Understanding hormonal mechanisms of obesity-related hypertension may inform targeted therapy. Participants with obesity and hypertension underwent deep-phenotyping procedures to detect the primary aldosteronism phenotype, low-renin phenotype, renin-dependent aldosteronism phenotype, and ACTH-independent hypercortisolism. In total, 51.9% of participants had a primary aldosteronism phenotype, of which approximately one-half also had superimposed renin-dependent aldosteronism. Another 23.4% of participants had only renin-dependent aldosteronism that was characterized by higher aldosterone levels and kaliuresis, and 9.2% of participants also had hypercortisolism. Over 80% of individuals with obesity-related hypertension exhibited overlapping pathologic phenotypes of aldosteronism and/or hypercortisolism, providing mechanistic evidence to support the efficacy of aldosterone- and cortisol-directed therapy.
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