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    专

    可识别HCV E1E2蛋白的核酸适体、核酸适体的衍生物及其筛选方法和应用

    KR6245279B1
    发明人
    朱海珍, 方晓红, 刘斌, 徐丽, 杨大荣, 龙樱, 雷少华
    受让人
    湖南大学
    申请人
    Chih-Wei Chiang
    申请号
    080435
    申请日
    1989-03-22
    公开(公告)号
    KR6245279B1
    公开(公告)日
    2003-08-25
    IPC分类号
    B30B011/12
    CPC分类号
    -
    优先权号
    PA202070555
    优先权日
    2020-08-26
    摘要

    NOVELTY - The work-piece has a work-piece main body provided with a surface part (11). A recessed part (12) is indented from the surface part and provided with a side wall (13) that is inclined with respect to the surface part. The recessed part extends along the surface part. Width of a narrow part (15) is less than that of a wide part (14). Depth dimension of the side wall of the wide part is greater than that of the side wall of the narrow part. A bottom part (16) is arranged in center of the recessed part along width direction.

    USE - Work-piece i.e. golf club head. Can also be used as a golf club shaft and a tennis racket.

    ADVANTAGE - The depth dimension of the side wall of the wide part is greater than that of the side wall of the narrow part, so that uniform three-dimensional effect of the work-piece can be improved.

    DESCRIPTION OF DRAWING(S) - The drawing shows an enlarged view of a work-piece.

    Surface part (11)

    Recessed part (12)

    Side wall (13)

    Wide part (14)

    Narrow part (15)

    Bottom part (16)

