专

壳聚糖-Pickering乳液白细胞介素12佐剂体系的制备方法及其应用

188200200232W

发明人

李忠玉, 舒明艺, 赵兰华, 文雅婷

受让人

UNIV SOUTH CHINA

申请人

Custom Molded Products Inc.

申请号

007823

申请日

1998-04-16

公开(公告)号

188200200232W

公开(公告)日

1970-07-08

IPC分类号

H04Q007/34H04M003/22H04B017/00H04B007/26H04M001/24H04M003/26G06F003/00

CPC分类号

优先权号

11005017

优先权日

2022-01-29

摘要

The pipe (2) is connected to the terminals of a first feedwater pipework (1a), a second feedwater pipework (1b) and third feedwater pipework (1c) forming a Y-shape state. The inner periphery of the pipe consists of several spiral shape grooves (4) which reduce the speed of the supplied water from the feedwater pump.

ADVANTAGE -Effectively controls generation of turbulent flow due to formation of several spiral shape grooves, thus prevents erosion in periphery of connecting pipe.

权利要求

1 . A method for monitoring treatment of a particular patient, the method comprising: collecting patient treatment data associated with a plurality of respiratory therapies used by the particular patient, wherein the plurality of respiratory therapies includes at least two of ventilation therapy, oxygen therapy, cough-assistance therapy, suction therapy, and nebulization therapy; and transmitting the collected patient treatment data to a server, wherein the server includes a patient data module storing data associated with a plurality of individual patients.

2 . The method of claim 1 wherein collecting the patient treatment data includes receiving the patient treatment data at a data transfer element, and wherein transmitting the collected patient treatment data includes transmitting the patient treatment data from the data transfer element to the server.

3 . The method of claim 2 wherein the data transfer element is coupled to a plurality of medical devices, and wherein receiving the patient treatment data at the data transfer element includes receiving patient treatment data associated with the plurality of medical devices.

4 . The method of claim 3 wherein the plurality of medical devices includes: at least one respiratory device configured to provide the plurality of respiratory therapies; and at least one additional medical device, wherein the at least one additional medical device includes a blood pressure monitor, a blood glucose monitor, a heart rate monitor, an SpO 2 monitor, a weight monitor, a carbon dioxide monitor, and/or a drug delivery device, wherein the patient treatment data includes (i) first patient treatment data associated with the plurality of respiratory therapies and the at least one respiratory device, and (ii) second patient treatment data associated with the at least one additional medical device.

5 . The method of claim 1 wherein collecting patient treatment data associated with the plurality of respiratory therapies includes collecting the patient treatment data from a single respiratory device configured to deliver the plurality of respiratory therapies to the particular patient.

6 . The method of claim 1 wherein collecting patient treatment data associated with the plurality of respiratory therapies includes collecting the patient treatment data from at least two respiratory devices configured to deliver the plurality of respiratory therapies to the particular patient.

7 . The method of claim 1 wherein collecting patient treatment data includes collecting ventilation therapy data including at least one of a pressure waveform, a flow waveform, or a volume waveform.

8 . The method of claim 1 wherein transmitting the collected patient treatment data to the server includes automatically and periodically transmitting the collected patient treatment data to the server.

9 . The method of claim 1 wherein transmitting the collected patient treatment data to the server includes transmitting the collected patient treatment data to the server in response to a user selection to transmit the collected patient treatment data to the server.

10 . The method of claim 1 wherein transmitting the collected patient treatment data to the server includes continuously transmitting the collected patient treatment data to the server.

11 . The method of claim 1 wherein the operations of collecting and transmitting are performed in substantially real-time.

12 . The method of claim 1 , further comprising generating a patient therapy report, wherein the patient therapy report includes a graphical display of at least some of the patient treatment data transmitted to the server.

13 . The method of claim 12 , further comprising displaying, via a digital display, the patient therapy report.

14 . The method of claim 13 wherein the displayed patient therapy report is interactive.

15 . The method of claim 13 wherein the displayed patient therapy report is customized based on a user's preferences.

