To Fuse, or Not to Fuse: Closing in on the Nuclear Envelope Fusion Machinery.

Nuclear pore complex assembly is an intricate process occurring in the double bilayer of the nuclear envelope. In this issue of Molecular Cell, Fischer et al.,1 Maslennikova et al.,2 and Wang et al.3 integrate genetic analysis across model organisms with functional studies and molecular simulations to better understand a key step-membrane fusion.