Regulation of Fatty Acid Composition of Leukocytes by Exogenous N-Eicosapentaenoylethanolamine in Asthma

A study was conducted on the regulatory effect of N-eicosapentaenoylethanolamine (EPEA) on the modification of the fatty acid (FA) composition of leukocytes in patients with asthma, in comparison with the effect of eicosapentaenoic acid ethyl ester (EPEE). The FA composition of leukocytes was analyzed by gas chromatography-mass spectrometry, both with and without the addition of experimental compounds. It was found that under the influence of EPEA, the FA composition of leukocytes undergoes more substantial changes: compared to the effect of EPEE, the total level of saturated FAs was 10