Structure and Function of the Brain-Serotonin System

articleStructure and function of the brain serotonin systemB. L. Jacobs, and E. C. AzmitiaB. L. Jacobs1Department of Psychology, Princeton University, New Jersey., and E. C. Azmitia1Department of Psychology, Princeton University, New Jersey.Published Online:01 Jan 1992https://doi.org/10.1152/physrev.1992.72.1.165MoreSectionsPDF (19 MB)Download PDF ToolsExport citationAdd to favoritesGet permissionsTrack citations ShareShare onFacebookTwitterLinkedInEmail Previous Back to Top Next FiguresReferencesRelatedInformationCited ByPrinciples of odor coding in vertebrates and artificial chemosensory systemsIvan Manzini, Detlev Schild, and Corrado Di Natale27 October 2021 | Physiological Reviews, Vol. 102, No. 1Neuronal Circuits in Barrel Cortex for Whisker Sensory PerceptionJochen F. Staiger and Carl C. H. Petersen10 December 2020 | Physiological Reviews, Vol. 101, No. 1Serotonergic modulation across sensory modalitiesTyler R. Sizemore, Laura M. Hurley, and Andrew M. 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Puche, Matt Wachowiak, and Michael T. Shipley11 March 2016 | Journal of Neurophysiology, Vol. 115, No. 3Neural Basis of Brain Dysfunction Produced by Early Sleep Problems29 January 2016 | Brain Sciences, Vol. 6, No. 1Cocaine and Neuromolecular Imaging of Neurotransmitters in the BrainRecreational Use of Ecstasy (MDMA) and Hippocampal MemoryHippocampal NeurogenesisEffects of LSD on grooming behavior in serotonin transporter heterozygous (Sert) miceBehavioural Brain Research, Vol. 296Circadian rhythms of clock gene expression in the cerebellum of serotonin-deficient Pet-1 knockout miceBrain Research, Vol. 1630Neurotransmitter Systems in a Mild Blast Traumatic Brain Injury Model: Catecholamines and SerotoninJournal of Neurotrauma, Vol. 32, No. 16TALOS: A Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial to Test the Effects of Citalopram in Patients with Acute Stroke8 April 2015 | International Journal of Stroke, Vol. 10, No. 6Functional Selectivity and Antidepressant Activity of Serotonin 1A Receptor Ligands7 August 2015 | International Journal of Molecular Sciences, Vol. 16, No. 8Functional Interplay between Dopaminergic and Serotonergic Neuronal Systems during Development and Adulthood18 March 2015 | ACS Chemical Neuroscience, Vol. 6, No. 75-HT 1A Receptor-Mediated Autoinhibition and the Control of Serotonergic Cell Firing26 May 2015 | ACS Chemical Neuroscience, Vol. 6, No. 7Serotonergic Regulation of Prefrontal Cortical Circuitries Involved in Cognitive Processing: A Review of Individual 5-HT Receptor Mechanisms and Concerted Effects of 5-HT Receptors Exemplified by the Multimodal Antidepressant Vortioxetine16 March 2015 | ACS Chemical Neuroscience, Vol. 6, No. 7Robust presynaptic serotonin 5-HT1B receptor inhibition of the striatonigral output and its sensitization by chronic fluoxetine treatmentShengyuan Ding, Li Li, and Fu-Ming Zhou26 May 2015 | Journal of Neurophysiology, Vol. 113, No. 9Activity in descending dopaminergic neurons represents but is not required for leg movements in the fruit fly Drosophila5 March 2015 | Physiological Reports, Vol. 3, No. 3L-Dopa and Brain Serotonin System Dysfunction5 March 2015 | Toxics, Vol. 3, No. 1Serotonergic neurons signal reward and punishment on multiple timescales25 February 2015 | eLife, Vol. 4Nicotine increases GABAergic input on rat dorsal raphe serotonergic neurons through alpha7 nicotinic acetylcholine receptorF. Hernández-Vázquez, K. Chavarría, J. Garduño, S. Hernández-López, and S. P. Mihailescu15 December 2014 | Journal of Neurophysiology, Vol. 112, No. 12Caffeine's Attenuation of Cocaine-Induced Dopamine Release by Inhibition of AdenosineJournal