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    一种气泡剥离装置及电镀液电镀系统

    12699008386B1
    发明人
    张雷
    受让人
    XIAMEN TONGFU MICROELECTRONICS CO LTD (XIAM-Non-standard)
    申请人
    CANADIAN KODAK CO
    申请号
    2215451
    申请日
    2008-09-16
    公开(公告)号
    12699008386B1
    公开(公告)日
    2024-10-09
    IPC分类号
    F16L59/16
    CPC分类号
    -
    优先权号
    112910
    2356690
    优先权日
    1972-11-12
    1973-11-12
    摘要

    NOVELTY - Substituted phenylethynyl-thiophene based derivatives (I) are new.

    USE - For treating an MMP mediated condition and dieases, where the condition is selected from enhanced or exaggerated sensitivity to pain (such as hyperalgesia, causalgia and allodynia); acute pain; burn pain; atypical facial pain; neuropathic pain; back pain; complex regional pain syndromes I and II ; arthritic pain; sports injury pain; pain related to viral infection (such as HIV pain, post-polio syndrome and post-herpetic neuralgia); phantom limb pain; labor pain; cancer pain; post-chemotherapy pain; post-stroke pain; post-operative pain; physiological pain; inflammatory pain; acute inflammatory conditions; visceral pain (such as angina, irritable bowel syndrome (IBS) and inflammatory bowel disease); painful diabetic neuropathy; traumatic nerve injury; spinal cord injury; paralysis; aging; reperfusion injury; trauma; chemical exposure or oxidative damage to tissues; wound healing; skin beautifying; osteoarthritic pain; and tolerance to narcotics or withdrawal from narcotics. The MMP mediated disease is selected from rheumatoid arthritis, osteoarthritis, abdominal aortic aneurysm, cancer, inflammation, atherosclerosis, multiple sclerosis, chronic obstructive pulmonary disease, ocular diseases, neurological diseases, psychiatric diseases, thrombosis, bacterial infection, Parkinson's disease, fatigue, tremor, diabetic retinopathy, vascular diseases of the retina, dementia, cardiomyopathy, renal tubular impairment, diabetes, psychosis, dyskinesia, pigmentary abnormalities, deafness, inflammatory and fibrotic syndromes, intestinal bowel syndrome, allergies, Alzheimer's disease, arterial plaque formation, periodontal disease, viral infection, stroke, cardiovascular disease, hemorrhoid and disease causing pain (all claimed).

    ADVANTAGE - The compound (I) exhibits increased potency, metabolic stability and reduced toxicity in relation to currently known MMP inhibitor for the treatment of pain and other dieases such as cancer; and shows inhibition activity of MMP-2 and MMP-9 at IC50 value of 1 nM to 20 mu M (preferably 1 nM to 2 mu M).

    DETAILED DESCRIPTION - Substituted phenylethynyl-thiophene based derivatives of formula (I) or their N-oxides, salts, prodrugs, formulations, polymorphs, tautomers, racemic mixtures or stereoisomers, are new.

    R1-R8, R10, R11=H, D, halo, alkyl, cycloalkyl, heterocycloalkyl, bicycloalkyl, heterobicycloalkyl, spiroalkyl, spiroheteroalkyl, aryl, heteroaryl, cycloalkyl fused aryl, heterocycloalkyl fused aryl, cycloalkyl fused heteroaryl, heterocycloalkyl fused heteroaryl, cycloalkylalkyl, heterocycloalkylalkyl, bicycloalkylalkyl, heterobicycloalkylalkyl, spiroalkylalkyl, spiroheteroalkylalkyl, arylalkyl, heteroarylalkyl, cycloalkyl fused arylalkyl, heterocycloalkyl fused arylalkyl, cycloalkyl fused heteroarylalkyl, heterocycloalkyl fused heteroarylalkyl, heterocycloalkyl, bicycloalkyl, heterobicycloalkyl, spiroalkyl, spiroheteroalkyl, aryl, heteroaryl, cycloalkyl fused aryl, heterocycloalkyl fused aryl, cycloalkyl fused heteroaryl, heterocycloalkyl fused heteroaryl, cycloalkylalkyl, hydroxy, alkoxy, alkenyl, alkynyl, NO2, NR9R9, NR9NR9R9, NR9N=CR9R9, NR9SO2R9, CN, C(O)OR9, or fluoroalkyl, where alkyl, cycloalkyl, alkoxy, alkenyl, alkynyl, fluoroalkyl and heterocycloalkyl fused heteroarylalkyl are at least one time optionally substituted;

