Robust and Efficient Mediation Analysis Via Huber Loss

Mediation analysis is one of the most popularly used methods in social sciences and related areas. To estimate the indirect effect, the least-squares regression is routinely applied, which is also the most efficient when the errors are normally distributed. In practice, however, real data sets are often non-normally distributed, either heavy-tailed or skewed, so that the least-squares estimators may behave very badly. To overcome this problem, we propose a robust M-estimation for the indirect effect via a general loss function, with a main focus on the Huber loss which is more slowly varying at large values than the squared loss. We further propose a data-driven procedure to select the optimal tuning constant by minimizing the asymptotic variance of the Huber estimator, which is more robust than the least-squares estimator facing outliers and non-normal data, and more efficient than the least-absolute-deviation estimator. Simulation studies compare the finite sample performance of the Huber loss with the existing competitors in terms of the mean square error, the type I error rate, and the statistical power. Finally, the usefulness of the proposed method is also illustrated using two real data examples.