The aim of the research. Analysis of the frequency of genotype polymorphism rs231775 gene STLA4 in patients with asthma, residents of Krasnoyarsk, as well as assessing the relationship of the studied polymorphisms and asthma. Materials and methods. Genomic DNA was isolated from 10 ml of venous blood by phenol-chloroform extraction. DNA testing was conducted using the polymerase chain reaction in real time. A group of patients with bronchial asthma -100 persons, the control group 338 persons. Results. It was studied the frequency of polymorphism rs231775 gene CTLA4 separately in patients with allergic and nonallergic bronchial asthma (BA). A comparative analysis revealed that in patients with allergic asthma the frequency of genotype G / G was 1.7 times higher as compared with the control group and was amounted in allergic asthma patients 36.4% in the control group -21.9% (p = 0.031). Frequency of genotype G / G and A / A + A / G polymorphism rs231775 CTLA4 gene in AD patients was 36.4% and 63.6%, while in the control group 21.9% and 78.1% respectively. Conclusion. In the study of frequency polymorphism rs231775 gene CTLA4 was revealed the increasing the frequency of genotype G / G in the group of patients with allergic asthma. Considering these results, we can conclude that the genotype G / G (OR = 2.036; 95% CI -1,16-3,58, r1-3 = 0.012) determine increased risk of allergic asthma.
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