    X=COOH, PO3H (sic), COOD, or PO3D (sic);

    Y'=H, alkyl, cycloalkyl, heterocycloalkyl, bicycloalkyl, heterobicyclo, heterobicycloalkyl, spiroalkyl, spiroheteroalkyl, aryl, heteroaryl, cycloalkyl fused aryl, heterocycloalkyl fused aryl, cycloalkyl fused heteroaryl, heterocycloalkyl fused heteroaryl, cycloalkylalkyl, heterocycloalkylalkyl, bicycloalkylalkyl, heterobicycloalkylalkyl, spiroalkylalkyl, spiroheteroalkylalkyl, arylalkyl, heteroarylalkyl, cycloalkyl fused arylalkyl, heterocycloalkyl fused arylalkyl, cycloalkyl fused heteroarylalkyl, heterocycloalkyl fused heteroarylalkyl, fluoroalkyl, fluorobicyclo, or fluoroheterobicylco;and

    R9=H, deuterium, alkyl, cycloalkyl, heteroaryl, arylalkyl or fluoroalkyl.

    INDEPENDENT CLAIMS are included for a composition comprising (I) and a carrier; or (I), a carrier, and a member selected from disease modifying antirheumatic drug, a nonsteroidal anti-inflammatory drug, a cyclooxygenase-2 (COX-2) selective inhibitor, a cyclooxygenase-1 (COX-1) inhibitor, an immunosuppressive, a steroid, a biological response modifier, and a small molecule inhibitor of pro-inflammatory cytokine production.