    权利要求
    R p = ∏ i = 0 N R pi R pi = { 0 , if ⁢ ❘ "\[LeftBracketingBar]" c pi - c pib ❘ "\[RightBracketingBar]" ≤ Δ ⁢ c pti e α l ( c pl - c plb ) , else ⁢ i = 0 , … , N where N is an integer equal to or greater than one, R p is the reliability of the path in itself, α is an adjusted parameter, c pi is the path parameter of the path, c pib is the path parameter of the path generated one generation cycle before, ΔC pt is a threshold value of a rate of the path parameter; setting a weight for each of the plurality of paths based on the reliability of the path in itself; generating a single target path from among the generated plurality of paths based on the set weight of each of the plurality of paths; and outputting the single target path to a vehicle control device which outputs a target steering amount and controlling the vehicle according to the generated single target path from among the generated plurality of paths.
    2. The path generation device according to claim 1 , wherein the process of generating the path is the process of generating a plurality of paths sequentially over time, and the process of setting the reliability is the process of setting the reliability of each path in itself to be lower in a case where a variation in the path from a corresponding path generated before the path is greater than a first threshold value than in a case where the variation is smaller than the first threshold value.
    3. The path generation device according to claim 1 , wherein the set weight is smaller in a case where the reliability of the path in itself is lower than a second threshold value than in a case where the reliability of the path in itself is higher than the second threshold value.
    4. The path generation device according to claim 1 , wherein a lane for the path is estimated based on the environment measurement data, and the set weight is smaller in a case where the path deviates from the lane than in a case where the path does not deviate from the lane.
    5. The path generation device according to claim 1 , wherein the process of generating the target path is the process of generating the single target path by weighted averaging using the plurality of paths whose weights have been set.
    6. The path generation device according to claim 1 , wherein the first process further comprises: setting an evaluation function, using the plurality of paths whose weights have been set; setting predicted upper and lower limit values of a vehicle state quantity of the vehicle as constraints; setting the vehicle state quantity at a present moment as an initial value for optimization; and optimizing the evaluation function, using the constraints and the initial value as conditions for optimization.
    7. A vehicle control system comprising: the path generation device according to claim 6 ; and a vehicle control device, the vehicle control device including: one or more second processors configured to execute a second program; and one or more second memories configured to store the second program which, when the second program is executed by the one or more second processors, causes the one or more second processors to perform second processes including: calculating a target steering amount by which the vehicle is to travel along a target path indicated by the optimized evaluation function, using the optimized evaluation function and travel state data about a travel state of the vehicle.
    8. The vehicle control system according to claim 7 , wherein the process of calculating the target steering amount is the process of calculating the target steering amount, using the optimized evaluation function and a vehicle state quantity of the vehicle, the vehicle state quantity being estimated based on the travel state data.
    9. A vehicle control system comprising: the path generation device according to claim 1 ; and a vehicle control device, the vehicle control device including: one or more second processors configured to execute a second program; and one or more second memories configured to store the second program which, when the second program is executed by the one or more second processors, causes the one or more second processors to perform second processes including: calculating, using the single target path and travel state data about a travel state of the vehicle, a target steering amount by which the vehicle is to travel along the target path.
    10. A vehicle control system comprising: the path generation device according to claim 1 ; and a vehicle control device, the vehicle control device including: one or more second processors configured to execute a second program; and one or more second memories configured to store the second program which, when the second program is executed by the one or more second processors, causes the one or more second processors to perform second processes including: setting an evaluation function, using the plurality of paths whose weights have been set by the path generation device; setting predicted upper and lower limit values of a vehicle state quantity of the vehicle as constraints; setting the vehicle state quantity at a present moment as an initial value for optimization; and optimizing the evaluation function, using the constraints and the initial value as conditions for optimization, and calculating a target steering amount by which the vehicle is to travel along a target path indicated by the optimized evaluation function.
    11. The path generation device according to claim 1 , wherein only one of the generated plurality of paths has a non-zero value for the set weight so as to generate the generated single target path.
    12. The path generation device according to claim 1 , wherein the plurality of detectors have different detection modalities.
    13. The path generation device according to claim 1 , wherein said generating the single target path is based on the set weights of all of the generated paths, which are generated at the same time, the variation in the path falling within the predetermined range is a lane deviation, for said setting, for all generated paths of the plurality of paths generated at the same time, the reliability of each of the paths in itself, the reliability corresponds to the degree to which the variation in the path falls within the predetermined range.
