Comparison of t-TMB and CNV scores by clinicopathologic variables in overall cohort. Data shown as median (range) or n (%) for continuous and categorical variables, respectively. Wilcoxon Rank-Sum and Kruskal-Wallis tests used for comparison of categorical and continuous variables, respectively. Additionally, we saw no correlation between primary tumor Breslow depth (mm) and t-TMB (Pearson’s r = -0.131, [95% CI: - 0.412 – 0.173], p = 0.397) or CNV score (Pearson’s r = -0.102, [95% CI: - 0.387 – 0.201], p = 0.511). a Data for primary tumor LVI and Breslow depth available for 45 of 54 (83.3%) patients.