    权利要求
    or a pharmaceutically acceptable salt thereof, wherein a is a single or double bond; m is 1; L is a bond, —CH═CH— or —C≡C—; Q is substituted or unsubstituted pyridyl; R 1 is hydrogen, C 1 -C 4 alkyl, C 1 -C 4 haloalkyl, —C(O)—C 1 -C 4 alkyl, —C(O)—C 1 -C 4 haloalkyl, —C(O)O—C 1 -C 4 alkyl, —C(O)O—C 1 -C 4 haloalkyl, or —C(O)NR e —C 1 -C 4 alkyl; R e is hydrogen or alkyl; wherein Q, when substituted, is independently substituted with 1, 2, 3, 4, or 5 substituents, wherein the substituent is halogen, cyano, C 1 -C 5 haloalkyl, C 1 -C 5 alkyl, C 2 -C 5 alkenyl, C 2 -C 5 alkynyl, hydroxy, C 1 -C 5 alkoxy, —O—C 1 -C 5 haloalkyl, —S—C 1 -C 5 alkyl, —S—C 1 -C 5 haloalkyl, —SO 2 —C 1 -C 5 alkyl, —SO 2 —C 1 -C 5 haloalkyl, C 1 -C 5 cyanoalkyl, or —NO 2 .
    2. The compound of claim 1 , wherein Q is pyridin-3-yl, pyridin-4-yl, or 6-methylpyridin-3-yl.
    3. The compound of claim 1 , wherein R 1 is C 1 -C 4 alkyl or C 1 -C 4 haloalkyl.
    4. The compound of claim 1 , wherein R 1 is —C(O)—C 1 -C 4 alkyl or —C(O)—C 1 -C 4 haloalkyl.
    5. The compound of claim 1 , wherein R 1 is —C(O)O—C 1 -C 4 alkyl, —C(O)O—C 1 -C 4 haloalkyl or —C(O)NR e —C 1 -C 4 alkyl.
    6. The compound according to claim 1 or a pharmaceutically acceptable salt thereof, selected from the group consisting of: 2-methyl-6-[(E)-2-(6-methylpyridin-3-yl)vinyl]-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole; 2-methyl-6-[(6-methylpyridin-3-yl)ethynyl]-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole; 2-methyl-6-(pyridin-3-ylethynyl)-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole; 2-methyl-6-(pyridin-4-ylethynyl)-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole; 6-[(E)-2-(6-methylpyridin-3-yl)vinyl]-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole; 2-acetyl-6-[(E)-2-(6-methylpyridin-3-yl)vinyl]-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole; (cis)-2-methyl-6-[(E)-2-(6-methylpyridin-3-yl)vinyl]-2,3,4,4a,5,9b-hexahydro-1H-pyrido[4,3-b]indole; ethyl 6-[(E)-2-(6-methylpyridin-3-yl)vinyl]-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indole-2-carboxylate; and N-ethyl-6-[(E)-2-(6-methylpyridin-3-yl)vinyl]-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indole-2-carboxamide.
    7. A pharmaceutical composition comprising a therapeutically effective amount of a compound of formula (I) according to claim 1 .
    8. A pharmaceutical composition comprising a therapeutically effective amount of a compound of formula (I) according to claim 1 or a pharmaceutically acceptable salt thereof, in combination with a pharmaceutically acceptable carrier.
    说明书
    [0001]CROSS-REFERENCE TO RELATED APPLICATIONS
    [0002]Pursuant to 35 U.S.C. §119(a), this application claims the benefit of earlier filing date and right of priority to Korean Application No. 10-2007-0036757, filed on Apr. 16, 2007, the contents of which are hereby incorporated by reference herein in their entirety.
    [0003]FIELD OF THE INVENTION
    [0004]The present invention is directed to multi-tasking and displaying an active cursor in a mobile terminal.
    [0005]DESCRIPTION OF THE RELATED ART
    [0006]Recently, a mobile terminal has been developed to achieve a high processing speed and a high memory capacity to support multitask operations. The mobile terminal with multitask capability processes and displays a most recently executed application on top of a display or in a foreground while processing and displaying other executed applications previously initiated in a background. The mobile terminal with multitask capability displays, for example, a Background Music (BGM) indicator to indicate that an MPEG-1 Audio layer 3 (MP3) file is being reproduced in the background when another application is being executed in the foreground.
    [0007]SUMMARY OF THE INVENTION
    [0008]In one general aspect, a method of multi-tasking in a mobile terminal includes displaying a first task display associated with a first application task in the mobile terminal, receiving a request to execute a second application task while the first application task is being performed, and displaying a second task display, the second task display associated with the second application task and at least partially replacing the first task display, wherein at least a portion of the second task display is identified by an active cursor configured to allow a user to select a function associated with the second application task and at least one display feature of the active cursor indicates that the first application task is concurrently being performed.
    [0009]In one embodiment, the second task display includes a menu list corresponding to the second application task, at least one item of the menu list identified by the active cursor. The display feature of the active cursor may include at least one of color, color tone and fading. Additionally, the display feature of the active cursor may include at least one of still and moving images.
    [0010]In another embodiment, the first application task includes an MP3 file reproduction function and the moving images move in response to a tempo of music played via the MP3 file reproduction function.
