SYNTHESIS AND ANTI BACTERIAL EVALUATION OF NOVEL (4-(2-FLUORO-4-(1H-1,2,3,-TRIAZOL-1-YL)PHENYL)PIPERAZIN-1-YL)KETONE ANALOGUES

Encouraged by the various pharmacological and biological importance on triazole hybrids in this work, we have designed a simple synthetic method for the synthesis of novel (4-(2-fluoro-4-(1H-1,2,3,-triazol-1-yl)phenyl)piperazin-1-yl)ketone derivatives (7a-j), evaluated for in vitro antibacterial targets. The antibacterial screening outcomes revealed the prepared compounds showed good antibacterial activity. Among the synthesized compounds 7d, 7i, and 7j displayed noteworthy anti-bacterial activity. The tetrazole hybrid 7j exhibited superior inhibition of Enterobacter aerogenes and Bacillus subtilis pathogens with MIC values of 113 +/- 0.68and 73 +/- 1.92 & micro;g/mL respectively. The molecule 7c is most effective against Enterobacter aerogenes, Bacillus subtilis with consecutive MIC's of 128 +/- 1.88 & micro;g/mL and 91 +/- 1.74 & micro;g/mL.