Spatial Transcriptomics in HCC

Rama Shankar, Mengyao Tan,Yueqi Zhang, Ben Green, Joseph Zagorski, Austin Goodyke,Shreya Paithankar,Marie Adams,Galen Hostetter,Rebecca A. Siwicki, Sydney Hein,Doris Yang, Le‐Ting Zhou,Qing‐Sheng Mi,T. Tara Ghaziani,Renumathy Dhanasekaran,Dave Chesla, Xin Chen, Haifeng Xiao,Samuel So,Mei-Sze Chua,Bin Chen

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Zenodo (CERN European Organization for Nuclear Research)（2023）

Michigan State University

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The morbidity of Hepatocellular carcinoma (HCC) is highest in individuals with chronic liver diseases (CLD). However, the effects of cell composition on the progression of CLDs to HCC remain elusive. To gain a better understanding of the spatial distribution of cells and their interactions, we created spatial transcriptome data from two HCC and their normal adjacent FFPE tissues using the 10x visium platform. We processed the data using cellRanger and mapped it to the Human Hg38 reference genome with GRCh38.p3 annotation. All data generated by cellRanger is provided here

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