Supplementary Figures 1-10 from Cdx2 Expression and Intestinal Metaplasia Induced by H. Pylori Infection of Gastric Cells is Regulated by NOD1-Mediated Innate Immune Responses

Supplementary Figure 1. Cdx2 expression in human gastric epithelial cell lines. Supplementary Figure 2. The expression of Cdx2 was enhanced by H. pylori infection in gastric epithelial cell. Supplementary Figure 3. Scheme of the Cdx2 prmoter-luciferase reporter plasmids used in this study. Supplementary Figure 4. BAY11-7082 inhibits NF-κB activation. Supplementary Figure 5. NOD1 siRNA reduced the expression of NOD1. Supplementary Figure 6. Cdx2 and MUC2 expression in GSM06 cells. Supplementary Figure 7. Pretreatment with iE-DAP reduces H. pylori infection-induced Cdx2 expression. Supplementary Figure 8. iE-DAP alone does not alter Cdx2 expression. Supplementary Figure 9. Inflammatory scores of the stomach did not differ between NOD1-intact and NOD1-deficient mice. Supplementary Figure 10. TNF-α was induced in the stomachs of H. pylori-infected mice.