The Association Between Angiographically Derived Radial Wall Strain and the Risk of In-Stent Restenosis.

In-stent restenosis (ISR) remains a major stent failure post-PCI. This study aimed to explore the predictive capability of pre-PCI baseline angiographically-derived radial wall strain (RWS) for the development of ISR in self-controlled patients. In this retrospective self-controlled study, we included 64 patients (146 stented lesions) with multivessel PCI in whom at least one vessel developed ISR and at least one remained free of ISR, allowing within-patient comparison. Pre-PCI baseline RWS was measured for all stented lesions in each patient. Lesion-level maximal RWS (RWSmax) was defined as the highest RWS in the stenotic segment. The incremental discriminant and reclassification abilities for ISR prediction were compared between 2 models (Model 1: Angiography Characteristics + Stent Characteristics; Model 2: Model 1 + RWSmax). Among all lesions, 76 (52.1