ObjectiveThis study aims to assess the associations of complete blood cell count (CBC)-derived inflammatory biomarkers with the prevalence of asthma and mortality.MethodsData was collected from the 1999-2018 National Health and Nutrition Examination Survey (NHANES). Mortality was identified using the National Death Index until December 31, 2019. The study analyzed the relationship between CBC-derived inflammatory biomarkers, including neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio (MLR), systemic inflammatory response index (SIRI), and systemic immune-inflammation index (SII), and the prevalence of asthma using multiple logistic regressions. To assess the significance of CBC-derived inflammatory biomarkers in predicting all-cause and respiratory disease mortality in asthma patients, Cox proportional regressions and the random survival forest (RSF) analysis were utilized.ResultsA total of 48,305 participants were included, with a mean age of 47.27 ± 0.18 years and 49.44% male. Among them, 6,403 participants had asthma, with a prevalence of 13.28%. The all-cause and respiratory disease deaths at a median follow-up of 8.2 (4.5, 12.8) years were 929 and 137 respectively. After adjusting for confounders, the prevalence of asthma was found to be positively associated with NLR, PLR, MLR, SIRI and SII. Compared to the lowest quartile, the highest quartile of NLR (HR=1.765 [1.378-2.262]), MLR (HR=1.717 [1.316-2.241]), SIRI (HR=1.796 [1.353-2.383]) and SII (HR=1.432 [1.141-1.797]) were associated with an increased risk of all-cause mortality. These associations were more pronounced in respiratory disease mortality of asthma patients. RSF analysis showed that MLR had the highest predictive value for all-cause and respiratory disease mortality in adults with asthma. The sensitivity analysis demonstrated the stability of our results.ConclusionThe findings suggest that CBC-derived inflammatory biomarkers are associated with a higher risk of all-cause and respiratory disease mortality in adults with asthma.

目的 观察揿针联合常规抗心衰方案治疗阳气亏虚血瘀型慢性心力衰竭的疗效.方法 选取2021年1-12月在福建中医药大学附属康复医院门诊或住院治疗的阳气亏虚血瘀型慢性心力衰竭患者60例.按照随机数字表法分为对照组和治疗组各30例.对照组予常规抗心衰药物方案,治疗组在对照组治疗基础上联合揿针治疗,取穴:膻中、命门,内关(双)、心俞(双)、血海(双)、郄门(双)、足三里(双)、膈俞(双)、肾俞(双),48 h更换1次揿针,治疗10次.2组疗程均为20 d.比较2组左室舒张末期内径(LVEDD)、左心室收缩末内径(LVESD)、左室射血分数(LVEF)、C-反应蛋白(CRP)、血浆N末端B型利钠肽原(NT-proBNP)、血管紧张素Ⅱ(AngⅡ)、6分钟步行试验(6MWT)、明尼苏达生活质量问卷(MLHFQ)、中医证候疗效及不良反应情况.结果 与治疗前比较,2组治疗后LVEDD、LVESD、CRP、NT-proBNP、AngⅡ、MLHFQ较治疗前均下降,LVEF、6MWT较治疗前均升高,差异均有统计学意义(P＜0.05);与对照组比较,治疗组治疗后LVEDD、LVESD、CRP、NT-proBNP、AngⅡ、MLHFQ下降程度及LVEF、6MWT升高程度较对照组明显,差异均有统计学意义(P＜0.05);中医证候疗效比较,对照组总有效率66.67%,治疗组总有效率86.67%,差异具有统计学意义(P＜0.05).结论 揿针联合常规抗心衰方案可有效改善阳气亏虚血瘀型慢性心力衰竭患者心脏功能,提高其运动能力及改善生活质量,值得临床推广.

目的 观察六字诀对脑卒中后疲劳患者的疗效及气虚血瘀证候的影响.方法 选取2022年6月至2023年3月在福建中医药大学附属康复医院住院的脑卒中后疲劳患者68例,按照随机数字表分为治疗组和对照组各34例.对照组采用常规康复治疗与常规呼吸治疗,治疗组采用常规康复治疗与六字诀,30 min/次,1次/d,5 d/周,共进行12周.干预前后采用疲劳严重度量表(fatigue severity scale,FSS)、气虚血瘀证候要素诊断量表、呼吸困难程度分级[改良版的英国医学委员会量表(mMRC)]评分进行评估.结果 最终完成64例,其中治疗组32例,对照组32例.与干预前对比,两组干预后,治疗组FSS评分(2.875±0.707)分与气虚血瘀证候要素诊断量表评分(20.219±5.204)分、(14.656±3.488)分改善程度明 显优于 对照组(4.313±0.471 分)、(27.438±5.315)分、(22.313±4.432)分,差异有统计学意义(P＜0.05);两组mMRC评分均较治疗前降低,治疗组与对照组比较,差异无统计学意义(P＞0.05).结论 六字诀能够改善脑卒中后疲劳患者的疲劳严重度与气虚血瘀证候评分,改善患者的疲劳症状,且促进患者脏腑气血运行.

