Ruthenium(Iii) Complexes of Macrocyclic Tertiary Amines Mediated No Release from S-Nitrosothiols under in Vitro and in Vivo Conditions

There′s just NO SNAP! RuIII complexes of macrocyclic tertiary amines, especially trans-[Ru(14-TMC)Cl2]Cl (1), could mediate nitric oxide (NO) release from S-nitrosothiols in the presence of biological reductants. Interestingly, complex 1 was found to enhance rat aorta relaxation in the presence of S-nitroso-N-acetylpenicillamine (SNAP) under in vivo conditions. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.