of Caffeine Research, Vol. 4, No. 2Activation of group I metabotropic glutamate receptors enhances persistent sodium current and rhythmic bursting in main olfactory bulb external tufted cellsHong-Wei Dong, and Matthew Ennis1 February 2014 | Journal of Neurophysiology, Vol. 111, No. 3Synthesis, transport, and metabolism of serotonin formed from exogenously applied 5-HTP after spinal cord injury in ratsYaqing Li, Lisa Li, Marilee J. Stephens, Dwight Zenner, Katherine C. Murray, Ian R. Winship, Romana Vavrek, Glen B. Baker, Karim Fouad, and David J. Bennett1 January 2014 | Journal of Neurophysiology, Vol. 111, No. 1Medullary serotonin neurons are CO2 sensitive in situKimberly E. Iceman, George B. Richerson, and Michael B. Harris1 December 2013 | Journal of Neurophysiology, Vol. 110, No. 11Neuromolecular Imaging Shows Temporal Synchrony Patterns between Serotonin and Movement within Neuronal Motor Circuits in the Brain21 June 2013 | Brain Sciences, Vol. 3, No. 4A Subpopulation of Serotonergic Neurons That Do Not Express the 5-HT1A Autoreceptor20 November 2012 | ACS Chemical Neuroscience, Vol. 4, No. 1Midbrain Raphe Stimulation Improves Behavioral and Anatomical Recovery from Fluid-Percussion Brain InjuryJournal of Neurotrauma, Vol. 30, No. 2Control of Sleep and WakefulnessRitchie E. Brown, Radhika Basheer, James T. McKenna, Robert E. Strecker, and Robert W. McCarley1 July 2012 | Physiological Reviews, Vol. 92, No. 3Neonatal Citalopram Treatment Inhibits the 5-HT Depleting Effects of MDMA Exposure in Rats2 November 2011 | ACS Chemical Neuroscience, Vol. 3, No. 1Serotonin modulates the population activity profile of olfactory bulb external tufted cellsShaolin Liu, Jason L. Aungst, Adam C. Puche, and Michael T. Shipley1 January 2012 | Journal of Neurophysiology, Vol. 107, No. 1Transient Firing of Dorsal Raphe Neurons Encodes Diverse and Specific Sensory, Motor, and Reward EventsSachin P. Ranade, and Zachary F. Mainen1 November 2009 | Journal of Neurophysiology, Vol. 102, No. 5Investigation of serotonin-1A receptor function in the human psychopharmacology of MDMA17 July 2008 | Journal of Psychopharmacology, Vol. 23, No. 8Role of dorsal raphe nucleus 5-HT 1A and 5-HT 2 receptors in tonic immobility modulation in guinea pigsBrain Research, Vol. 1285Autoresuscitation responses to hypoxia-induced apnea are delayed in newborn 5-HT-deficient Pet-1 homozygous miceJeffery T. Erickson and Brian C. Sposato1 June 2009 | Journal of Applied Physiology, Vol. 106, No. 6Optimized Derivation and Functional Characterization of 5-HT Neurons from Human Embryonic Stem CellsStem Cells and Development, Vol. 18, No. 4A Review of the Pharmacokinetics, Pharmacodynamics and Efficacy of Zolmitriptan in the Acute Abortive Treatment of Migraine11 May 2009 | Clinical Medicine. Therapeutics, Vol. 1Effects of fluoxetine on the reproductive axis of female goldfish (Carassius auratus)Jan A. Mennigen, Christopher J. Martyniuk, Kate Crump, Huiling Xiong, E. Zhao, Jason Popesku, Hymie Anisman, Andrew R. Cossins, Xuhua Xia, and Vance L. Trudeau1 November 2008 | Physiological Genomics, Vol. 35, No. 3Laurate Biosensors Image Brain Neurotransmitters In Vivo: Can an Antihypertensive Medication Alter Psychostimulant Behavior?4 July 2008 | Sensors, Vol. 8, No. 7Persistent Inward Currents in Spinal Motoneurons and Their Influence on Human Motoneuron Firing Patterns7 November 2007 | The Neuroscientist, Vol. 14, No. 3Melanin-concentrating hormone (MCH) immunoreactivity in non-neuronal cells within the raphe nuclei and subventricular region of the brainstem of the catBrain Research, Vol. 1210Serotonin and Migraine: Biology and Clinical Implications26 June 2016 | Cephalalgia, Vol. 27, No. 11Neuroendocrine