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    专

    Tgf-r反义序列及其在制备抗气道炎症反应药物中的应用

    1261975895B2
    发明人
    ZHAO DEYU, LIU FENG, TIAN MAN, TANG HENG, LEI QIHONG, WANG QUAN, QIN HOUBING
    受让人
    NANJING CHILDREN S HOSPITAL AFFILIATED TO NANJING MEDICAL UNIVERSITY
    申请人
    Henry Chang
    申请号
    020336
    申请日
    1992-12-21
    公开(公告)号
    1261975895B2
    公开(公告)日
    2020-09-22
    IPC分类号
    A61N005/04A61B017/39A61B018/12A61N001/04A61B018/00
    CPC分类号
    -
    优先权号
    221374
    优先权日
    2003-12-03
    摘要

    NOVELTY - Preparation and isolation of betulin diacetate from birch bark involves grounding the birch bark, mixing with two- to twenty-fold excess volume of water, stirring, collecting the fraction of the birch bark which floats on the surface, drying the collected fraction at 50-85 degrees C, subjecting the betulin contained in the dried birch bark to an acetylation reaction, drying the birch bark at 50-100 degrees C, isolating the formed betulin diacetate from the birch bark by supercritical extraction, and subsequently recrystallizing.

    USE - For preparation and isolation of betulin diacetate from birch bark from paper mills and its optional further processing to betulin (claimed) useful in pharmaceutical and cosmetic industry and in chemical syntheses.

    ADVANTAGE - By using the method, it is possible to obtain betulin diacetate of high purity from the waste birch bark from paper mills on industrial scale in an ecologically and economically advantageous way, and by its hydrolysis it is possible to obtain betulin of high purity for use in pharmaceutical and cosmetic industry and in chemical syntheses.

    DETAILED DESCRIPTION - Preparation and isolation of betulin diacetate from birch bark from paper mills and its optional further processing to betulin, involves grounding the birch bark, mixing with two- to twenty-fold excess volume of water, stirring so that all birch bark is dipped, collecting the fraction of the birch bark which floats on the surface, drying the collected fraction at 50-85 degrees C, subjecting the betulin contained in the dried birch bark to an acetylation reaction, drying the birch bark at 50-100 degrees C, isolating the formed betulin diacetate from the birch bark by supercritical extraction of the birch bark with carbon dioxide at the pressure of 28-35 MPa and at 50-100 degrees C, and subsequently recrystallizing the supercritical extract for direct use or for further processing.

