Article1 November 1964Risk Factors in Coronary Heart DiseaseThe Framingham StudyWILLIAM B. KANNEL, M.D., F.A.C.P., THOMAS R. DAWBER, M.D., F.A.C.P., GARY D. FRIEDMAN, M.D., WILLIAM E. GLENNON, M.S., PATRICIA M. MCNAMARAWILLIAM B. KANNEL, M.D., F.A.C.P.Search for more papers by this author, THOMAS R. DAWBER, M.D., F.A.C.P.Search for more papers by this author, GARY D. FRIEDMAN, M.D.Search for more papers by this author, WILLIAM E. GLENNON, M.S.Search for more papers by this author, PATRICIA M. MCNAMARASearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-61-5-888 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAt Framingham, Massachusetts, the National Heart Institute has been following 5,127 men and women aged 30 to 60 years in a study of factors related to the development of coronary heart disease (CHD) and hypertension. Data for a decade of follow-up studies of this population are available for analysis.From a study of those who have developed disease under observation in comparison to those who have remained free of the disease, factors of risk and susceptible individuals have been identified. The factors associated with excess risk that have been identified are: serum cholesterol level, blood pressure, cigarette smoking, vital capacity,...References1. GORDONMOORESHURTLEFFDAWBER TFEDTR: Some methodologic problems in the long-term study of cardiovascular disease: observations on the Framingham Study. J. Chron. Dis. 10: 186, 1959. CrossrefGoogle Scholar2. KANNELDAWBERKAGANREVOTSKIESTOKES WBTRANJ: Factors of risk in the development of coronary heart disease—six-year follow-up experience: The Framingham Study. Ann. Intern. Med. 55: 33, 1961. LinkGoogle Scholar3. KAHN HA: A method for analyzing longitudinal observations on individuals in the Framingham Heart Study. Proceedings of the Social Statistics Section of the American Statistical Association, 1961. Google Scholar4. DELALLAGOFMAN OFJW: Ultracentrifugal analysis of serum lipoprotein, in Methods of Biochemical Analysis, vol. 1, edited by GLICK, D., Interscience, New York, 1954, pp. 459-478. Google Scholar5. ABELLLEVYBRODIEKENDALL LLBBBBFE: A simplified method for estimation of total cholesterol in serum and demonstration of its specificity. J. Biol. Chem. 195: 357, 1952. CrossrefMedlineGoogle Scholar6. YOUNGBURGYOUNGBURG GEMV: Phosphorus metabolism; system of blood phosphorus analysis. J. Lab. Clin. Med. 16: 158, 1930. Google Scholar7. FISKESUBARROW CHY: The colorimetric determination of phosphorus. J. Biol. Chem. 66: 375, 1925. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Framingham, MassachusettsFrom the Heart Disease Epidemiology Study, Framingham, Mass., and the National Heart Institute, National Institutes of Health, U. S. Public Health Service, Bethesda, Md.Requests for reprints should be addressed to William B. Kannel, M.D., Heart Disease Epidemiology Study, Dept. of Health, Education, and Welfare, 25 Evergreen St., Framingham, Mass. 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KANNEL, M.D., WILLIAM P. CASTELLI, M.D., TAVIA GORDON, PATRICIA M. MCNAMARAClinical aspects of lipid metabolismDiabetes e hiperlipoproteinemia en la enfermedad aterosclerosa del coraz�nCoronary Disease and Carbohydrate and Fat AbnormalitiesAntihyperlipidemic AgentsDetection of individual susceptibility toward coronary diseasePrevention of myocardial infarctionLipoprotein PhenotypingNutrition and Cardiovascular DiseaseA study of the primary prevention of coronary heart disease.Hyperlipidemia in Atherosclerosis: Dietary and Drug TreatmentIntermittent ClaudicationCholesterol, Atherosclerosis, Ischemic Heart Disease, and StrokeSEYMOUR DAYTON, M.D., JOHN M. CHAPMAN, M.D., MORTON LEE PEARCE, M.D., GEORGE J. POPJÁK, M.D.Results of the Epidemologic Investigation of Ischaemic Heart Disease: Illustrated by the Framingham StudyRISKS OF ISCHÆMIC HEART-DISEASE IN FAMILIAL HYPERLIPOPROTEINÆMIC STATESSTERILITY OF EYE-DROPSCARDIAC TRANSPLANTATION, CORONARY