Supplemental Figure 3 from Randomized Phase II Study Evaluating the Addition of Pembrolizumab to Radium-223 in Metastatic Castration-resistant Prostate Cancer

Swimmer’s plot of treatments received. Number of radium-223 and pembrolizumab doses received are listed to the left and right of the bars, respectively. The brackets “[” and “]” represent the planned break period from radium-223 dosing with “[” representing cycle 3 day 28 and “]” representing cycle 4 day 1 when the interval between these was greater than 28 days. Patients could resume radium treatment at radiographic progression by PCWG2 criteria (“△”) if there were no new visceral metastases, but two patients (bars 7 and 13 below) resumed without confirmed radiographic progression.