Mechanisms, Stress Coping Strategies, and Social Dominance: Comparative Lessons about Leadership Potential1 September 2016 | The ANNALS of the American Academy of Political and Social Science, Vol. 614, No. 1Challenge Tests of Monoaminergic Systems: Neurophysiological Aspects25 June 2016 | Clinical EEG and Neuroscience, Vol. 38, No. 2Tryptophan Depletion Increases Nausea, Headache and Photophobia in Migraine Sufferers26 June 2016 | Cephalalgia, Vol. 26, No. 10Rating of Olfactory Judgements in Migraine Patients26 June 2016 | Cephalalgia, Vol. 26, No. 9Central pathways of pulmonary and lower airway vagal afferentsLeszek Kubin, George F. Alheid, Edward J. Zuperku, and Donald R. McCrimmon1 August 2006 | Journal of Applied Physiology, Vol. 101, No. 2Inhibition of serotonergic medullary raphe obscurus neurons suppresses genioglossus and diaphragm activities in anesthetized but not conscious ratsSandeep Sood, Eric Raddatz, Xia Liu, Hattie Liu, and Richard L. Horner1 June 2006 | Journal of Applied Physiology, Vol. 100, No. 6Serotonergic Modulation of Inspiratory Hypoglossal Motoneurons in Decerebrate DogsIvo F. Brandes, Edward J. Zuperku, Astrid G. Stucke, Danica Jakovcevic, Francis A. Hopp, and Eckehard A. E. Stuth1 June 2006 | Journal of Neurophysiology, Vol. 95, No. 6Tryptophan-deficient diet increases the neurochemical and behavioral response to amphetamineBrain Research, Vol. 1094, No. 1“Fatigue” of medullary but not mesencephalic raphe serotonergic neurons during locomotion in catsBrain Research, Vol. 1072, No. 1Centrally administered adrenomedullin 2 activates hypothalamic oxytocin-secreting neurons, causing elevated plasma oxytocin level in ratsHirofumi Hashimoto, Susumu Hyodo, Makoto Kawasaki, Takashi Mera, Lei Chen, Atsushi Soya, Takeshi Saito, Hiroaki Fujihara, Takashi Higuchi, Yoshio Takei, and Yoichi Ueta1 November 2005 | American Journal of Physiology-Endocrinology and Metabolism, Vol. 289, No. 5Antagonism of corticotropin-releasing hormone alters serotonergic-induced changes in brain temperature, but not sleep, of ratsLuca Imeri, Susanna Bianchi, and Mark R. Opp1 October 2005 | American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, Vol. 289, No. 4Acute dopamine/norepinephrine reuptake inhibition increases brain and core temperature in ratsHiroshi Hasegawa, Romain Meeusen, Sophie Sarre, Marc Diltoer, Maria Francesca Piacentini, and Yvette Michotte1 October 2005 | Journal of Applied Physiology, Vol. 99, No. 4GABAergic Control of the Ascending Input From the Median Raphe Nucleus to the Limbic SystemShaomin Li, Viktor Varga, Attila Sik, and Bernat Kocsis1 October 2005 | Journal of Neurophysiology, Vol. 94, No. 4Does Serotonin Influence Aggression? Comparing Regional Activity before and during Social InteractionPhysiological and Biochemical Zoology, Vol. 78, No. 5Membrane cholesterol oxidation inhibits ligand binding function of hippocampal serotonin 1A receptorsBiochemical and Biophysical Research Communications, Vol. 331, No. 2Carotid body denervation alters ventilatory responses to ibotenic acid injections or focal acidosis in the medullary rapheM. R. Hodges, C. Opansky, B. Qian, S. Davis, J. M. Bonis, K. Krause, L. G. Pan, and H. V. Forster1 April 2005 | Journal of Applied Physiology, Vol. 98, No. 4Diurnal variation in serotonin immunoreactivity in the dorsal raphe nucleusBrain Research, Vol. 1034, No. 1-2Transient attenuation of CO2 sensitivity after neurotoxic lesions in the medullary raphe area of awake goatsM. R. Hodges, C. Opansky, B. Qian, S. Davis, J. Bonis, J. Bastasic, T. Leekley, L. G. Pan, and H. V. Forster1 December 2004 | Journal of Applied Physiology, Vol. 97, No. 6Serotonergic and Nonserotonergic Dorsal Raphe Neurons Are Pharmacologically