NOVELTY - Amine compound is new.
USE - In a pharmaceutical composition (claimed); for treating inflammatory disorders, rheumatoid arthritis, inflammatory bowel disease, asthma, chronic obstructive pulmonary disease, osteoarthritis, atopic dermatitis, psoriasis, vascular proliferative disorders, atherosclerosis, restenosis, apoptosis, proliferative ocular disorders, diabetic retinopathy, benign proliferative disorders, autoimmune diseases, multiple sclerosis, tissue and organ rejection, neurodegenerative disorders, Alzheimer's disease, Parkinson's disease, motor neurone disease, neuropathic pain, triplet repeat disorders, alcoholic liver disease, ischemic injury, stroke, cachexia, fever, acidosis, HIV infection, cancer, endocrinopathies, solid tumors.
ADVANTAGE - The compound has excellent ability to inhibit proteasome-mediated peptide hydrolysis or protein degradation.
DETAILED DESCRIPTION - Amine compound of formula (I) is new.
Z1+Z2=boronic acid complexing agent;
A1=group of formulae (i)-(xxi).