    权利要求
    1. A method for providing a User End device (UE) with access to a service provided by an Application Function (AF) via a network, the method comprising: authenticating the UE by a gateway to which the UE is attached; obtaining, by the gateway, a service flow request from the UE, wherein the gateway adds additional information to the service flow request; creating, by the gateway, a Network Address Translation (NAT) or Network Address and Port Translation (NAPT) binding for the UE; sending, by the gateway, information on the created NAT or NAPT binding to a state database (SDB), wherein the SDB is on a separate network from the network used by the AF to provide the service to the UE; sending, by the SDB, the information on the created NAT or NAPT binding, or a UE identifier corresponding to the information on the created NAT or NAPT binding, to the AF; forwarding, by the gateway, the service flow request to the AF via the network; correlating, by the AF, the service flow request with the UE based on the information on the created NAT or NAPT binding, or the UE identifier corresponding to the information on the created NAT or NAPT binding, from the SDB; and configuring, by the AF, in response to the correlating, a service flow corresponding to the service flow request with the UE for providing the service, wherein the configuring includes at least one of the following: (a) allowing the service to be set up, (b) allowing specific policies to be applied to the service, and (c) starting an accounting procedure.
    2. The method according to claim 1 , further comprising: based on the correlating, providing, by the AF, traffic to the UE based on at least one definable parameter.
    3. The method according to claim 1 , wherein the configuring includes providing the service to the authenticated UE without requiring a login from a subscriber corresponding to the UE if the SUB sends login/authentication data to the AF.
    4. The method according to claim 1 , wherein the gateway authenticates the UE by exchanging information with an entity that contains a user database and a profile.
    5. The method according to claim 4 , wherein with an authentication reply from the entity, the gateway receives a policy that instructs the gateway to inform the SDB regarding the service flow request.
    6. The method according to claim 1 , wherein forwarding the service flow request to the AF via the network is performed by the gateway after the AF has informed the gateway that the AF has received the information on the created NAT or NAPT binding, or the UE identifier corresponding to the information on the created NAT or NAPT binding, from the SDB.
    7. The method according to claim 1 , wherein the additional information is used by the AF to query the SDB to find out information needed for the service flow.
    8. The method according to claim 1 , wherein the SDB queries the gateway for NAT or NAPT bindings relating to other UEs attached to the gateway.
    9. The method according to claim 1 , wherein the AF is authenticated during its registration according to a business level agreement.
    10. The method according to claim 1 , wherein the UE transfers its access rights to another UE attached to the same gateway not having performed an authentication procedure.
    11. The method according to claim 10 , wherein the UE sends a message via an authentication channel to the gateway to bundle both UEs with regard to the UE identifier.
    12. A network system, wherein access to a service provided by an Application Function (AF) is provided to a User End device (UE) via a network, wherein the network system comprises: a gateway to which the UE is attached, configured to: authenticate the UE; obtain a service flow request from the UE, wherein the gateway is configured to add additional information to the service flow request; create a Network Address Translation (NAT) or Network Address and Port Translation (NAPT) binding for the UE; send information on the created NAT or NAPT binding to a state database (SDB); forwarding, by the gateway, the service flow request to the AF via the network; the SDB, configured to send the information on the created NAT or NAPT binding, or a UE identifier corresponding to the information on the created NAT or NAPT binding, to the AF, wherein the SDB is on a separate network from the network used by the AF to provide the service to the UE; the AF, configured to: correlate the service flow request with the UE based on the information on the created NAT or NAPT binding, or the UE identifier corresponding to the created NAT or NAPT binding information, from the SDB; and configure, in response to the correlating, a service flow corresponding to the service flow request with the UE for providing the service, wherein the configuring includes at least one of the following: (a) allowing the service to be set up, (b) allowing specific policies to be applied to the service, and (c) starting an accounting procedure.
    说明书
    [0001]FIELD
    [0002]The invention relates to nails and similar fasteners formed in integral series but easily separable. More specifically, the invention relates to attributes of belts of nails suitable for dispensing through a nail-feeding device that improves the overall workflow for the user.
    [0003]BACKGROUND
    [0004]Power nailing devices are known in the art. These use compressed air, gas, electrical energy or manual effort to set and drive a series of nails quickly. The nails are delivered from a magazine or other supply such as a coil of parallel nails connected by one or more wires welded to the nail shafts (a “nail strap” or “coil nails”).
    [0005]When a tool's supply of nails is exhausted, it must be replenished so that work can proceed. Fastener supplies are often heavy and bulky, so it is inconvenient to carry extras around a job site. But returning from a work area to a supply depot to obtain a refill interrupts a workflow and may force workers following the nailer's progress to wait as well. When several workers are “banging nails” on a project, interruptions to reload nail guns may significantly impact the work crew's efficiency.
    [0006]Furthermore, running a tool completely out of fasteners may result in the worker “dry firing” the tool, which can damage the tool, the material being fastened, or both.
    [0007]In this environment, a mechanism for alerting the worker that the tool will soon run out of fasteners, and/or that the last fastener in the magazine has been placed, may facilitate the operation of a more-efficient supply chain at the worksite. For example, when a worker's tool is running low on fasteners, an assistant “runner” may be dispatched to retrieve a refill, which can be brought back to the worker timely and loaded into the nail gun with reduced idle time and impact on other workers.
    [0008]SUMMARY
    [0009]In a fastening tool that uses consumable supplies sequentially from a magazine or other store of such fasteners, a visible characteristic of some of the fasteners is manipulated so that the worker using the tool can be informed of the approximate number of fasteners remaining in the tool. The visible characteristic may be a color of the fastener, a shape or another characteristic of the fastener, which is apparent to the user after a fastener is set. In a basic embodiment, the last fastener (or the last few fasteners) delivered from a supply are provided with a different-color surface. For example, the last few nails in a coil-nail strap may have colored heads (i.e., heads that are a different color from nails that are set earlier from the same strap). When the worker observes these visibly-different nails being dispensed, she can prepare for running out of nails by requesting that a refill strap be brought from stores thereof.
