plasma of acute myeloid leukemia patientsDownregulated stromal antigen 2 expression in de novo acute myeloid leukemia patientsMolecular Biology of LeukemiasHematological Malignancies, Leukemias, and LymphomasBlood Cell Morphology in Health and DiseaseExome sequencing identifies highly recurrent somatic GATA2 and CEBPA mutations in acute erythroid leukemiaSubtype-specific patterns of molecular mutations in acute myeloid leukemiaMolecular Mutations and Their Cooccurrences in Cytogenetically Normal Acute Myeloid LeukemiaCDH1 (E-cadherin) expression independently affects clinical outcome in acute myeloid leukemia with normal cytogeneticsPolymorphisms in lncRNA HOTAIR and Susceptibility to Acute Myeloid Leukemia in Iranian PatientsMinimal residual disease detection in Tunisian B-acute lymphoblastic leukemia based on immunoglobulin gene rearrangementsCoexistence of inversion 16 in chronic myeloid leukaemia in blast crisisAngiogenesis in hematological malignancy – Evaluated by dynamic contrast-enhanced MRIErythroleukemia shares biological features and outcome with myelodysplastic syndromes with excess blasts: a rationale for its inclusion into future classifications of myelodysplastic syndromesExpression of RANK-L and in part of PD-1 on blasts in patients with acute myeloid leukemia correlates with prognosisExpression of 4-1BB and its ligand on blasts correlates with prognosis of patients with AMLImmunoprofiling of leukemic stem cells CD34+/CD38−/CD123+ delineate FLT3/ITD-positive clonesSomatic mutations of isocitrate dehydrogenases 1 and 2 are prognostic and follow-up markers in patients with acute myeloid leukaemia with normal karyotypeAcute myeloid leukemia in children: the study of clinical and biological features and results of the treatment at the Department of pediatrics, Clinical Hospital Centre RijekaTargeted therapies in the treatment of adult acute myeloid leukemias: current status and future perspectivesmicroRNA-23a, -27a and -24 synergistically regulate JAK1/Stat3 cascade and serve as novel therapeuti