Radiation-induced NF-κB Activation and Expression of Its Down-Stream Target Genes As Biomarker of Radiation Quality

Activation of Nuclear Factor κB (NF-κB) and the resulting gene expression profile after exposure to different radiation qualities have been evaluated to a very limited extent. Therefore, the activation of NF-κB after exposure to low and high linear energy transfer (LET) radiation and the expression of its target genes was analyzed in human embryonic kidney (HEK) cells.