Supplementary Table 2 shows the distribution of the clinical variables across the four proteomic-based clusters. Gln61Arg: Glutamine to Arginine at position 61, Gln61His: Glutamine to Histidine at position 61, Gly12Ala: Glycine to Alanine at position 12, Gly12Arg: Glycine to Arginine at position 12, Gly12Asp: Glycine to Aspartic Acid at position 12, Gly12Cys: Glycine to Cysteine at position 12, Gly12Leu: Glycine to Leucine at position 12, Gly12Val: Glycine to Valine at position 12. Note that all patients showed positivity for COSMIC signature 1, while no patients showed positivity for COSMIC signatures 6, 20, 25, and 26. For COSMIC signatures 13, 18, 28, and 30, only one patient was in the positive group.