Targeting RAS Regulation

CancerThe RAS signaling pathway controls cell survival and proliferation and is a possible target for cancer treatment. However, therapeutically targeting RAS is challenging. In a Perspective, Bivona discusses recent studies that identify upstream targets, the inhibition of which could suppress RAS signaling in cancer. Certain cancer-associated RAS pathway alterations leave RAS sensitive to regulation by signaling adaptors. Preclinical studies suggest that this regulation can be targeted to prevent RAS signaling and thus tumor progression.Science , this issue p. [1280][1] [1]: /lookup/doi/10.1126/science.aav6703