The field of reptile infectious disease epidemiology continues to grow and evolve, revealing a diverse variety of viruses, bacteria, fungi, and parasites. Many of these organisms go beyond being opportunistic agents and serve as true obligate pathogens, with some being responsible for mortality events worldwide. Our knowledge about their classification, diagnosis, treatment, and management is continually being updated, so it is imperative for veterinarians working with reptiles to remain vigilant. Ultimately, our success with captive reptiles requires us to continue to refine our understanding of these pathogens to ensure we can protect the health and welfare of our reptile populations.