Flexible tactile sensors have attracted extensive attention in fields such as wearable electronics, human–machine interaction, intelligent prosthetics, and robotics. However, their practical applications remain limited by several challenges, including signal interference, trade-offs among sensitivity, sensing range, and mechanical durability, as well as insufficient fatigue resistance under long-term cyclic deformation. Human skin, with its multiscale hierarchical structures, gradient mechanical properties, and spatially distributed mechanoreceptors, provides an important bioinspired model for addressing these challenges. This review summarizes recent advances in skin-inspired flexible tactile sensors, with a focus on the translation of biological skin structures into engineering designs. First, the relationships between biological skin structures and artificial sensor architectures are discussed, emphasizing the roles of skin microstructures, hierarchical architectures, and mechanoreceptor distributions in regulating deformation behaviors and sensing responses. Subsequently, representative bioinspired structural designs and key engineering regulation strategies are summarized, and their contributions to enhanced tactile sensing performance are discussed. In addition, skin-inspired strategies for multimodal perception and self-healing capabilities are reviewed. Finally, applications of skin-inspired tactile sensors in health monitoring, intelligent prosthetics, human–machine interaction, and robotic systems are summarized, followed by an outlook of future development directions.
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