16 . The method of claim 13 , further comprising: receiving, from a user, one or more annotations or markings to be added to the report; and in response to receiving the one or more annotations or markings, adding the one or more annotations or markings to the report.

17 . The method of claim 1 wherein the plurality of respiratory therapies includes ventilation therapy, oxygen therapy, and cough-assistance therapy.

18 . The method of claim 1 , further comprising analyzing the collected patient data and, based on the analysis, providing one or more recommendations associated with at least one of the plurality of therapies.

19 . The method of claim 18 wherein analyzing the collected patient data includes using a trained machine learning model to identify the one or more recommendations associated with the at least one of the plurality of therapies.

20 . The method of claim 1 wherein the patient treatment data is first patient treatment data, the method further comprising: collecting second patient treatment data associated with a plurality of non-respiratory therapies used by the particular patient; transmitting the collected second patient treatment data to the server; and generating a patient report including at least a subset of the first patient treatment data and a subset of the second patient treatment data.

21 . A computer-implemented method for generating a patient therapy report displaying patient treatment data associated with a particular patient, the method comprising: receiving a request to generate the patient therapy report, wherein the request includes a patient identifier associated with the particular patient; in response to receiving the request, using the patient identifier to identify patient treatment data associated with the particular patient, wherein the patient treatment data associated with the particular patient is stored on a server storing patient treatment data associated with a plurality of individual patients including the particular patient, and wherein the patient treatment data associated with the particular patient includes therapy data associated with a plurality of respiratory therapies used by the particular patient; generating a patient therapy report, wherein the patient therapy report includes a graphical display of at least some of the patient treatment data associated with the particular patient; and transmitting the patient therapy report to a device configured to display the patient therapy report.

22 . The method of claim 21 wherein the plurality of respiratory therapies includes ventilation therapy, oxygen therapy, cough-assistance therapy, suction therapy, and nebulization therapy.

23 . The method of claim 21 wherein the patient treatment data includes usage data associated with the plurality of the respiratory therapies.

24 . The method of claim 21 wherein the patient therapy report is a customized patient therapy report, and wherein receiving the request to generate the patient therapy report includes receiving a user selection specifying at least one parameter to be included in the patient therapy report.

25 . The method of claim 21 wherein the patient identifier is a unique alpha-numeric code associated with the patient.

26 . A system including a non-transitory computer readable medium storing instructions that, when executed, cause the system to perform the operations of: collecting patient treatment data associated with a plurality of respiratory therapies used by a particular patient, wherein the plurality of respiratory therapies includes at least two of ventilation therapy, oxygen therapy, cough-assistance therapy, suction therapy, and nebulization therapy; and transmitting the collected patient treatment data to a server, wherein the server includes a patient data module storing patient treatment data for a plurality of individual patients including the particular patient.

27 . The system of claim 26 wherein the system includes a data transfer element, and wherein the operation of collecting the patient treatment data includes receiving the patient treatment data at the data transfer element, and wherein the operation of transmitting the collected patient treatment data includes transmitting the patient treatment data from the data transfer element to the server.

28 . The system of claim 27 wherein the data transfer element is couplable to a plurality of medical devices, and wherein the operation of receiving the patient treatment data at the data transfer element includes receiving patient treatment data associated with the plurality of medical devices.

29 . The system of claim 28 wherein the plurality of medical devices includes: at least one respiratory device configured to provide the plurality of respiratory therapies; and at least one additional medical device, wherein the at least one additional medical device includes a blood pressure monitor, a blood glucose monitor, a hear rate monitor, an SpO 2 monitor, a weight monitor, a carbon dioxide monitor, and/or a drug delivery device, wherein the patient treatment data includes (i) first patient treatment data associated with the plurality of respiratory therapies and the at least one respiratory device, and (ii) second patient treatment data associated with the at least one additional medical device.

30 . The system of claim 26 wherein the operation of collecting patient treatment data associated with the plurality of respiratory therapies includes collecting the patient treatment data from a single respiratory device configured to deliver the plurality of respiratory therapies to the particular patient.