    14. The path generation device according to claim 1 , wherein the single target path is set according to: y b =Σ i=0 N C wi x b i wherein C wi =(ω g ·C gi +ω c ·C ci +ω r ·C ri )/ω w where N is an integer equal to or greater than one, y b is a target path indicated by an N-th degree polynomial, ω g is a weight output from a first detector, @ is a weight output from a second detector, ω r is a weight output from a third detector, C g is a parameter of an N-th degree polynomial output from the first detector as a path, C c is a parameter of an N-th degree polynomial output from the second detector as a path, C r is a parameter of an N-th degree polynomial output from the third detector as a path.
    R p = ∏ i = 0 N R pi R pi = { 0 , if ⁢ ❘ "\[LeftBracketingBar]" c pi - c pib ❘ "\[RightBracketingBar]" ≤ Δ ⁢ c pti e α l ( c pl - c plb ) , else ⁢ i = 0 , … , N where N is an integer equal to or greater than one, R p is the reliability of the path in itself, a is an adjusted parameter, c pi is the path parameter of the path, c pib is the path parameter of the path generated one generation cycle before, Δc pt is a threshold value of a rate of the path parameter; setting a weight for each of the plurality of paths based on the reliability of the path in itself; generating a single target path from among the generated plurality of paths based on the set weight of each of the plurality of paths; and outputting the single target path to a vehicle control device which outputs a target steering amount and controlling the vehicle according to the generated single target path from among the generated plurality of paths.
    16. The vehicle control system according to claim 15 , wherein the process of calculating the target steering amount is the process of calculating the target steering amount using a vehicle state quantity of the vehicle in the single target path, the vehicle state quantity being estimated based on a curvature of the target path, an amount of lateral deviation, an amount of angular deviation, and the travel state data at a forward look ahead point that is set forward of the vehicle.
    17. The vehicle control system according to claim 15 , wherein only one of the generated plurality of paths has a non-zero value for the set weight so as to generate the generated single target path.
    18. The vehicle control system according to claim 15 , wherein the plurality of detectors have different detection modalities.
    说明书
    [0001]Technical Field The invention relates to a technical field of operation of the mechanical arm, in particular to a novel minimally invasive surgery mechanical arm sleeve. Background Art As medical technology of the progressive development of mature, people used in the life, work in the physical harm also possible to obtain a better treatment. Minimally invasive surgery appeared, minimally invasive surgery, as the name implies is minor trauma of surgery. And the use of a laparoscope, thoracoscope and other modern medical and related equipment of operation. In a short period of twenty years of development in, minimally invasive surgery has become a modern medical an essential operation mode. The prior minimally invasive surgery, following shortcomings: 1. with surgical wound large, heal slowly, not enough fullyenclosed; 2. on the market at present operation mechanical arm sleeve are both rigid mechanical arm sleeve, not at any position, limits the conduct of minimally invasive surgery, and its movement single form; 3. the current more generic invasive surgical robot system in the sleeve, its price is expensive, and complex operation, fails to satisfy the present demand. Content of the invention In view of the above disadvantages of the prior art, the purpose of this invention is to provide a novel minimally invasive surgery mechanical arm sleeve, the minimally invasive operation mechanical arm sleeve and the operation is simple, novel design, small volume, light weight, can make the endoscope has a broader perspective, and is easy to carry out. Novel design, small volume, light weight, and is easy to carry out. To achieve the above object, the present invention is realized through the following technical solution. A minimally invasive operation mechanical arm sleeve, mounted on the arm for minimally invasive surgery, including extends into the sleeve, and a movable sleeve arranged in the casing; wherein: The extends into the sleeve through-hole, extends into the sleeve through the through hole movably mounted in the front end of the mechanical arm of minimally invasive surgery, for minimal invasive surgery of the mechanical arm is elastic shaft transmission and minimally invasive surgery of the mechanical arm endoscope data transmission line; The movable sleeve arm that is used for fixing the minimally invasive surgery, which comprises a plurality of reverse double-spiral of the universal joint, and through the reverse double-spiral of the universal joint and connected into the sleeve, the sleeve can be rotated into; The endoscope sleeve mounted on the movable sleeve, adopts the parallelogram support structure, for mounting of the endoscope of the minimally invasive surgical operation arm; wherein: the endoscope sleeve through a reverse double-spiral of the universal joint to realize the backward movement of the endoscope, the endoscope sleeve through the parallelogram support structure to move up and down of the endoscope, the endoscope has better vision. Preferably, the reverse double-spiral of the universal joint, including the line drives steel wire and the joint mechanism; wherein: The joint mechanism includes a fixing mechanism and at least three parallel joint monomers, wherein each monomer of a joint at one end of the screwed with the fixing mechanism, each monomer of a joint and another end extending into the sleeve screwed; Each of the monomer with a joint and one end of the screwed fixing mechanism are connected with a steel wire the line drives; when one the line drives steel wire rotates, drives one single rotation of the joint, because the joint is screwed with the fixing mechanism between the monomer, monomer relative to the fixing mechanism at this moment mobile, the remaining joint monomer keeps still, realize the joint mechanism of the angle of rotation; The endoscope sleeve