and Electrophysiologically HeterogeneousSilvia Marinelli, Stephen A. Schnell, Stephen P. Hack, MacDonald J. Christie, Martin W. Wessendorf, and Christopher W. Vaughan1 December 2004 | Journal of Neurophysiology, Vol. 92, No. 65-HT1A Receptors, Gene Repression, and Depression: Guilt by Association29 June 2016 | The Neuroscientist, Vol. 10, No. 6Reciprocal connections between subdivisions of the dorsal raphe and the nuclear core of the locus coeruleus in the ratBrain Research, Vol. 1026, No. 1Cocaine-induced ???active immobility??? and its modulation by the serotonin1A receptorBehavioural Pharmacology, Vol. 15, No. 7Effect of Mg2+ on guanine nucleotide sensitivity of ligand binding to serotonin1A receptors from bovine hippocampusBiochemical and Biophysical Research Communications, Vol. 323, No. 2Changes of body temperature and extracellular serotonin level in the preoptic area and anterior hypothalamus after thermal or serotonergic pharmacological stimulation of freely moving ratsLife Sciences, Vol. 75, No. 22The intensity dependence of the auditory evoked N1 component as a predictor of reponse to Citalopram treatment in patients with major depressionNeuroscience Letters, Vol. 367, No. 3Effects of Norepinephrine Depletion in Rats During Cerebral Post-ischemic ReperfusionNeuroToxicology, Vol. 25, No. 5Theta Rhythm of the Hippocampus: Subcortical Control and Functional Significance18 May 2016 | Behavioral and Cognitive Neuroscience Reviews, Vol. 3, No. 3Sudden Infant Death Syndrome: Case-Control Frequency Differences at Genes Pertinent to Early Autonomic Nervous System Embryologic DevelopmentPediatric Research, Vol. 56, No. 3Inescapable shock activates serotonergic neurons in all raphe nuclei of ratBehavioural Brain Research, Vol. 153, No. 1Regional mRNA expression of a second tryptophan hydroxylase isoform in postmortem tissue samples of two human brainsEuropean Neuropsychopharmacology, Vol. 14, No. 4Serotonin neurons derived from rhesus monkey embryonic stem cells: similarities to CNS serotonin neuronsExperimental Neurology, Vol. 188, No. 2Nucleus accumbens serotonin1A receptors control cocaine-induced hyperactivity but not local serotonin increase: an in vivo microdialysis studyNeuropharmacology, Vol. 47, No. 2Interictal Lack of Habituation of Mismatch Negativity in Migraine26 June 2016 | Cephalalgia, Vol. 24, No. 8The sterol-binding antibiotic nystatin differentially modulates ligand binding of the bovine hippocampal serotonin 1A receptorBiochemical and Biophysical Research Communications, Vol. 320, No. 2Recent progress in 5-HT 7 receptors: potential treatment of central and peripheral nervous system diseases25 February 2005 | Expert Opinion on Therapeutic Patents, Vol. 14, No. 7Differential expression of 5HT-1A, ?1b adrenergic, CRF-R1, and CRF-R2 receptor mRNA in serotonergic, ?-aminobutyric acidergic, and catecholaminergic cells of the rat dorsal raphe nucleus1 January 2004 | The Journal of Comparative Neurology, Vol. 474, No. 3Serotonin innervation of the primate suprachiasmatic nucleusBrain Research, Vol. 1010, No. 1-2Ascl1/Mash1 is required for the development of central serotonergic neurons9 May 2004 | Nature Neuroscience, Vol. 7, No. 6Serotonergic neurons as carbon dioxide sensors that maintain ph homeostasisNature Reviews Neuroscience, Vol. 5, No. 6Cataplexy-Active Neurons in the HypothalamusNeuron, Vol. 42, No. 4Cholesterol modulates ligand binding and G-protein coupling to serotonin1A receptors from bovine hippocampusBiochimica et Biophysica Acta (BBA) - Biomembranes, Vol. 1663, No. 1-2Increased expression of 5-HT1B receptor in dorsal raphe nucleus decreases fear-potentiated startle in a stress dependent mannerBrain Research, Vol. 1007, No. 