31 . The system of claim 26 wherein the operation of collecting patient treatment data associated with the plurality of respiratory therapies includes collecting the patient treatment data from at least two respiratory devices configured to deliver the plurality of respiratory therapies to the particular patient.

32 . The system of claim 26 wherein the operation of transmitting the collected patient treatment data to the server includes automatically and periodically transmitting the collected patient treatment data to the server.

33 . The system of claim 26 wherein the operation of transmitting the collected patient treatment data to the server includes transmitting the collected patient treatment data to the server in response to a user selection to transmit the collected patient treatment data to the server.

34 . The system of claim 26 wherein the operation of transmitting the collected patient treatment data to the server includes continuously transmitting the collected patient treatment data to the server.

35 . The system of claim 26 wherein the instructions, when executed, further cause the operation of generating a patient therapy report, wherein the patient therapy report includes a graphical display of at least some of the patient treatment data transmitted to the server.

36 . The system of claim 35 wherein the instructions, when executed, further cause the operation of displaying, via a digital display, the patient therapy report.

37 . The system of claim 36 wherein the displayed patient therapy report is interactive.

38 . The system of claim 36 wherein the displayed patient therapy report is customized based on a user's preferences.

39 . The system of claim 26 wherein the plurality of respiratory therapies includes ventilation therapy, oxygen therapy, and cough-assistance therapy.

40 . The system of claim 26 wherein the instructions, when executed, further cause the operation of analyzing the collected patient data and, based on the analysis, providing one or more recommendations associated with at least one of the plurality of therapies.

41 . The system of claim 40 wherein the operation of analyzing the collected patient data includes using a trained machine learning model to identify the one or more recommendations associated with the at least one of the plurality of therapies.

42 . A method for monitoring treatment of a particular patient, the method comprising: collecting first patient treatment data associated with a first medical device used by the particular patient; collecting second patient treatment data associated with a second medical device used by the patient; transmitting the collected first and second patient treatment data to a server, wherein the server includes a patient data module storing data associated with a plurality of individual patients including the particular patient; and generating a report including the first patient treatment data and the second patient treatment data.

43 . The method of claim 42 wherein: the first medical device is a respiratory device that provides at least one of ventilation therapy, oxygen therapy, cough-assistance therapy, suction therapy, or nebulization therapy; and the second medical device is a blood pressure monitor, a blood glucose monitor, a heart rate monitor, an SpO 2 monitor, a weight monitor, a carbon dioxide monitor, and/or a drug delivery device.

44 . The method of claim 42 wherein the first patient treatment data is associated with a respiratory therapy and the second patient treatment data is associated with a non-respiratory therapy.

说明书

[0001]RELATED APPLICATIONS

[0002]This application is related to U.S. patent application Ser. No. 11/530,054, titled “Nanocrystal Non-Volatile Memory Cell and Method Therefor,” assigned to the assignee hereof and filed even date herewith

[0003]FIELD OF THE INVENTION

[0004]The invention relates to integrated circuits and, more particularly, to integrated circuit memories that have memory cells with nanocrystals.

[0005]BACKGROUND OF THE INVENTION

[0006]The use of nanocrystals in non-volatile memories (NVMs) was primarily to have redundancy in each memory cell so that if there were a weak spot in a dielectric layer around the storage layer causing leakage of charge, then only a single nanocrystal in the storage layer would be adversely impacted and the remaining nanocrystals would still retain charge. There are typically difficulties with limited memory window, threshold voltage shift during program/erase cycling endurance, and read disturb of bits in a programmed state that are greater for nanocrystal NVM cells than for floating gate memory cells. The limited memory window arises from coulomb blockade effects that limit the charge storage capacity of the nanocrystals so that the total charge stored is less resulting in less threshold voltage differential between the logic high and logic low states. The program/erase cycling results in charge trapping, which can be cumulative, in the dielectric above the nanocrystals and thus reducing endurance. In the case of the floating gate, the charge is prevented from reaching the dielectric overlying the floating gate by the floating gate itself. Read disturb in bits that are in a programmed state arises due to the relatively higher field above the nanocrystals compared to the electric field above the floating gate in a floating gate device.