目的 观察八段锦联合有氧踏车训练的康复方案对慢性心力衰竭患者心肺功能的影响.方法 采用随机数字表法将60例慢性心力衰竭患者分为对照组和观察组,每组30例.对照组采取常规抗心衰治疗,观察组在对照组治疗基础上增加八段锦联合有氧踏车训练,2组均持续治疗12周.观察2组治疗前后左室舒张末内径(LVEDD)、左室射血分数(LVEF)、血浆N末端脑钠肽前体(NT-proBNP)、峰值摄氧量(PeakVO2)、代谢当量(MET)变化情况.结果 与治疗前比较,2组治疗后LVEDD、NT-proBNP均明显降低(P<0.05),LVEF、Peak?VO2、MET明显提高(P<0.05);与对照组比较,观察组治疗后LVEDD、NT-proBNP均明显降低(P<0.05),LVEF、PeakVO2、MET明显提高(P<0.05).结论 八段锦联合有氧踏车训练的康复方案可有效改善慢性心力衰竭患者心肺功能,值得临床推广.

Objective To investigate the effect of respiratory muscle stretch gymnastic in sitting position on pulmonary function and trunk function in convalescent stroke patients.Methods A total of 60 convalescent stroke patients who were hospitalized in the Affiliated Rehabilitation Hospital of Fujian University of Traditional Chinese Medicine from December2020 to December 2021 and met the criteria were selectedas research objects,the patients were divided into therapy group（n=30） and control group（n=30） according to random number table.The control group was treated with conventional rehabilitation combined with conentional respiratory therapy,the therapy group was treated with conventional rehabilitation combined with respiratory muscle stretch gymnastic.Forced vital capacity（FVC）,forced expiratory volume in the first second（FEV 1 ）,static sitting balance,dynamic sitting balance and coordination were compared between the two groups.Results After treatment,FVC,FEV 1 ,static sitting balance,dynamic sitting balance and coordination of two groups were higher than those before treatment,the differences were statistically significant（P＜0.05）.FVC,FEV 1 ,static sitting balance,dynamic sitting balance and coordination in the treatment group were higher than those in the control group,and the differences were statistically significant（P＜0.05）.Conclusion The application of respiratory muscle stretch gymnastic in the rehabilitation of convalescent stroke patients can better improve the pulmonary function and trunk function.

目的 分析针刺结合有氧运动的康复方案对慢性心力衰竭患者心肺储备能力的影响.方法 随机将2018年7月—2020年12月收治的60例慢性心力衰竭患者分为两组,各30例,对照组采取常规抗心力衰竭治疗,观察组在对照组基础上增加针刺结合有氧运动的康复干预,3个月后对比左室射血分数、心功能分级、明尼苏达心力衰竭生活质量调查表、峰值摄氧量、无氧代谢阈摄氧量、代谢当量、二氧化碳通气当量斜率等心肺储备能力的指标.结果 观察组患者左室射血分数、心功能分级、峰值摄氧量、无氧阈、代谢当量显著优于对照组.观察组明尼苏达心力衰竭生活质量评分、二氧化碳通气当量斜率差异有统计学意义(P<0.05).结论 针刺结合有氧运动的康复方案可改善慢性心力衰竭患者心肺储备能力、心功能及生活质量.

目的:探讨心肺一体化心脏康复治疗老年慢性心力衰竭的疗效.方法:选取福建中医药大学附属康复医院2018年10月至2021年1月所收治的老年慢性心力衰竭患者86例,随机分为观察组和对照组,每组43例.对照组仅予以内科常规抗心力衰竭治疗;观察组在对照组基础上加用心肺一体化心脏康复治疗,比较两组患者的疗效.结果:治疗前,两组患者的心功能各项指标比较,差异无统计学意义(P＞ 0.05);治疗后,观察组患者的左心室收缩末期内径(LVESD)、左心室舒张末期内径(LVEDD)、左心室收缩末期容量(LVESV)、左心室舒张末期容量(LVEDV)均低于对照组,左心室射血分数(LVEF)高于对照组,差异具有统计学意义(P＜0.05).治疗前,两组患者生活质量评分比较,差异无统计学意义(P＞0.05);治疗后,观察组患者评分高于对照组,差异具有统计学意义(P＜0.05).观察组患者不良反应发生率为9.30％,低于对照组的32.56％,差异具有统计学意义(P＜0.05).结论:心肺一体化心脏康复治疗有利于改善患者心功能、改善生活质量,还可以减少肺炎等不良事件发生,有利于保障预后质量.

目的 观察腹式呼吸康复训练联合噻托溴铵吸入治疗对慢性阻塞性肺疾病稳定期患者呼吸困难评分及肺功能的影响.方法 选取2017年10月-2019年10月福建中医药大学附属康复医院收治的慢性阻塞性肺疾病稳定期患者64例,采用随机数字表法分为研究组和对照组,每组32例.对照组采用噻托溴铵吸入治疗,研究组采用腹式呼吸康复训练联合噻托溴铵吸入治疗,比较2组治疗前后呼吸困难评分、肺功能[第1秒用力呼气容积(FEV1)、用力肺活量(FVC)、FEV1/FVC、FEV1占预计值百分比]及肿瘤坏死因子-α(TNF-α)水平.结果 治疗后,2组呼吸困难评分及TNF-α水平均低于治疗前,且研究组低于对照组(P<0.05);治疗后,2组FEV1、FVC、FEV1/FVC、FEV1占预计值百分比均高于治疗前,且研究组高于对照组(P<0.05).结论 腹式呼吸康复训练联合噻托溴铵吸入治疗慢性阻塞性肺疾病稳定期效果较好,可有效改善患者呼吸困难症状及肺功能,临床推广价值较高.

