Radiation Therapy for Melanoma and Merkel Cell Carcinoma in the Contemporary Era

Over the last decade, the standard of care for patients with melanoma and Merkel cell carcinoma has undergone dramatic changes. These advancements have been largely driven by improvements in systemic therapy, altering treatment options for patients at every stage from localized to regional to distant disease. The optimal role of radiation therapy in this contemporary context is not always clear. Herein, the authors review the evidence regarding the role of radiation therapy for locoregional disease in these aggressive cutaneous malignancies in the modern era.