Some Sources of Error in Measuring Regional Blood Flow with Radioactive Microspheres.

ArticleSome sources of error in measuring regional blood flow with radioactive microspheres.G D Buckberg, J C Luck, D B Payne, J I Hoffman, J P Archie, and D E FixlerG D Buckberg, J C Luck, D B Payne, J I Hoffman, J P Archie, and D E FixlerPublished Online:01 Oct 1971https://doi.org/10.1152/jappl.1971.31.4.598MoreSectionsPDF (2 MB)Download PDF ToolsExport citationAdd to favoritesGet permissionsTrack citations ShareShare onFacebookTwitterLinkedInEmailWeChat Previous Back to Top Next Download PDF FiguresReferencesRelatedInformationCited ByBone loss after severe spinal cord injury coincides with reduced bone formation and precedes bone blood flow deficitsJoshua F. Yarrow, Russell D. Wnek, Christine F. Conover, Michael C. Reynolds, Kinley H. Buckley, Jayachandra R. Kura, Tommy W. Sutor, Dana M. Otzel, Alex J. Mattingly, Summer Croft, J. Ignacio Aguirre, Stephen E. Borst, Darren T. Beck, and Danielle J. 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M. Parisi, and S. W. Walsh1 July 1989 | American Journal of Physiology-Endocrinology and Metabolism, Vol. 257, No. 1Effects of nitroglycerin on regional O2 supply and O2 consumption in reperfused dog myocardiumEuropean Journal of Pharmacology, Vol. 166, No. 2Does tissue-type plasminogen activator have direct beneficial effects on the myocardium independent of its ability to lyse intracoronary thrombi?Circulation, Vol. 79, No. 5Blood flow to the respiratory muscles during hypercapnic hyperpnoea in the newborn lambRespiration Physiology, Vol. 76, No. 1Effects of hypercapnia on cerebral blood flow following prophylactic and delayed experimental superficial temporal artery-middle cerebral artery bypassSurgical Neurology, Vol. 31, No. 3Nicardipine after spinal cord compression in the lambSurgical Neurology, Vol. 31, No. 2Myocardial contractility, blood flow, and oxygen consumption in healthy dogs during anesthesia with isoflurane or enfluraneJournal of Cardiothoracic Anesthesia, Vol. 3, No. 1Effects of Traumatic Brain Injury on Regional Cerebral Blood Flow in Rats as Measured with Radiolabeled Microspheres29 June 2016 | Journal of Cerebral Blood Flow & Metabolism, Vol. 9, No. 1Relationship between beta-adrenoceptors and coronary blood flow heterogeneityLife Sciences, Vol. 44, No. 17Ocular blood flow in dogs using radiolabelled microspheresInternational Journal of Radiation Applications and Instrumentation. Part B. Nuclear Medicine and Biology, Vol. 16, No. 1Regional hemodynamics and oxygen supply during isovolemic hemodilution in the absence and presence of high-grade β-adrenergic blockadeJournal of Cardiothoracic Anesthesia, Vol. 2, No. 6Response of the cerebral circulation to profound hypocarbia in neonatal lambs.Stroke, Vol. 19, No. 11Postsystolic shortening of acutely ischemic canine myocardium predicts early and late recovery of function after coronary artery reperfusion.Circulation, Vol. 78, No. 4Considerations in use of microspheres for myocardial blood-flow measurements in long-term experiments on ratsJournal of Pharmacological Methods, Vol. 20, No. 2Evaluation of nonradioactive, colored microspheres for measurement of regional myocardial blood flow in dogs.Circulation, Vol. 78, No. 2Blood flow, O2 extraction and O2 consumption along the rat small intestineMicrovascular Research, Vol. 35, No. 3Improved distribution of regional oxygenation in denervated ischemic dog myocardium.Circulation Research, Vol. 62, No. 5A model for regional blood flow measurements during cardiopulmonary resuscitation in a swine modelResuscitation, Vol. 16, No. 2The effect of arterial pressure alterations during halothane anesthesia on residual flow and infarct size With transient regional ischemia of the dogJournal of Cardiothoracic Anesthesia, Vol. 2, No. 2Myocardial oxygen consumption, oxygen supply/demand heterogeneity, and microvascular patency in regionally stunned myocardium.Circulation, Vol. 77, No. 4Role of α-adrenoceptors in the control of the cerebral blood flow response to hypoxiaEuropean Journal of Pharmacology, Vol. 148, No. 1Computerized stripping method for multiple nuclide microsphere studiesComputers and Biomedical Research, Vol. 21, No. 1Regulation of cerebral blood flow after asphyxia in neonatal lambs.Stroke, Vol. 19, No. 2Biphasic pulp blood-flow response to substance P in the dog as measured with