ATHEROMA, AND ISCHÆMIC HEART-DISEASEFamilial Type IV HyperlipoproteinemiaFASTING SERUM TRIGLYCERIDE, CHOLESTEROL, AND LIPOPROTEIN LEVELS DURING ORAL-CONTRACEPTIVE THERAPYMetabolic Effects of Oral ContraceptivesA Shifting CurveLipid and carbohydrate abnormalities in patients with angiographically documented coronary artery diseaseMetabolic basis of human atherosclerosisBlood Pressure and Risk of Coronary Heart Disease: The Framingham StudyEstrogens in the Menopause and PostmenopauseMYOCARDIAL INFARCTION IN EARLY AGEFasting Serum Triglyceride and Cholesterol Levels During Oral Contraceptive TherapyHypolipidemic AgentsCoronary heart disease in HawaiiInterrelationships of Hyperinsulinism and Hypertriglyceridemia in Young Patients with Coronary Heart DiseasePROPHYLAXIS OF CORONARY HEART DISEASE, STROKE, AND PERIPHERAL ATHEROSCLEROSISPrevention of heart failureTissue changes in experimental chronic endogenous hyperlipemiaMETABOLIC ABNORMALITIES IN PREMATURE CORONARY DISEASE: EFFECTS OF THERAPYCoronary Heart Disease: Screening by Familial AggregationTHE PREVENTION OF CORONARY HEART DISEASEMyxedema and Coronary Artery Disease—A Comparative Autopsy StudyALFRED D. STEINBERG, M.D.Current Metabolic-Genetic Interrelationship in Human Atherosclerosis With Therapeutic ConsiderationsPETER T. KUO, M.D., F.A.C.P.REFERENCESEFFECT OF A SINGLE DOSE OF NICOTINIC ACID ON PLASMA LIPIDS IN PATIENTS WITH HYPERLIPOPROTEINEMIADiagnostic value of serum lipids and frequency of lipoprotein patterns in myocardial infarctionBlood Lipids in Man—A Brief ReviewMyocardial Infarction Among Southwestern American IndiansMAURICE L. SIEVERS, M.D., F.A.C.P.The pathogenesis of atherosclerotic complications in manPREVENTION OF CORONARY HEART DISEASEDietary Fats, Carbohydrates and Atherosclerotic Vascular DiseaseSerum Insulin, Carbohydrate, and Lipid Abnormalities in Patients with Premature Coronary Heart DiseaseMANUEL TZAGOURNIS, M.D., JOHN F. SEIDENSTICKER, M.D., GEORGE J. HAMWI, M.D., F.A.C.P.The influence of dietary regimens on serum fat in atherosclerotic subjectsCoronary angiography in the clinical analysis of suspected coronary diseaseSerum low-density lipoprotein levels in a New Zealand population samplePrimary prevention of coronary heart disease by dietA clinical evaluation of coronary arteriographyDIETARY FAT AND CORONARY HEART DISEASE: A REVIEWSerum Lipids, Nutrition and Atherosclerotic Complications in ManThe prevention of coronary heart diseaseCardiovascular Disease, Diabetes Mellitus, and Anthropometric Evaluation of Polynesian Males on the Island of Niihau-1963Presymptomatic Diagnosis of Ischæmic Heart DiseaseSOME EFFECTS OF ORAL CONTRACEPTIVES ON SERUM-LIPID AND LIPOPROTEIN LEVELSCoronary Angiographic Findings in Correlation with Age, Body Weight, Blood Pressure, Serum Lipids, and Smoking HabitsThe development of coronary heart disease in relation to sequential biennial measures of cholesterol in the framingham studyA Study of Coronary Heart Disease in Young MenControl of dietary fat in relation to diabetic complications in childrenAn assessment of the utility of the resting apex cardiogram in the epidemiology of cardiovascular diseaseTHE PRECURSORS OF HYPERTENSION AND CORONARY ARTERY DISEASE: INSIGHTS FROM STUDIES OF BIOLOGICAL VARIATIONBIBLIOGRAPHYThe Physician's Incompleat Guide to AtherosclerosisIRVINE H. PAGE, M.D., F.A.C.P., JEROME G. GREEN, M.D., ABEL LAZZARINI ROBERTSON, M.D., PH.D.Risikofaktoren beim HerzinfarktSymposium: Advances in Detection of Coronary Artery DiseaseCoronary Thrombosis Its Mechanism and Possible Prevention by Linolenic AcidP. A. OWREN, M.D. 1 November 1964Volume 61, Issue 5_Part_1Page: 888-899KeywordsCholesterolCongenital heart diseaseCoronary heart diseaseEpidemiologyHypertensionLongitudinal studiesMedical risk factorsMedical servicesOintmentsPrevention, policy, and public health Issue Published: 1 November 1964 PDF DownloadLoading ...
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