Introduction: Pancreatic cancer is the third leading cause of cancer death after lung and colorectal cancer and its diagnosis is often difficult to make in the early stages. Investigations such as echoendoscopy are an asset in the diagnostic arsenal of the medical-surgical team. Method: We propose for presentation a case of a patient who, at reevaluation one year after cholecystectomy, presents a cephalopancreatic tumor so he was proposed for duodenopancreatectomy following the decision of an interdisciplinary medical-surgical team. Results: A 69-year-old patient with a history of mediocoledocian stenosis for which biliary and pancreatic stents were fitted endoscopically, presents at the hospital with clinical signs suggestive of acute cholecystitis. Surgery is decided and an open cholecystectomy is performed for plastronated pyocholecystitis. Intraoperatively, it was observed an accentuated pericephalopancreatic inflammation, but it is not considered to be with a tumoral substrate. Subsequently, at approximately 1 year, CT scan is performed and suggests a cephalopancreatic tumor, so an echoendoscopy with biopsy was performed and the histopathological result was high-grade intraepithelial ductal pancreatic neoplasia. Following the multidisciplinary consultation within the tumor board, the patient is proposed for duodenopancreatectomy. Conclusion: Pancreatic neoplasm, although an extremely difficult pathology from the point of view of diagnosis and treatment, can and must be managed in multidisciplinary medical-surgical teams both in terms of medical expertise and investigations. Such therapeutic decisions are presented within specialized tumor boards, the oncological surgical treatment being an ample one.