a radiolabelled, microsphere injection methodArchives of Oral Biology, Vol. 33, No. 5The Effects of Traumatic Brain Injury on Regional Cerebral Blood Flow in RatsJournal of Neurotrauma, Vol. 5, No. 4Canine biventricular performance during acute progressive pulmonary microembolization: Regional myocardial perfusion and fatty acid uptakeJournal of Critical Care, Vol. 2, No. 4Measurement of myocardial blood flow by ultrafast computed tomography.Circulation, Vol. 76, No. 6Blood flow and distribution in the canine pancreasJournal of Surgical Research, Vol. 43, No. 3Brain circulation during sleep and its relation to extracerebral hemodynamicsBrain Research, Vol. 415, No. 1Effects of chronic exercise on the coronary circulation in conscious rats with renovascular hypertension.Hypertension, Vol. 10, No. 1Comparison of thermal clearance measurement of regional cerebral blood flow with radiolabelled microspheres.Stroke, Vol. 18, No. 3Regional distribution of brain blood flow during maximal exertion in splenectomized poniesRespiration Physiology, Vol. 68, No. 1Measurement of coronary blood flow: A critical reviewJournal of Surgical Research, Vol. 42, No. 3Origins and regional distribution of blood flow to the respiratory muscles in conscious sheepRespiration Physiology, Vol. 67, No. 3Blood flow measurement in the canine pancreasJournal of Surgical Research, Vol. 42, No. 1Cochlear blood flow in the rat. A methodological evaluation of the microsphere methodHearing Research, Vol. 27, No. 1Time-dependent effects of prolonged hypercapnia on cerebrovascular parameters in dogs: acid-base chemistry.Stroke, Vol. 18, No. 1Blood flow to transplanted fetal rat intestineJournal of Surgical Research, Vol. 41, No. 6The comparative effects of epinephrine versus phenylephrine on regional cerebral blood flow during carciopulmonary resuscitationResuscitation, Vol. 14, No. 3Failure of nitroglycerin introduced after prolonged myocardial ischemia to improve collateral blood flow and function in tranquilized dogsAmerican Heart Journal, Vol. 112, No. 3Regional brain blood flow and O2 delivery during severe exertion in the ponyRespiration Physiology, Vol. 64, No. 3Blood flow and functional responses correlate in the ovine neural lobeBrain Research, Vol. 373, No. 1-2The Influence of 5-Hydroxytryptamine (Serotonin) on Blood Flow in the Dog Pulp9 November 2016 | Journal of Dental Research, Vol. 65, No. 5Regional myocardial and organ blood flow after myocardial infarction: application of the microsphere principle in man.Circulation, Vol. 73, No. 3Exercise-induced regional dysfunction with subcritical coronary stenosis.Circulation, Vol. 73, No. 3Radioactively labelled silica beads for the determination of regional blood flow in ratsInternational Journal of Radiation Applications and Instrumentation. Part A. Applied Radiation and Isotopes, Vol. 37, No. 5Transmural coronary vasodilator reserve and flow distribution in unanesthetized calves sojourning at 3500 mJournal of Surgical Research, Vol. 39, No. 6Positron emission tomography of the heartProgress in Cardiovascular Diseases, Vol. 28, No. 3Right ventricular coronary flow in arterial hypertensionAmerican Heart Journal, Vol. 110, No. 4The effect of cardiopulmonary bypass on cerebral blood flowBrain Research, Vol. 345, No. 1Measurement of cerebral blood flow during xenon inhalation as measured by the microspheres method.Stroke, Vol. 16, No. 5Blood flow distribution during hypocapnic hypoxia in pekin ducks and bar-headed geeseRespiration Physiology, Vol. 61, No. 1Regional Flow-Metabolism Couple following Middle Cerebral Artery Occlusion in Cats29 June 2016 | Journal of Cerebral Blood Flow & Metabolism, Vol. 5, No. 2Hemodynamic response to normovolemic polycythemia at rest and during exercise in dogs.Circulation Research, Vol. 56, No. 6Improvement in regional myocardial O2 supply and O2 consumption by nitroglycerin during ischemiaEuropean Journal of Pharmacology, Vol. 112, No. 1Two hemodynamic problems commonly associated with the microsphere technique for measuring regional blood flow in ratsJournal of Pharmacological Methods, Vol. 13, No. 2Measurement of Tendon Blood Flow in Rabbits by Microsphere Uptake and 133 Xe Washout17 November 2016 | Journal of Hand Surgery, Vol. 10, No. 1Measurement of blood flow in the oral mucosa and skin of the rhesus monkey using radiolabelled microspheresArchives of Oral Biology, Vol. 30