Supplemental Figures from An HK2 Antisense Oligonucleotide Induces Synthetic Lethality in HK1<sup>−</sup>HK2<sup>+</sup> Multiple Myeloma

This file contains supplemental figures: Supplemental Figure S1. HK2 ASOs selectively inhibit the proliferation of HK1-HK2+ MM cells. Supplemental Figure S2. The HK2-ASO1/DPI/PER combination causes synthetic lethality in HK1-HK2+ cells. Supplemental Figure 3. In vivo effects of HK2-ASO1, DPI, PER on MM OPM2 xenograft models. Supplemental Figure 4. MET can replace DPI for mitochondrial oxidative phosphorylation inhibition. Supplemental Figure S5. Effects of 24 h treatments of HK1-HK2+ OPM2 cells with HK2-ASO1, DPI, MET and PER, alone and in combination, on relative amounts of amino acids, TCA cycle metabolites, fatty acid intermediates, purines and pyrimidines. Supplemental Figure S6. Effect of 24 h treatments of HK1-HK2+ OPM2 cells with HK2-ASO1, DPI, MET and PER, alone and in combination, on relative 13C-labeled portions of TCA cycle metabolites, amino acids, purines, and pyrimidines. Supplemental Figure S7. In vitro and in vivo effects of mouse HK2 (mHK2) ASOs, as single agents and in combination with DPI, MET, and PER in mouse P3 (HK1-HK2+) and P3 (HK1+HK2+) isogenic MM cells.