Radical Cyclisation Mediates the Synthesis of a New Base-Ribose Carbon Bridged Adenosine

P Lang,A Mayer,P Jung,D Tritsch, B Jean-Francois,A Burger

Tetrahedron Letters（2004）SCI 3区

Institut de Chimie

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摘要

Reaction of tributylstannyl, radical generated in situ with AIBN, with (2',5'-di-O-tert-butyldimethylsilyl-3'-C-ethynyl-beta-D-ribo-furanosyl)adenine (5) gave in 690% yield the new conformationally locked nucleosides 6 (EIZ). (C) 2004 Elsevier Ltd. All rights reserved.

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关键词

nucleoside,adenosine,deaminase,locked,conformation,radical,AIBN,tributyltin hydride,purinergic receptors

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