    [0011]In another embodiment, the active cursor includes at least one additional display feature that corresponds to at least one additional application task being performed concurrently with the first and the second application tasks. The additional display feature may be selectively determined by the user.
    [0012]Preferably, the active cursor includes status information associated with the first application task. The status information may include one of text information and a progressive bar graph. The display feature of the active cursor may be initiated a predetermined time after displaying the second task display.
    [0013]In another aspect, a terminal includes an input unit for receiving a request to perform a first application task and a request to perform a second application task, the request to perform the second application task received while the first application task is being performed; a display for displaying a first task display associated with the first application task and a second task display associated with the second application task, the second task display at least partially replacing the first task display; and a controller for displaying an active cursor on the second task display, wherein at least one display feature of the active cursor indicates that the first application task is being concurrently performed.
    [0014]BRIEF DESCRIPTION OF THE DRAWINGS The above and other features and advantages of the present invention will become more apparent by describing in detail preferred embodiments thereof with reference to the attached drawings. FIG. 1 is a block diagram illustrating an exemplary mobile communication terminal according to an embodiment of the present invention. FIGS. 2 and 3 illustrate screens displaying cursors according to an embodiment of the present invention. FIGS. 4A and 4B illustrate screens displaying active cursors according to an embodiment of the present invention. FIGS. 5 and 6 illustrate screens displaying active cursors according to another embodiment of the present invention. FIGS. 7A and 7B illustrate screens displaying active cursors according to yet another embodiment of the present invention.
    [0015]DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS
    [0016]In the following detailed description, reference is made to the accompanying drawing figures which form a part hereof, and which show by way of illustration specific embodiments of the invention. It is to be understood by those of ordinary skill in this technological field that other embodiments may be utilized, and structural, electrical, as well as procedural changes may be made without departing from the scope of the present invention. Wherever possible, the same reference numbers will be used throughout the drawings to refer to the same or similar parts.
    [0017]Referring to FIG. 1 , a mobile communication terminal 100 according to the present invention includes a transceiver 10 , a memory unit 20 , an input unit 30 , a controller 40 , a display 50 , and an audio processor 60 .
    [0018]The transceiver 10 transmits and receives signals to and from a base station (not shown) to perform a communication function for the mobile communication terminal 100 .
    [0019]The memory unit 20 stores programs and data for controlling overall operations of the mobile communication terminal 100 . The memory unit 20 further stores files such as MP3 files, video files, and image files. The memory unit 20 may also store a program for a real-time operating system to support multitask operations of the mobile communication terminal 100 .
    [0020]The input unit 30 includes various buttons for inputting information such as numbers and characters. The input unit 30 further includes function buttons for manipulating various functions and direction buttons for selecting a specific direction to move a cursor. The input unit 30 is implemented as a key pad, a touchpad, a jog dial, a touch screen, or a joystick. The input unit 30 receives a command from a user to perform a specific task by transferring the input command to the controller 40 .
    [0021]The controller 40 is a processor that performs overall control operations of the mobile communication terminal 100 based on the programs and data stored in the memory unit 20 . The controller 40 controls and manages the multitask operations using the program for the real-time operating system stored in the memory unit 20 .
    [0022]For example, the controller 40 manages to execute a plurality of tasks in parallel based on a priority preset according to factors such as their urgency and importance. The controller 40 receives a command to operate the specific task from the input unit 20 while operating another task such as reproducing or downloading certain contents.
    [0023]Accordingly, the controller 40 performs multitask operations to perform the specific task in the foreground and display a screen related to the specific task on the display 50 . The controller 40 also displays an active cursor on the screen related to the specific task in the foreground to visually indicate that another task is being performed in the background. For example, the active cursor may indicate that certain contents are being reproduced or downloaded in the background.