1-2Serotonin transporter in substance P (neurokinin 1) receptor knock-out miceEuropean Journal of Pharmacology, Vol. 492, No. 1Increased brain serotonin turnover correlates with the degree of shunting and hyperammonemia in rats following variable portal vein stenosisJournal of Hepatology, Vol. 40, No. 5Recent advances in understanding serotonin regulation of cardiovascular functionTrends in Molecular Medicine, Vol. 10, No. 5Differential development of 5-HT receptor and the serotonin transporter binding in the human infant medulla1 January 2004 | The Journal of Comparative Neurology, Vol. 472, No. 2Persistent respiratory changes following intermittent hypoxic stimulation in cats and human beingsRespiratory Physiology & Neurobiology, Vol. 140, No. 1Sensorimotor-related discharge of simultaneously recorded, single neurons in the dorsal raphe nucleus of the awake, unrestrained ratBrain Research, Vol. 1000, No. 1-2The Ets transcription factor Fev is specifically expressed in the human central serotonergic neuronsNeuroscience Letters, Vol. 357, No. 3Sub-chronic exposure to toluene at 40ppm alters the monoamine biosynthesis rate in discrete brain areasToxicology, Vol. 196, No. 1-2Temperature-dependent interaction of the bovine hippocampal serotonin 1A receptor with G-proteins9 July 2009 | Molecular Membrane Biology, Vol. 21, No. 2Median and Dorsal Raphe Neurons Are Not Electrophysiologically IdenticalSheryl G. Beck, Yu-Zhen Pan, Adaure C. Akanwa, and Lynn G. Kirby1 February 2004 | Journal of Neurophysiology, Vol. 91, No. 2Immobilization stress elevates tryptophan hydroxylase mRNA and protein in the rat raphe nucleiBiological Psychiatry, Vol. 55, No. 3Effect of the adenosine A2A receptor antagonist 8-(3-chlorostyryl)caffeine on l-DOPA biotransformation in rat striatumBrain Research, Vol. 998, No. 2Dense serotonergic innervation of principal nuclei of the superior olivary complex in mouseNeuroscience Letters, Vol. 356, No. 3A serotonergic (5-HT2) receptor mechanism in the laterodorsal tegmental nucleus participates in regulating the pattern of rapid-eye-movement sleep occurrence in the ratBrain Research, Vol. 996, No. 1Non-serotonergic dorsal and median raphe projection onto parvalbumin- and calbindin-containing neurons in hippocampus and septumNeuroscience, Vol. 124, No. 3Prostaglandin E2 in the medial preoptic area produces hyperalgesia and activates pain-modulating circuitry in the rostral ventromedial medullaNeuroscience, Vol. 128, No. 2Does leptin link sleep loss and breathing disturbances with major public diseases?8 July 2009 | Annals of Medicine, Vol. 36, No. 3The developmental role of serotonin: news from mouse molecular genetics1 December 2003 | Nature Reviews Neuroscience, Vol. 4, No. 12The Modulation by 5‐HT of Glutamatergic Inputs from the Raphe Pallidus to Rat Hypoglossal Motoneurones, in vitro1 December 2003 | The Journal of Physiology, Vol. 553, No. 3Disruption of the nonneuronal tph1 gene demonstrates the importance of peripheral serotonin in cardiac function3 November 2003 | Proceedings of the National Academy of Sciences, Vol. 100, No. 23Midbrain serotonergic neurons are central pH chemoreceptors28 September 2003 | Nature Neuroscience, Vol. 6, No. 11Targeting conditional gene modification into the serotonin neurons of the dorsal raphe nucleus by viral delivery of the Cre recombinaseMolecular and Cellular Neuroscience, Vol. 24, No. 1Lmx1b is essential for the development of serotonergic neurons3 August 2003 | Nature Neuroscience, Vol. 6, No. 9In vivo modulation of 5-hydroxytryptamine release in mouse prefrontal cortex by local 5-HT2A receptors: effect of antipsychotic drugsEuropean Journal of Neuroscience, Vol. 18, No. 5Interleukin-1beta enhances non-rapid