Source Reconstructions by Spatial Deviation Scans

Reconstructions of generators of biomagnetic and bioelectric activity are nowadays dominated by single or multiple equivalent current dipole models. These methods suffer from the dependence of their results from the Start values of the nonlinear minimization algorithm that optimizes the dipole positions in order to achieve a minimum of the deviation Δ between the measured data M and the forward calculated field distribution L j: Δ2 = ∥ M − L j ∥2. The lead field matrix L depends on the sensor geometry, the dipole positions, and the volume conductor model. The optimum dipole components j that minimize Δ2 can be calculated by j = (L T L)−1 L T M.