    [0010]BRIEF DESCRIPTION OF DRAWINGS FIG. 1 shows the final few nails of a strap of coil nails where an embodiment of the invention is in use. FIG. 2 shows a different type of fastener, also implementing an embodiment. FIG. 3 shows yet another type of fastener comprising an embodiment. FIG. 4 shows another different fastener comprising an embodiment. FIG. 5 shows another different fastener comprising an embodiment.
    [0011]DETAILED DESCRIPTION
    [0012]Embodiments of the invention alter a standard, prior-art fastener supply for a fastening tool such as a power nailer or stapler in a way that alerts the user of the tool when the number of fasteners remaining in the tool runs low. A straightforward way of accomplishing this alerting function is to alter a visible characteristic of the last fastener (or the last few fasteners) in a refill in a way that is apparent to the user after that fastener (or those fasteners) have been placed.
    [0013]FIG. 1 shows the last few nails in a roll of “coil nails,” or a “nail strap.” Individual nails are held together at a consistent angle and inter-nail spacing by welding wires 110 , 120 at suitable places along the shaft of each nail. Coil nails are adapted for use in a power nailer, which unrolls a spool or coil of such nails into the tool's chamber, and then sets each successive nail with a strike that drives the nail, breaking the welds to the wires in the process.
    [0014]Element 100 shows the last five nails in a coil ( 101 - 105 ). Nails 130 (and all the earlier-dispensed nails in the coil, which would lie to the left of the portion of the coil shown here) have a first visual appearance after driving into a workpiece. This visual appearance is represented by the uncolored nail heads. After nails 130 (and earlier-dispensed nails) are set, nails 140 are set. These have a second visual appearance after driving, indicated by the shaded nail heads. The user of the tool can distinguish nail heads 130 from nail heads 140 , and is thus alerted that the nail coil is almost exhausted. The final nail in the coil, 150 , has yet a third visual appearance, indicated by the black nail head. After this nail is driven, the tool is empty and the user should not attempt to fire it again.
    [0015]An embodiment can function with any fastening tool that places fasteners taken sequentially from a store, cache, unit, magazine or other supply of fasteners. A tool that places fasteners taken randomly from a hopper or the like is not suitable. Fasteners implementing an embodiment of the invention must have at least two visually-different appearances within one magazine of functionally-equivalent fasteners, and fasteners dispensed earlier from the magazine should have a first uniform appearance, which changes to the second uniform appearance at a predetermined point in the magazine (i.e., fastener appearance should not change from the first appearance to the second appearance and back to the first appearance within a single magazine).
    [0016]An embodiment may include two or more different fastener appearances, and the number of fasteners of each different appearance may vary. Preferably, the very last fastener in the magazine will be visually distinguishable from all other fasteners in the magazine, but an embodiment will function acceptably if the last few fasteners (e.g., the last five or ten fasteners) in the magazine are all visually identical.
    [0017]FIG. 2 shows another embodiment of the invention. At 200 , a magazine for an angled nailer is shown. Nails 16 through 220 are held parallel and at a suitable spacing for the tool mechanism by plastic rails 20 . This magazine may be inserted into the tool, and nails are set sequentially from left to right. According to an embodiment of the invention, nails 16 , which are dispensed first, have a first visual appearance (indicated by clear heads 210 ); while nails 220 , which are dispensed last, have a second visual appearance (indicated by shaded heads 230 ). Nails in the middle of the magazine (not shown in this Figure) may be similar to the first nails 16 , or may have an appearance different from both 16 and 220 .
    [0018]FIG. 3 shows another visually distinguishable fastener characteristic that may be used in an embodiment. In FIGS. 1 & 2 , the nail heads were differently colored. (The colors may be paint, stain, electrochemical anodizing, plastic covers, or other means of applying color.) In FIG. 3 , the sequence of nails 300 starts with round-headed nails 310 , while the very last nail dispensed from the magazine 320 has a square head 330 . The actual shape of the nail head is not significant to an embodiment; rather, the important characteristic is that earlier-set nails be visually distinguishable from later-set nails. Nail head shape is another way to accomplish the visual distinction.
    [0019]FIG. 4 shows another fastener form where an embodiment can be used. At 400 , a strip of flat, square-shaft nails is provided; each nail may be secured to its neighbors by a frangible adhesive or by incomplete severance from a piece of bulk stock. The power nailer's action simultaneously shears each nail apart from the rest of the strip and drives the nail into the workpiece. According to an embodiment, the first group of nails from the strip 410 have a first visual appearance, the second group of nails have a second, different visual appearance, and the final group of nails have a third, different visual appearance. When the user observes black-headed nails being driven, she knows that a refill will be needed soon.
    [0020]Finally, FIG. 5 shows another different fastener type, commonly known as a staple 500 . These fasteners have prongs at each lateral end of a bar; they are typically made by forming two 90° bends on a wire, and they are driven by a thin hammer strike along the back of the staple, which separates the staple from the strip and drives the prongs into the workpiece.
    [0021]In this embodiment, the last staples to be dispensed from strip 500 (indicated at 510 ) have a corrugated or wavy back portion, which is visually distinguishable from the smooth backs of earlier-dispensed staples. Again, when the user observes these corrugated-back staples being set, she knows that the stapler is almost empty.
    [0022]It is appreciated that colored fasteners (and fasteners having similar visually-distinguishable characteristics) are known in the art. For example, U.S. Patent Application Publication No. 2008/0260496 by Parmann describes nails for a pneumatic or electrical power nailer where each nail has a colored head. But Parmann's nails are all the same color—the purpose of the colored head is to assist in visually locating the nail after installation, for example for purposes of inspection. The color may also communicate the nail type or size, so that an inspector can confirm that the proper nail has been used in each location.
    [0023]Embodiments of the present invention use different colors (or other different, visually-distinguishable characteristics) on fasteners that are otherwise the same. Here, the different visual characteristic communicates useful information to the worker when the fastener is being placed.
    [0024]The applications of the present invention have been described largely by reference to specific examples and in terms of particular means of achieving visual distinguishability in fasteners such as nails and staples. However, those of skill in the art will recognize that the benefits of an embodiment can also be produced by fastener modifications that are visually distinguishable for other reasons than shape, color or texture. Such variations and implementations are understood to be captured according to the following claims.
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