The Brain’s Action-Mode Network

The brain is always intrinsically active, using energy at high rates while cycling through global functional modes. Awake brain modes are tied to corresponding behavioural states. During goal-directed behaviour, the brain enters an action-mode of function. In the action-mode, arousal is heightened, attention is focused externally and action plans are created, converted to goal-directed movements and continuously updated on the basis of relevant feedback, such as pain. Here, we synthesize classical and recent human and animal evidence that the action-mode of the brain is created and maintained by an action-mode network (AMN), which we had previously identified and named the cingulo-opercular network on the basis of its anatomy. We discuss how rather than continuing to name this network anatomically, annotating it functionally as controlling the action-mode of the brain increases its distinctiveness from spatially adjacent networks and accounts for the large variety of the associated functions of an AMN, such as increasing arousal, processing of instructional cues, task general initiation transients, sustained goal maintenance, action planning, sympathetic drive for controlling physiology and internal organs (connectivity to adrenal medulla), and action-relevant bottom–up signals such as physical pain, errors and viscerosensation. In the functional mode continuum of the awake brain, the AMN-generated action-mode sits opposite the default-mode for self-referential, emotional and memory processing, with the default-mode network and AMN counterbalancing each other as yin and yang. The brain enters an action-mode of function during goal-directed behaviour. In this Perspective, Dosenbach, Raiche and Gordon describe “action-mode” as an informative functional label that reduces anatomical network naming confusion, then characterize how the reannotated action-mode network supporting it counterbalances the default mode network.