rotatably mounted on the fixing mechanism. Preferably, each said joint of monomer comprising: connecting arm 1st, 2nd and arm of the nodes of the cube, the cube node is provided with threaded holes, said 1st and 2nd connecting arm connecting with the cube node hinged through the threaded hole. Preferably, the connecting arm of the 1st and 2nd are respectively arranged at the end of the threaded part, and through the threaded part are respectively connected with the fixing mechanism and extends into the sleeve connection, wherein: 1st is connected with the end of the arm threaded part is left-hand thread, and correspondingly, 2nd terminal of the connecting arm of the threaded part is right-hand thread; or 1st is connected with the end of the arm threaded part is right-hand thread, and correspondingly, 2nd terminal of the connecting arm of the threaded part is left-hand thread. Preferably, the fixing mechanism is cylinder table structure, cylindrical table is provided with a plurality of threaded hole, the end of the arm is connected to the 1st or 2nd threaded part connected to the end of the arm threaded part engaged with the threaded hole. Preferably, the fixing mechanism adopts the special stainless steel material, in particular to the aluminum alloy. Preferably, the steel wire states the line to drive special steel wire, in particular to having a large torsional rigidity characteristics of the steel wire. Preferably, the joint mechanism made of aluminum alloy. Preferably, the extends into the sleeve, the sleeve of the movable sleeve and the endoscope adopts the special stainless steel material, in particular to the aluminum alloy. With the prior technology than the first, this invention has the following effects: 1. the present invention provides a minimally invasive operation mechanical arm sleeve, the operation is simple, novel design, small volume, light weight, can make the endoscope has a broader perspective, and is easy to carry out. Novel design, small volume, light weight, and is easy to carry out. 2. the invention is convenient to use, and production cost is cheap, making full use of the reverse double-spiral the universal joint with the operability. 3. reverse double-spiral of the universal joint body material is preferably aluminum alloy, aluminum alloy in the course of using corrosion-resistant, can be effectively ensures the product use time, and aluminum alloy density is small, light weight, as a novel minimally invasive surgery mechanical arm sleeve when in use, will not be a burden to the body. 4. the invention convenient disassembly, when a sleeve is damaged, can be easily remove replaced with a new sleeve, the application effect is not affected. 5. the invention effectively overcomes the postoperative wound in the prior art large, heal slowly, not at any position, limits the conduct of minimally invasive surgery, complex operation, unable to realize the operation wound is less and the like, has high industrial value. Description of drawings By reading in the light of the following with photos to the non-restrictive embodiment of the detailed description, other features of the present invention, objectives and advantages will become more obvious: Figure 1 is the partial structure diagram of the present invention minimally invasive surgery mechanical arm sleeve; Figure 2 is the schematic view of the overall structure of the present invention minimally invasive surgery mechanical arm sleeve. In the drawings: 1 is arranged in the casing 2 for fixing mechanism 3 is a movable sleeve 4 mechanical arm sleeve for minimally invasive surgery 5 is a joint monomer 6 extend into a sleeve Mode of execution Below and put to the embodiment of the invention detailed description of: the embodiment in a technical solution of this invention under the premise of implementation, provides detailed embodiment and specific operation process. It should be noted that, of the field for the ordinary technical personnel, in not break away from the the present invention contemplates the premise, can also make a number of deformation and improve, these belong to the scope of protection of the present invention. Embodiment This embodiment provides a minimally invasive operation mechanical arm sleeve, mounted on the arm for minimally invasive surgery, including extends into the sleeve, and a movable sleeve arranged in the casing; wherein: The extends into the sleeve through-hole, extends into the sleeve through the through hole movably mounted in the front end of the mechanical arm of minimally invasive surgery, for minimal invasive surgery of the mechanical arm is elastic shaft transmission and minimally invasive surgery of the mechanical arm endoscope data transmission line; The movable sleeve arm that is used for fixing the minimally invasive surgery, which comprises a plurality of reverse double-spiral of the universal joint, and through the reverse double-spiral of the universal joint and connected into the sleeve, the sleeve can be rotated into; The endoscope sleeve mounted on the movable sleeve, adopts the parallelogram support structure, for mounting of the endoscope of the minimally invasive surgical operation arm; wherein: the endoscope sleeve through a reverse double-spiral of the universal joint to realize the backward movement of the endoscope, the endoscope sleeve through the parallelogram support structure to move up and down of the endoscope, the endoscope has better vision. Further, the reverse double-spiral of the universal joint, including the line drives steel wire and the joint mechanism; wherein: The joint mechanism includes a fixing mechanism and at least three parallel joint monomers, wherein each monomer of a joint at one end of the screwed with the fixing mechanism, each monomer of a joint and another end extending into the sleeve screwed; Each of the monomer with a joint and one end of the screwed fixing mechanism are connected with a steel wire the line drives; when one the line drives steel wire rotates, drives one single rotation of the joint, because the joint is screwed with the fixing mechanism between the monomer, monomer relative to the fixing mechanism at this moment mobile, the remaining joint monomer keeps still, realize the joint mechanism of the angle of rotation; The endoscope sleeve rotatably mounted on