A specific form of cytochrome P450, P450 IIE1, active in ethanol oxidation, is known to be induced about 10-fold in rat liver following ethanol treatment. This isozyme of P450 participates effectively in the metabolic activation of precarcinogens, such asN-dimethylnitrosamines, and of solvents such as carbon tetrachloride and benzene. In the present investigation, two different polyclonal antisera against P450 IIEl were used in order to map the regional distribution of this P450 form in the rat central nervous system. The presence of P450 IIEl in various brain regions was confirmed by Western blot analysis.
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