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    专

    一种生产L-组氨酸的基因工程菌及其应用

    KR2015536085B1
    发明人
    谢希贤, 樊伟明, 吴鹤云, 蒋卫, 田道光, 陈燕娜, 张悦, 屠建情
    受让人
    ZHEJIANG ZHENYUAN PHARM CO LTD (ZHEJ-Non-standard), UNIV TIANJIN SCI & TECHNOLOGY (UYTC-C)
    申请人
    WICKMAN MACH TOOL SALES LTD
    申请号
    201810092576
    申请日
    2010-10-05
    公开(公告)号
    KR2015536085B1
    公开(公告)日
    2000-08-22
    IPC分类号
    H01P007/06H01P007/04
    CPC分类号
    -
    优先权号
    006501
    优先权日
    1998-01-15
    摘要

    NOVELTY - Conventionally, the bit rate of a voiceless part of a voice signal is lowered distinguishing the voiceless part from the voiced part; according to the invention, the bit rate of the voiced part is also lowered. The voiced part is constituted of a vowel sound and a consonant sound. The vowel sound can be reproduced with almost no degradation of the quality by reproducing the vocal track component and the pitch component even if the encoding bit rate of the other components is lowered. Therefore, when the vowel sound of the voiced part is encoded, the average bit rate when the voiced part is sounded is lowered by reducing the encoding bits of a noise code book and by lowering the bit rate to a half rate. To discriminate a vowel sound, the relation between the LPC spectrum and the LSP coefficients is used. The vowel sound has high peaks in the LPC spectrum, and the LSP coefficients are present on both sides of the peaks. Therefore, when adjacent LSP coefficients are clos er to each other than a predetermined threshold, it is judged that a peak is present. Such judgment is made for some of the peaks, thereby judging whether or not the sound is a vowel.

    USE - Rate control device for variable-rate voice encoding system

    DESCRIPTION OF DRAWING(S) - Autocorrelation function coefficient calculating section (10)

    LPC calculating section (12)

    Rate determining section (11)

    LPC-LSP converting section (13)

    LSP quantizing section (14)

    Voiced sound rate control section (20)

    LSP-LPC converting section (15)

    Residual signal calculating section (16)

    Adaptive code book searching section (17)

    Noise code book searching section (18)

    Gain quantizing section (19)

    权利要求
    1. A method for targeting a therapeutic agent to solid tumor tissue in a subject, wherein the solid tumor tissue is characterized by overexpression of HER-2, comprising attaching a therapeutic agent to an isolated polypeptide comprising the amino acid sequence of SEQ ID NO:1, or a fragment of about 50-79 contiguous residues in length, wherein the polypeptide binds to the extracellular domain (ECD) of HER-2 with an affinity binding constant of at least 10 8 M −1 , to provide a targeting therapeutic agent; and administering the targeting therapeutic agent to a subject having solid tumor tissue overexpressing HER-2.
    2. The method of claim 1 , wherein the isolated polypeptide is from about 69 to 79 contiguous residues in length.
    3. The method of claim 2 , wherein the isolated polypeptide comprises SEQ ID NO:1.
    4. The method of claim 3 , wherein the isolated polypeptide comprises the amino acid sequence of SEQ ID NO:2, or a fragment of SEQ ID NO:2 of about 80-419 contiguous residues in length, wherein the C-terminal 79 contiguous amino acids are present, wherein at least one N-linked glycosylation site is present, and wherein the polypeptide binds to the extracelluar domain (ECD) of HER-2 with an affinity binding constant of at least 10 8 M −1 .
    5. The method of claim 4 , wherein the isolated polypeptide is from about 350 to 419 contiguous residues in length and three N-linked glycosylation sites are present.
    6. The method of claim 5 , wherein the isolated polypeptide comprises SEQ ID NO:2.
    说明书
    [0001]1. Audio player 1.1 : Perspective 1.2 : Front 1.3 : Back 1.4 : Left 1.5 : Right 1.6 : Top 1.7 : Bottom The broken lines indicate portions of the article that form no part of the claimed design.
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