[0007]Thus, there is a need for NVM memory cells having nanocrystals overcoming or at least reducing these difficulties.

[0008]BRIEF DESCRIPTION OF THE DRAWINGS The foregoing and further and more specific objects and advantages of the invention will become readily apparent to those skilled in the art from the following detailed description of a preferred embodiment thereof taken in conjunction with the following drawings: FIG. 1 is a cross section of a semiconductor device structure at a stage in processing according to a first embodiment of the invention; FIG. 2 is a cross section of the semiconductor device structure of FIG. 1 at a subsequent stage in processing to that shown in FIG. 1 ; FIG. 3 is a cross section of the semiconductor device structure of FIG. 2 at a subsequent stage in processing to that shown in FIG. 2 ; FIG. 4 is a cross section of the semiconductor device structure of FIG. 3 at a subsequent stage in processing to that shown in FIG. 3 ; FIG. 5 is a cross section of the semiconductor device structure of FIG. 4 at a subsequent stage in processing to that shown in FIG. 4 ; FIG. 6 is a cross section of a semiconductor device structure at a stage in processing according to a second embodiment of the invention; FIG. 7 is a cross section of the semiconductor device structure of FIG. 6 at a subsequent stage in processing to that shown in FIG. 6 ; FIG. 8 is a cross section of the semiconductor device structure of FIG. 7 at a subsequent stage in processing to that shown in FIG. 7 ; FIG. 9 is a cross section of the semiconductor device structure of FIG. 8 at a subsequent stage in processing to that shown in FIG. 8 ; and FIG. 10 is a cross section of the semiconductor device structure of FIG. 9 at a subsequent stage in processing to that shown in FIG. 9 ;

[0009]DETAILED DESCRIPTION OF THE INVENTION

[0010]In one aspect a memory device has nanocrystals that are substantially all much larger than nanocrystals typically used in memory cells. The oversized nanocrystals establish a contour that the overlying dielectric follows on its surface. The result is that the subsequent overlying gate has this contour as well because the gate wraps around the nanocrystals to some extent. This has the effect of providing better capacitive coupling between the gate and the nanocrystals which results in lower electric field in the dielectric overlying the nanocrystals. The reduced electric field has the effect of improving endurance, memory window, and read disturb. This is better understood by reference to the drawings and the following description.

[0011]Shown in FIG. 1 is a semiconductor device structure 10 comprising a semiconductor layer 12 , a gate dielectric layer 14 on semiconductor layer 12 , and a plurality of nanocrystals 16 on gate dielectric 14 . Nanocrystal 18 is one of plurality 16 and is exemplary of nanocrystals 16 . Semiconductor layer 12 may be part of a semiconductor-on-insulator (SOI) or bulk substrate. Semiconductor layer 12 is preferably silicon but could be another semiconductor material. Gate dielectric 14 is preferably thermally grown silicon oxide but could be another gate dielectric material. Nanocrystals 16 , which function as storage elements, are preferably about 25 nanometers in diameter which is about 5 times more than is typically used for NVM memories using nanocrystals. They can be lower or higher diameter though but should be at least 12 nanometers in diameter. Nanocrystals 16 are preferably made using a CVD process using a silicon based precursor but another process may also be effective.

[0012]CVD silicon-based processes are known to be able to achieve the relatively large diameters. One such process uses silane as the precursor at a temperature range of 500-550 degrees Celsius at a partial pressure 700-800 millitorr for about 500 seconds. Additionally, nitrogen is co-flowed with the silane to obtain a total pressure of about 18 torr. Another process uses disilane as the precursor at a temperature range of 450-500 degrees Celsius, at a partial pressure at 80-100 millitorr, for about 300 seconds. Similar for this process, nitrogen is co-flowed with the disilane to obtain a total pressure of about 18 torr. In both processes, an anneal at 750 degrees Celsius in nitrogen is performed for 10 seconds. These processes do result in some variation, even more than two to one in some cases, in diameter across a wafer. What can occur is that two growing nanocrystals can come in contact and coalesce into a larger size nanocrystal. For the example shown, none of the nanocrystals exhibit this coalescing of two nanocrystals. Yet another silicon-precursor process that is more complex but that provides good uniformity and controllable spacing is described in U.S. patent application Ser. No. 11/065,579 and is incorporated herein by reference.

