Introduction. Validity research into the OM-6 for a Dutch population, quality of life after grommets1 and the influence of ‘response shift bias’ was undertaken. Methods. Parents of 77 children with otitis media (OME) (age 12–36 months) completed the OM-6 (six items, seven-point scale). Quality of life domains concern physical suffering, hearing loss, speech impairment, emotional distress, activity limitations and caregiver concerns. The ‘global quality of life’ rating is performed on a 10-point visual analogue scale. The OM-6 is completed after the first visit to the ear, nose and throat (ENT) surgeon (pre-test 1) and around the time of surgery (pre-test 2). The post-test and the retrospective pre-test are scheduled 6 weeks after the intervention. Results. ‘Global quality of life’ and OM-6 ratings show a good correlation (R = −0.77, P < 0.01). Internal consistency of the OM-6 is satisfying (α = 0.79), responsiveness to clinical change is large (standardized response mean >0.8). Response shift bias is expressed by a difference between pre-test 1 and the retrospective pre-test (T = −3.3, P < 0.01). Before surgery, parents underestimate the seriousness of hearing loss (Z = −3.3, P < 0.05) and overestimate quality of life in general (Z = −3.6, P < 0.05). Conclusion. The OM-6 is valid for a Dutch population. Reported quality of life improves as a consequence of the intervention. The presence of response shift could be explained through adaptation to symptoms before surgery and changes in symptoms as a result of surgery, as well as an increase in knowledge of the consequences related to OME and hearing loss.