    [0024]The display 50 displays on a screen a variety of information output from the mobile communication terminal 100 . The screen may include a menu screen. The display 50 may include a Liquid Crystal Display (LCD) or an Organic Light Emitting Diode (OLED).
    [0025]The display 50 may include more than one display devices, such as an external display device and an internal display device. The display 50 may display an active cursor under the control of the controller 40 . The active cursor may display in its interior at least one graphic pattern such as a rhythmical motion.
    [0026]The audio processor 60 processes audio signals decoded by the controller 40 to output specific sound through a speaker SPK under the control of the controller 40 . The audio processor 60 further processes audio signals from a microphone MIC to transmit the processed audio signals to the controller 40 .
    [0027]Referring to FIG. 2 , cursors 220 , 240 , and 260 are shown on screens 210 , 230 , and 250 , respectively, of the display 50 of the mobile communication terminal 100 . A cursor generally refers to a pointer, a moving icon or position markers of the pointing device. In a graphical user interface as often used in the mobile communication terminal 100 , the cursor is often a blinking line or bar that is used to indicate which submenu or item in a menu or list is selected by highlighting or distinguishing the selected submenu or item from other submenus or items. In general, the cursor is monotonous and displayed in a single solid color. In the present invention, an “active cursor” is distinguished from the common cursor and is characterized by changing colors, or graphic image/motion of waves or bubbles in the cursor.
    [0028]In FIG. 2 , a ‘Multimedia’ 220 is selected from an initial ‘MENU’ screen 210 showing a list of submenus. Then, a ‘MULTIMEDIA’ 230 menu screen showing a list of a plurality of the multimedia submenus is displayed on the display 50 . An ‘MP3 player’ menu 240 , for example, is selected from the ‘MULTIMEDIA’ 230 menu screen. As a result, the mobile communication terminal 100 transitions to an ‘MP3’ 250 play mode and displays a list of MP3 files stored in the memory unit 20 on the display 50 .
    [0029]In the list of the MP3 files displayed on the display 50 , the user moves a cursor to a desired MP3 file, for example, ‘Dream Lover’ 260 , and selects a ‘PLAY’ menu 270 to play the selected MP3 file. Alternatively, the display 50 may be a touch screen and tapping on the name of the desired MP3 file, for example, ‘Dream Lover’ 260 , will play the tapped file.
    [0030]After the MP3 file is selected as described above in connection with FIG. 2 , the display 50 displays a play screen 310 , as shown in FIG. 3 , to play the selected MP3 file. Referring to FIG. 3 , the user may further request to perform another task while the MP3 file is being played.
    [0031]Another task is then executed in the foreground while the MP3 file is being played in the background. For example, the user may request to enter a message mode by manipulating the input unit 30 while the MP3 file is being played as shown in the play screen 310 . In response to the user's input, the mobile communication terminal 100 transitioned to the message mode to display a ‘Messaging’ menu screen 320 A showing a list of message submenus such as ‘New Message’, ‘Inbox’, ‘Drafts’, and ‘Outbox’ on the foreground while the MP3 file is being played in the background.
    [0032]On the displayed list of message submenus, a cursor 330 for selecting a desired menu is placed on one of the message submenus. The message menu screen 320 A may display in an indicator area 340 a ‘BGM’ indicator to indicate that the MP3 file is being played in the background.
    [0033]After a predetermined time lapses, for example 0.1 second, the message menu screen 320 A may be changed into a modified screen 320 B. In the modified screen 320 B, the initial cursor 330 of the initial message menu screen 320 A has been changed into an active cursor 350 having at least one graphic pattern displaying a rhythmical motion, for example, a pattern with polka dots in rhythmical movements.
    [0034]FIGS. 4A and 4B illustrate screens displaying examples of active cursors. As described above, the mobile communication terminal 100 may change the cursor 330 into the active cursor 350 having a specific pattern with rhythmic motions if the MP3 file is being played in the background while the multitask processing is performed. Therefore, from the specific pattern of the active cursor 350 , the user may instantly notice that the MP3 file is being played in the background.
    [0035]The described implementation is merely exemplary, and many variations may be applied to the implementation. For example, the active cursor 350 may be displayed to inform that a moving picture is being reproduced or a specific file is being downloaded in the background while another task is performed in the foreground.
    [0036]According to the above description, the cursor 330 is displayed on the screen 320 A for processing the new task and then changed into the active cursor 350 after the predetermined time has lapsed after initiating the multitask processing. Alternatively, the active cursor 350 may be displayed instantly upon initiating the new task and the screen 320 B for the new task displayed on the display 50 .