[0013]Shown in FIG. 2 is semiconductor device structure 10 after formation of a nitrided oxide layer 20 around plurality 16 of nanocrystals. This is achieved using a thermal oxide process similar to that used for forming gate dielectrics that are very thin, such as 20 Angstroms or less.

[0014]Shown in FIG. 3 is semiconductor device structure 10 after forming control dielectric 22 of high temperature oxide (HTO). HTO is typical for the oxide over the nanocrystals. The thickness of the HTO around nanocrystals 16 is preferably no more than 80 per cent of the diameter of nanocrystals 16 . For the case that nanocrystals 16 are chosen to be 250 Angstroms in diameter, the preferred thickness of control dielectric 22 is 80 Angstroms. In such case, the thickness is only about 32 per cent of the diameter of nanocrystals 16 . Nanocrystals 16 are preferably spaced apart by a distance greater than the thickness of control dielectric 22 but less than twice the thickness of control dielectric 22 . In this example, the spacing that fits half way between these two requirements is about 120 Angstroms. As shown, control dielectric 22 has a top surface that follows the contour of the round top portions of nanocrystals 16 .

[0015]Shown in FIG. 4 is semiconductor device structure 10 after depositing a gate material 24 over control dielectric 22 . Gate material 24 is preferably polysilicon but could another material such as one of the metals being considered for use as a gate for MOS transistors. The effect is that gate material 24 is in proximity to the top surface of nanocrystals 16 according to the top surface of control dielectric 22 which in turn follows the contour of the top portions of nanocrystals 16 .

[0016]Shown in FIG. 5 is semiconductor device structure 10 after performing conventional process steps for forming a transistor memory cell after the gate material has been deposited over the nanocrystals. In FIG. 5 , semiconductor device structure 10 shows an etched gate material 24 to form a gate, a sidewall spacer 26 around the gate, remaining nanocrystals 16 that are under the gate, and source/drains 28 and 30 on opposite sides of the gate and in semiconductor layer 12 .

[0017]The resulting memory cell shown in FIG. 5 provides better coupling between the gate and nanocrystals 16 due to the top surface of control dielectric 22 following the contour of the top portions of nanocrystals 16 . With improved coupling between the gate and nanocrystals 16 there is less voltage drop between the gate and nanocrystals 16 for a given gate voltage. This results in lower electrical field in the control dielectric 22 during operation of the device. The reduced electric field mitigates electron tunneling from the gate into nanocrystals during erase and electron tunneling from nanocrystals to gate during programming or READ. As a result improved memory window is obtained through better erase and programming, reduced read disturb, and improved endurance. Further, the lower electric field also results in less acceleration of electrons injected during programming but not captured by nanocrystals. The reduced acceleration of these electrons in the control dielectric reduces charge trapping in the control dielectric and improves program-erase cycling endurance of the memory device.

[0018]Shown in FIG. 6 is a semiconductor device structure 50 comprising a semiconductor substrate 52 , a gate dielectric layer 54 on semiconductor substrate 52 , and a nitrided layer 56 formed at the surface of gate dielectric layer 54 , and a plurality of nanocrystals 58 formed on nitrided layer 56 . Nanocrystal 60 is one of plurality 58 and is exemplary of nanocrystals 58 . Semiconductor layer 52 may be part of a semiconductor-on-insulator (SOI) or bulk substrate. Semiconductor layer 52 is preferably silicon but could be another semiconductor material. Gate dielectric 54 is preferably thermally grown silicon oxide but could be another gate dielectric material. Nanocrystals 58 are preferably hemispherically shaped and about 25 nanometers in diameter which is about 5 times more than is typically used for NVM memories using nanocrystals. They can be lower or higher diameter though but should be at least 12 nanometers in diameter. Nanocrystals 58 are made in substantially the same way as nanocrystals 16 of FIGS. 1-5 , but are hemispherical due to being formed on nitrided layer 56 instead of on an oxide layer such as gate dielectric layer 14 of FIGS. 1-5 . In this case nanocrystals 58 are spaced further apart, preferably about 25 nanometers apart. This is achieved in the described silane and disilane processes by increasing the temperature of deposition. For example, in the silane process, the temperature is increased to 600 to 650 Celsius. For the disilane process, the temperature is increased to 550 to 600 degrees Celsius. Nitrided layer 56 is formed by exposing gate dielectric layer 54 to decoupled plasma nitridation. Nitrided layer 56 is preferably about 10 Angstroms in thickness. Gate dielectric layer 54 has a thickness of preferably about 50 Angstroms.

