Supplementary Figures 1 - 9 from the Cancer Stem Cell Marker Aldehyde Dehydrogenase is Required to Maintain a Drug-Tolerant Tumor Cell Subpopulation

PDF file - 1635KB, Elevated ALDH1A1 activity in KATO II and GTL-16 DTPs (S1). ALDHhigh cells exhibit properties similar to CSCs (S2). Effect of DS on growth of parental cells and DTPs (S3). DS has opposite effects on pre- and post- KI-treated cells (S4). ALDH family members are expressed at higher level in DTPs (S5). Role of specific ALDH isoforms and cell density in drug tolerance drug (S6). Effect of the alternative ALDH inhibitor gossypol on drug-tolerant cells (S7). Increased mitochondrial respiration and ROS levels in KATO II ALDHhigh cells (S8). DS effect is not mediated by inhibition of efflux pumps or through proteasome inhibition (S9).