eye movement sleep when microinjected into the dorsal raphe nucleus and inhibits serotonergic neurons in vitroEuropean Journal of Neuroscience, Vol. 18, No. 5Chronic social stress: effects on limbic brain structuresPhysiology & Behavior, Vol. 79, No. 3Organization of projections from the raphe nuclei to the vestibular nuclei in ratsNeuroscience, Vol. 120, No. 2Functional interactions between native Gs-coupled 5-HT receptors in HEK-293 cells and the heterologously expressed serotonin transporterCellular Signalling, Vol. 15, No. 85-HT1B receptor mRNA levels in dorsal raphe nucleus: inverse association with anxiety behavior in the elevated plus mazePharmacology Biochemistry and Behavior, Vol. 75, No. 4Characterization of reproductive steroid receptors and response to estrogen in a rat serotonergic cell lineJournal of Neuroscience Methods, Vol. 127, No. 1Projections from the raphe nuclei to the suprachiasmatic nucleus of the ratJournal of Chemical Neuroanatomy, Vol. 25, No. 4Sex steroid hormones and the neural control of breathingRespiratory Physiology & Neurobiology, Vol. 136, No. 2-3Effects of chronic paroxetine treatment on dialysate serotonin in 5-HT1B receptor knockout mice4 February 2004 | Journal of Neurochemistry, Vol. 86, No. 1Serotonin transport is modulated differently by tetanus toxin and growth factorsNeurochemistry International, Vol. 42, No. 7l-DOPA-derived extracellular dopamine in the striatum with dopaminergic denervation: role of serotonergic neurons in l-DOPA metabolismInternational Congress Series, Vol. 1251Operant learning and differential-reinforcement-of-low-rate 36-s responding in 5-HT1A and 5-HT1B receptor knockout miceBehavioural Brain Research, Vol. 141, No. 2Comparative effects of injecting 5,6-dihydroxytryptamine in the dorsal or medial raphe nuclei on rat pubertyBrain Research Bulletin, Vol. 60, No. 3The neuroanatomy of schizophrenia: circuitry and neurotransmitter systemsClinical Neuroscience Research, Vol. 3, No. 1-2GABAB receptor subunits, R1 and R2, in brainstem catecholamine and serotonin neuronsBrain Research, Vol. 970, No. 1-2Response of the Mouse Circadian System to Serotonin 1A/2/7 Agonists in vivo: Surprisingly Little29 June 2016 | Journal of Biological Rhythms, Vol. 18, No. 2Sudden infant death syndrome: Association with a promoter polymorphism of the serotonin transporter gene21 February 2003 | American Journal of Medical Genetics, Vol. 117A, No. 3Evidence for a role of the 5-HT2C receptor in central lipopolysaccharide-, interleukin-1β-, and leptin-induced anorexiaPharmacology Biochemistry and Behavior, Vol. 74, No. 4Control of 5-Hydroxytryptamine Release in the Dorsal Raphe Nucleus by the Noradrenergic System in Rat Brain. Role of α-Adrenoceptors19 July 2002 | Neuropsychopharmacology, Vol. 28, No. 35-HT2 Receptors Promote Plateau Potentials in Turtle Spinal Motoneurons by Facilitating an L-Type Calcium CurrentJean-François Perrier, and Jørn Hounsgaard1 February 2003 | Journal of Neurophysiology, Vol. 89, No. 2Evidence for disturbed cortical signal processing and altered serotonergic neurotransmission in generalized anxiety disorderBiological Psychiatry, Vol. 53, No. 4Glutamatergic afferent projections to the dorsal raphe nucleus of the ratBrain Research, Vol. 963, No. 1-2Cholecystokinin combined with serotonin in the hypothalamus limits accumbens dopamine release while increasing acetylcholine: a possible satiation mechanismBrain Research, Vol. 963, No. 1-2Superior colliculus stimulation enhances neocortical serotonin release and electrocorticographic activation in the urethane-anesthetized ratBrain Research, Vol. 964, No. 1Distinguishing characteristics of serotonin and non-serotonin-containing cells in the dorsal rap