    [0037]Referring to FIG. 5 , the mobile communication terminal 100 transitions to the message mode to display a message menu screen 510 A while playing the MP3 file. The message menu screen 510 A shows the list of message submenus with the active cursor 540 placed at one of the menus in the list.
    [0038]If the user selects a ‘CURSOR’ menu 520 at a lower end of the message menu screen 510 A under the list of the message submenus, a popup window 530 is displayed on the message menu screen 510 A. The popup window 530 provides a ‘Music information Display’ menu and a ‘Tempo Control’ menu.
    [0039]If the user places a cursor at the ‘Music information Display’ menu and presses a ‘SELECT’ menu on the left side of the ‘CURSOR’ menu 520 , submenus, such as a ‘Setting’ and a ‘Cancel’ menu, are displayed in another popup window on the left side of the popup window 530 . If the user selects the ‘Setting’ menu, the ‘Messaging’ menu screen 510 A is turned into a screen 510 B in which the active cursor 550 displays a name of the MP3 file being played within the active cursor 550 . For example, ‘Inbox/Dream Lover’ is displayed within the active cursor 550 while the MP3 file of ‘Dream Lover’ is being played in the background.
    [0040]If the user moves the cursor to the ‘Tempo Control’ menu in the popup window 530 and presses the ‘SELECT’ menu, submenus, such as an ‘Automatic,’ a ‘Manual,’ and a ‘Cancel’ menu, are displayed in another popup window on the left side of the popup window 530 on the message menu screen 510 C. If the ‘Automatic’ menu is selected, a tempo of the motion of the pattern displayed within the active cursor 540 may be adjusted in accordance with a tempo of the MP3 file being reproduced. For example, the pattern may move in a faster tempo if the tempo of the MP3 file increases.
    [0041]If the ‘Manual’ menu is selected, the user may set the tempo of the motion of the pattern in the active cursor 540 to one of available predetermined tempos and the tempo of the displayed motion will be constant regardless of the variation of the tempo in the MP3 file being played. For example, the predetermined tempo of the motion of the pattern may be available as ‘very slow,’ ‘slow,’ ‘normal,’ ‘fast,’ or ‘very fast.’
    [0042]If the user selects the ‘Cancel’ menu in the popup window 530 , the pattern displayed in the active cursor 540 may move in a predetermined tempo set by the mobile communication terminal 100 .
    [0043]According to the above description, when the user selects the ‘Music Info Display’ menu, the name of the MP3 file is displayed within the active cursor 540 . Alternatively, information regarding the MP3 file, such as lyrics, artist information or a play order of the MP3 files may be displayed within the active cursor 540 .
    [0044]Referring to FIG. 6 , if the user selects a connection to the Internet in order to download specific content, the display 50 displays a screen 610 showing a list of contents available for download. If the user moves the cursor to a desired content in the list and presses the ‘SELECT’ menu, the display 50 displays a screen 620 to indicate that the selected content is being downloaded.
    [0045]If the user selects the message mode while the selected content is being downloaded, the mobile communication terminal 100 transitions to the message mode and displays a ‘Messaging’ menu screen 630 A showing a list of message submenus in the foreground while downloading the desired content in the background. A cursor 640 may be placed on any one of the message submenus listed in the ‘Messaging’ menu screen 630 A.
    [0046]A progressive bar 650 may be displayed inside the cursor 660 after a predetermined time has lapsed, in a manner similar to screen 630 B in order to show the progress of the download. Therefore, the user is able to check the progress of the download in the message mode.
    [0047]As described above, the mobile communication terminal 100 may change the cursor 640 to display the progressive bar 650 within the cursor 660 after the predetermined time has lapsed. Alternatively, the cursor 660 may display the progressive bar 650 as soon as the message menu screen 630 A is displayed in the foreground in response to the user's command.
    [0048]Further, rather than displaying the progressive bar 650 within the cursor 660 , the cursor 670 itself may be implemented as a progressive bar to show the progress of the downloading as in a screen 630 C shown in FIG. 7A . Furthermore, as illustrated by the cursor 680 displayed on a ‘Messaging’ menu screen 630 D in FIG. 7B , the cursor 680 may be implemented as a progressive bar having a pattern with a rhythmical motion similar to that illustrated in FIGS. 3 and 4 .
    [0049]The foregoing embodiments and advantages are merely exemplary and are not to be construed as limiting the present invention. The present teaching can be readily applied to other types of apparatuses and processes. The description of the present invention is intended to be illustrative, and not to limit the scope of the claims. Many alternatives, modifications, and variations will be apparent to those skilled in the art.
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