the fixing mechanism. Further, each of the joint monomer include: connecting arm 1st, 2nd and arm of the nodes of the cube, the cube node is provided with threaded holes, said 1st and 2nd connecting arm connecting with the cube node hinged through the threaded hole. Further, the connecting arm of the 1st and 2nd are respectively arranged at the end of the threaded part, and through the threaded part are respectively connected with the fixing mechanism and extends into the sleeve connection, wherein: 1st is connected with the end of the arm threaded part is left-hand thread, and correspondingly, 2nd terminal of the connecting arm of the threaded part is right-hand thread; or 1st is connected with the end of the arm threaded part is right-hand thread, and correspondingly, 2nd terminal of the connecting arm of the threaded part is left-hand thread. Further, the fixing mechanism is cylinder table structure, cylindrical table is provided with a plurality of threaded hole, the end of the arm is connected to the 1st or 2nd threaded part connected to the end of the arm threaded part engaged with the threaded hole. Further, the fixing mechanism adopts the special stainless steel material, in particular to the aluminum alloy. Further, the steel wire states the line to drive special steel wire, in particular to having a large torsional rigidity characteristics of the steel wire. Further, the joint mechanism made of aluminum alloy. Further, the extends into the sleeve, the sleeve of the movable sleeve and the endoscope adopts the special stainless steel material, in particular to the aluminum alloy. The Figure below further described in this embodiment. Please refer to fig. 1 to fig. 2. Figure 1 is the partial structure diagram of the present invention minimally invasive surgery mechanical arm sleeve, including extends into the sleeve, the movable sleeve, in the casing. Wherein the opening extends into the sleeve in the elastic shaft transmission and can be used for the endoscope data transmission; the movable sleeve can be fixed micro-invasive operation arm, the movable sleeve by the 3 reverse double-spiral of the universal joint and connected into the sleeve, so that it can rotate, said mechanism comprises a threaded hole of a column table is arranged in the middle, the fixing mechanism with the reverse double-spiral of the universal joint is engaged, the reverse double-spiral of the universal joint through control the line drives; endoscope sleeve through the parallelogram support structure to control the movement of the endoscope, make it has better vision. The operation is simple, novel design, small volume, light weight, and is easy to carry out. Minimally invasive surgery of the mechanical arm sleeve since all the components of aluminum or stainless steel, the density is small, light weight, to the operating system by gravity requirements of small, convenient and is not easy to corrode. In the operation, as long as the through high temperature sterilization can use, safety and sanitation. The material used in the process of in use, not easy to be damaged. Figure 1 is the structure diagram of the minimally invasive operation mechanical arm sleeve local schematic view of the mechanism, Figure 2 is a novel minimally invasive surgery mechanical arm sleeve, extends into the sleeve can make the structure integral front and back movement, reverse double-spiral of the universal joint can move back and forth in the casing, and the parallelogram support structure but the endoscope to move up and down, thus the maximum is the increase of the angle of the endoscope. Which is very convenient for doctors to minimally invasive surgery. The embodiment of the invention: Extends into the sleeve 6 can be provided with a through hole in the elastic shaft transmission and endoscope data transmission; the movable sleeve 3 can be fixed micro-invasive operation arm, the movable sleeve 3 is composed of a reverse double-spiral of the universal joint and extends into the sleeve 6 connected, cause it to rotate, the fixing mechanism is arranged in the middle of the threaded hole of the cylindrical platform, the fixing mechanism is engaged with the joint monomer, the reverse double-spiral of the universal joint through control the line drives; endoscope sleeve through the parallelogram support structure to control the movement of the endoscope, make it has better vision With the threaded hole of the plate to the cylinder of the special stainless steel. The endoscope bushing adopts the parallelogram support structure. The movable sleeve 3 can be fixed micro-invasive operation arm. Minimally invasive surgery mechanical arm sleeve adopts the special stainless steel. Extends into the sleeve 6 can be used for the elastic shaft transmission and endoscope data transmission. Endoscope can move back and forth through the extends into the sleeve. The endoscope can be through a reverse double-spiral of the universal joint to move back and forth. This embodiment provides a novel minimally invasive surgery mechanical arm sleeve is simple in structure, easy to use, low production cost, make full use of the design of the ingenious. Main body of the device material is preferably aluminum alloy, aluminum alloy in the course of using corrosion-resistant, can be effectively ensures the product use time, and aluminum alloy density is small, light weight, as a novel minimally invasive surgery mechanical arm sleeve when in use, will not be a burden to the body. This embodiment is convenient to disassemble, when a sleeve is damaged, can be easily remove replaced with a new sleeve, the application effect is not affected; in addition, the minimally invasive operation provided by the embodiment of the mechanical arm sleeve smart structure, the operation is simple, and the production cost is low, therefore, the embodiment effectively overcomes the shortcomings in the prior art and has high industrial value in use. The above specific embodiment of the present invention are described. One needs to understand is, the invention is not limited to the above specific embodiment, technical personnel in the field can be in the scope of the claims in various deformation or modification made, this does not affect the substance of the present invention.
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