Luteinizing hormone (LH) secreted from the anterior pituitary, signals Leydig cells of the testes to produce testosterone. A common genetic variant of LH (vLH) has been identified. The prevalence of vLH allele has been estimated worldwide as a carrier frequency of 0% to 53% of Caucasians and is known to be more active than the wild-type protein. Screening for vLH has primarily relied on relative immunoreactoivity in variant-sensitive and insensitive assays. In addition, restriction fragment length polymorphism (RFLP) studies are largely been used to confirm immunoassay results. However, both methods present various limitations and potential bias. We hypothesized that vLH might affect the susceptibility to prostate cancer and we aim to study its relation with the disease in men of different ethnic origins.
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