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The Cellular Thermal Shift Assay for Evaluating Drug Target Interactions in Cells. | AMiner

The Cellular Thermal Shift Assay for Evaluating Drug Target Interactions in Cells.

Rozbeh Jafari,Helena Almqvist,Hanna Axelsson,Marina Ignatushchenko,Thomas Lundbäck,Pär Nordlund,Daniel Martinez Molina

Nature Protocols（2014）SCI 1区

Department of Medical Biochemistry and Biophysics

被引用1021|浏览62

摘要

Interaction between a drug and its protein target results in a shift in thermal stability of that protein. The cellular thermal shift assay–CETSA–exploits this to characterize intracellular drug-protein engagement.

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关键词

Biochemical assays,Pharmacology,Proteins,Target validation,Life Sciences,general,Biological Techniques,Analytical Chemistry,Microarrays,Computational Biology/Bioinformatics,Organic Chemistry

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