Towards 3D-Oid Models That Integrate Molecular, Morphological and Spatial Cellular Features

Methods to study cellular omics, morphology and spatial context evolved independently, yet evidence shows their integration outperforms single-methodology analyses. In this Comment, we propose that use of next-generation 3D-oids that combine molecular, morphological and spatial information will promote tissue analyses and bring us closer to engineering functional organs. Combined analyses of cellular omics, morphology and spatial context in 3D-oids would advance tissue studies and organ engineering.