The system reliability analysis of complex engineering structures remains a challenge in the field of reliability. In this work, a high-order moment method using generalized factorized dimensional reduction method (GF-DRM) and iterative maximum entropy method (IMEM) is proposed for structural system reliability assessment. Firstly, the performance functions are described uniformly by equivalent description methods for various system reliability problems. Secondly, a novel point estimation method (PEM) based on GF-DRM is proposed for the high-order moments estimation of the equivalent performance function. Thirdly, the system failure probability of the structures is accurately determined by using the IMEM, which can automatically determine the order of moments. Finally, four examples, including numerical and engineering cases, are investigated to demonstrate the accuracy and efficiency of the proposed method, in which results obtained from the proposed method are compared with some other existing moment methods and Monte Carlo simulation (MCS) method. The results of the examples show the proposed method has fairly high accuracy and efficiency for structural high-order moments estimation and system reliability analysis.
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