[0019]Shown in FIG. 7 is semiconductor device structure 50 after thermally growing a nitrided oxide layer 62 of about 5 to 10 nanometers in thickness. One way this can be achieved is by exposing nanocrystals 58 to nitric oxide (NO) at a relatively high temperature such as about 850 degrees Celsius.

[0020]Shown in FIG. 8 is semiconductor device structure 50 after deposition of a control dielectric layer 64 on nitrided oxide layers of nanocrystals 58 and on nitrided layer 56 that is exposed in spaces between the various nanocrystals 58 . This may be an optional layer because nitrided oxide layers 62 provide a dielectric that functions as a control dielectric for nanocrystals 58 .

[0021]Shown in FIG. 9 is semiconductor device structure 50 after depositing a layer of gate material 66 over nanocrystals 58 . Gate material is preferably polysilicon but could be another material such as a metal being considered as a gate for MOS transistors.

[0022]Shown in FIG. 10 is semiconductor device structure 50 after performing conventional process steps for forming a transistor memory cell after the gate material has been deposited over the nanocrystals similar as for semiconductor device 10 of FIG. 5 . In FIG. 10 , semiconductor device structure 50 shows an etched gate material 66 to form a gate, a sidewall spacer 68 around the gate, remaining nanocrystals 58 that are under the gate, and source/drains 70 and 72 on opposite sides of the gate and in semiconductor layer 52 . The result is that there is a substantial portion of the gate between pairs of nanocrystals 58 , pairs being ones that are adjacent.

[0023]The resulting memory cell shown in FIG. 10 , similar to that shown in FIG. 5 , provides better capacitive coupling than is typical for nanocrystal NVMs between the gate and nanocrystals 58 due to the top surface of control dielectric 22 following the whole contour of the portion of the nanocrystals 16 above nitrided layer 56 . The gate has a substantial portion that is between adjacent nanocrystals. With improved capacitive coupling between the gate and nanocrystals 16 there is less voltage drop between the gate and nanocrystals 16 for a given gate voltage. The result of this reduced voltage drop is improved memory window through better erase and better programming, reduced read disturb, and improved program-erase cycling endurance.

[0024]In this example, the control dielectric layer 64 is optional if the nitrided oxide layer 62 on nanocrystals 58 is sufficient to withstand the voltage applied to the gate for programming and erase for nanocrystals 58 and also that gate dielectric 54 and nitrided layer 56 are sufficient to withstand the voltage applied to the gate for programming and erase. As a further alternative, nitrided layer 56 may be omitted. In such case, the exposed spaces between nanocrystals 58 will grow some nitrided oxide during the application of the nitric oxide that causes the growth of nitrided oxide layer 62 on nanocrystals 58 . This would have the effect of reducing the need for adding control dielectric 64 . In such case nanocrystals would be spherical because they would have been formed on an oxide layer. This is somewhat disadvantageous because a portion of the gate would be below the center point of the sphere and thus cause a partial bias against the desired direction of electron movement during program and erase. The adverse bias would be small and may be worth the benefit of the increase in gate dielectric thickness.

[0025]Various other changes and modifications to the embodiments herein chosen for purposes of illustration will readily occur to those skilled in the art. For example, nanocrystals were described as being the storage elements for the memory cells but a possible alternative for the storage elements could be nanowires. To the extent that such modifications and variations do not depart from the spirit of the invention, they are intended to be included within the scope thereof which is assessed only by a fair interpretation of the following claims.

同族专利

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