Supplementary Figure S16 from Reprogramming of TLR–Ferroptosis Signaling and Immunometabolic Pathways Overcomes Myeloid Suppression to Improve Checkpoint Blockade in Prostate Cancer

Serum cytokine/chemokine analyses demonstrate PSMAi-C’ dots maintain a safe inflammatory profile relative to controls in the presence and absence of ICB. Proteome profiles of detectable cytokines and chemokines in serum from mice treated with saline, PSMAi-C' dots, ICB, and Dual Tx (a) 4 days and (b) 10 days following the final dose. All data are presented as mean ± s.e.m. (c) Corresponding body weights of mice over time (n = 5 per cohort). 1-way ANOVA with Tukey's multiple comparisons test was performed (***p < 0.005).