Role of Calcium Ions in Regulation of Mammalian Intramitochondrial Metabolism.

articleRole of calcium ions in regulation of mammalian intramitochondrial metabolismJ. G. McCormack, A. P. Halestrap, and R. M. DentonJ. G. McCormackDepartment of Biochemistry, University of Leeds, United Kingdom., A. P. HalestrapDepartment of Biochemistry, University of Leeds, United Kingdom., and R. M. DentonDepartment of Biochemistry, University of Leeds, United Kingdom.Published Online:01 Apr 1990https://doi.org/10.1152/physrev.1990.70.2.391MoreSectionsPDF (9 MB)Download PDF ToolsExport citationAdd to favoritesGet permissionsTrack citations ShareShare onFacebookTwitterLinkedInWeChat Previous Back to Top Next Download PDF FiguresReferencesRelatedInformation Cited ByDeterminants, maintenance, and function of organellar pHSpencer A. Freeman, Sergio Grinstein, and John Orlowski14 October 2022 | Physiological Reviews, Vol. 103, No. 1Energy metabolism design of the striated muscle cellBrian Glancy and Robert S. 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Graham1 October 1996 | Journal of Applied Physiology, Vol. 81, No. 4Intracellular free Na+ concentration increases in cultured retinal cells under oxidative stress conditionsNeuroscience Research, Vol. 25, No. 4Increase of voltage-sensitive calcium channels and calcium accumulation in skeletal muscles of streptozocin-induced diabetic ratsMetabolism, Vol. 44, No. 11Effect of Aminophylline on High-energy Phosphate Metabolism and Fatigue in the DiaphragmAnesthesiology, Vol. 83, No. 3Decoding of cytosolic calcium oscillations in the mitochondriaCell, Vol. 82, No. 3Bioenergetics in the pathogenesis, progression and treatment of cardiovascular disordersMedical Hypotheses, Vol. 44, No. 5[24] Mitochondrial cation transport systemsCaffeine and Ca2+ stimulate mitochondrial oxidative phosphorylation in saponin-skinned human skeletal muscle fibers due to activation of actomyosin ATPaseBiochimica et Biophysica Acta (BBA) - Bioenergetics, Vol. 1188, No. 3The effect of calcium on mitochondrial contact sites: a study on isolated rat heartsBiochimica et Biophysica Acta (BBA) - Molecular Cell Research, Vol. 1224, No. 3Central neural mechanisms mediating excitation of sympathetic neurons by hypoxiaProgress in Neurobiology, Vol. 44, No. 2Regulation of fatty acid oxidation in the mammalian heart in health and diseaseBiochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, Vol. 1213, No. 3Intracellular Ca2+ transients in isolated perfused rat heart: measurement using the fluorescent indicator Fura-2AMCell Calcium, Vol. 16, No. 2Characterization of Ca2+ transport in Euglena gracilis mitochondriaBiochimica et Biophysica Acta (BBA) - Bioenergetics, Vol. 1186, No. 1-2Ions and energy in mammalian brainProgress in Neurobiology, Vol. 43, No. 1Relationship between intracellular calcium and oxygen consumption: Effects of perfusion pressure, extracellular calcium, dobutamine, and nifedipineAmerican Heart Journal, Vol. 127, No. 2Glutamate impairs neuronal calcium extrusion while reducing sodium gradientNeuron, Vol. 12, No. 2Caffeine-induced calcium release from internal stores in cultured rat sensory neuronsNeuroscience, Vol. 57, No. 3Modulation of intramitochondrial free Ca2+ concentration by antagonists of Na+-Ca2+ exchangeTrends in Pharmacological Sciences, Vol. 14, No. 11The mechanisms by which mild respiratory chain inhibitors inhibit hepatic gluconeogenesisBiochimica et Biophysica Acta (BBA) - Bioenergetics, Vol. 1142, No. 1-2Regulation of fatty acid oxidation in mammalian liverBiochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, Vol. 1167, No. 3Regulation of mitochondrial glycerol-phosphate dehydrogenase by Ca2+ within electropermeabilized insulin-secreting cells (INS-1)Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, Vol. 1175, No. 1Myocardial energetics during ventricular fibrillation investigated by magnetization transfer nuclear magnetic resonance spectroscopy.Circulation Research, Vol. 71, No. 5Relation of mitochondrial and cytosolic free calcium to cardiac myocyte recovery after exposure to anoxia.Circulation Research, Vol. 71, No. 3Demonstration of ryanodine-induced metabolic effects in rat liverBiochemical Pharmacology, Vol. 44, No. 3Hexose metabolism in pancreatic isletsBiochemical Medicine and Metabolic Biology, Vol. 48, No. 1Fasting induced alterations in mitochondrial palmitoyl-coa metabolism may inhibit adipocyte pyruvate dehydrogenase activityInternational Journal of Biochemistry, Vol. 24, No. 5Oxygen and acid chemoreception in the carotid body chemoreceptorsTrends in Neurosciences, Vol. 15, No. 4The effect of alkanols on Ca2+ transport in brain mitochondriaCell Calcium, Vol. 13, No. 1Selective stimulation of in situ intermediary metabolism by free calcium in permeabilized rat adipocytesBiochimica et Biophysica Acta (BBA) - Molecular Cell Research, Vol. 1133, No. 1Aortic and carotid body chemoreception in prolonged hyperoxia in the catRespiration Physiology, Vol. 86, No. 2Regulation of renal ammoniagenesis in metabolic acidosisKidney International, Vol. 40, No. 5Effects of calcium on hepatocyte iron uptake from transferrin, iron-pyrophosphate and iron-ascorbateBiochimica et Biophysica Acta (BBA) - Molecular Cell Research, Vol. 1095, No. 1Control of oxidative phosphorylation in mitochondria, cells and tissuesInternational Journal of Biochemistry, Vol. 23, No. 11Alcohol stimulates Na+/Ca2+ exchange in brain mitochondriaLife Sciences, Vol. 48, No. 10An hypothesis: Phosphorylation fields as the source of positional information and cell differentiation—(cAMP, ATP) as the universal morphogenetic turing coupleProgress in Biophysics and Molecular Biology, Vol. 56, No. 2Ca2+ extrusion across plasma membrane and Ca2+ uptake by intracellular storesPharmacology & Therapeutics, Vol. 50, No. 2Mechanisms involved in the hormonal regulation of mitochondrial function through changes in the matrix volumeBiochimica et Biophysica Acta (BBA) - Bioenergetics, Vol. 1018, No. 2-3The role of mitochondrial Ca2+ transport and matrix Ca2+ in signal transduction in mammalian tissuesBiochimica et Biophysica Acta (BBA) - Bioenergetics, Vol. 1018, No. 2-3Ca2+ binding to citrate cycle dehydrogenasesInternational Journal of Biochemistry, Vol. 22, No. 10 More from this issue > Volume 70Issue 2April 1990Pages 391-425 Copyright & PermissionsCopyright © 1990 the American Physiological Societyhttps://doi.org/10.1152/physrev.1990.70.2.391PubMed2157230History Published online 1 April 1990 Published in print 1 April 1990 Metrics