The Regulation of IL ‐ 10 Production by Immune Cells

| Interleukin‐10 (IL‐10), a cytokine with anti‐inflammatory properties, has a central role in infection by limiting the immune response to pathogens and thereby preventing damage to the host. Recently, an increasing interest in how IL10 expression is regulated in different immune cells has revealed some of the molecular mechanisms involved at the levels of signal transduction, epigenetics, transcription factor binding and gene activation. Understanding the specific molecular events that regulate the production of IL‐10 will help to answer the remaining questions that are important for the design of new strategies of immune intervention. R E V I E W S NATuRe RevIewS | Immunology ADvANCe oNLINe puBLICATIoN | 1 Nature Reviews Immunology | Aop, published online 15 February 2010; doi:10.1038/nri2711 © 20 Macmillan Publishers Limited. All rights reserved 10