目的 分析八段锦运动对慢性心力衰竭患者心室重塑及心功能的影响.方法 随机将2018年12月-2019年11月收治的60例慢性心衰患者分为2组,各30例.对照组采取常规抗心衰治疗,观察组在对照组基础上加以八段锦训练干预,24周后对比心室重塑、心功能及心衰相关炎症因子指标.结果 观察组治疗后左室射血分数(LVEF)、左室收缩末期容积(LVESV)、左室舒张末期容积(LVEDV)分别为(51.6±2.7)％、(137.2±26.9)mL、(182.6±24.3)mL,较对照组的(49.6±1.7)％、(151.3±25.3)mL、(207.0±31.4)mL,差异有统计学意义(P＜0.05).观察组治疗后心衰相关炎性因子水平均较对照组慢性下降(P＜0.05).结论 八段锦运动干预能进一步改善慢性心衰患者心室重塑及心功能.

目的 观察温脾良附汤治疗脾胃虚寒型慢性萎缩性胃炎的临床效果.方法 选取2016年9月—2018年10月收治的脾胃虚寒型慢性萎缩性胃炎患者56例,采用随机数字表法分为对照组和观察组各28例.对照组予替普瑞酮治疗,观察组予温脾良附汤加减治疗.比较2组中医证候疗效、胃镜下黏膜病变的改善情况及治疗前后幽门螺杆菌(HP)转阴率.结果 观察组中医证候总有效率、胃镜下黏膜病变的改善总有效率、幽门螺杆菌(HP)转阴率明显高于对照组,2组比较差异有统计学意义(P<0.05).结论 温脾良附汤是治疗脾胃虚寒型慢性萎缩性胃炎的有效方剂.

目的 探讨在中医体质辨识基础上应用中医药综合治疗痰湿体质原发性高血压2级患者的临床疗效.方法 将60例属于痰湿体质的原发性高血压2级患者随机分为治疗组和对照组,治疗组在常规口服西药治疗的基础上应用中医药综合治疗,对照组采用常规口服西药治疗.结果 疗程结束后治疗组患者在降压效果上优于对照组(P＜0.05).结论 口服西药降压基础上应用中医药综合治疗干预可显著改善痰湿体质原发性高血压2级患者的健康问卷评分,提高降压效果.

稳定性心绞痛可用硝酸酯类、抗血小板聚集、他汀类药物治疗,本病属中医“胸痹”、“心痛”范畴.针灸治疗稳定性心绞痛疗效肯定,可有效缓解症状,改善心电图表现[1].我们在药物治疗基础上,用针刺合体外反搏治疗稳定性心绞痛患者30例,疗效较好,现报道如下.

Objective :Explore stick massage at the Neiguan acupoint improving the quality of life in patients with chest pain(coronary heart disease) .Methods :60 patients diagnosed with chest pain(coronary heart disease) were randomly di‐vided into test group(32 cases) and control group(28 cases) .The control group received routine medical care and nurs‐ing ,while the test group received both routine medical care ,nursing and stick massage at the Neiguan acupoint .The NT‐proBNP to evaluate the cardiac function ,modified Barthel Index to evaluate the activity of daily life and SF‐36 to e‐valuate the quality of life were tested before and after the treatment in both group .Results:After treatment ,the change of NT‐proBNP ,improvement of MBI and SF‐36 in test group were significantly better than those of control group (P<0 .05) .Conclusion:Stick massage at the Neiguan acupoint can improve the cardiac function and quality of life in patients with chest pain(coronary heart disease) .

目的 通过局部挑针配合远端针刺治疗神经根型颈椎病的临床对照研究,研究出一种更有效的方法.方法 将符合标准的80例研究对象,随机分为治疗组、对照组各40例,取穴均为颈部阳性反应水平的夹脊穴、大椎、中渚、外关等,分别采用局部挑针配合远端针刺、传统针刺法治疗,总共8次治疗,为期4周,通过NPQ、VAS量表进行疗效评价.结果 局部挑刺配合远端取穴组和传统针刺组均有疗效及远期效应,但前者优于后者.结论 局部挑针配合远端针刺组临床疗效好,远期效应好,值得推广.

目的：观察左归丸治疗阴虚阳亢型高血压的疗效。方法：将90例阴虚阳亢型高血压患者随机分为治疗组（45例）和对照组（45例），两组患者均给予服用苯磺酸氨氯地平（5mg，qd）治疗，治疗组则配合服用左归丸汤方，观察两组临床疗效。结果：治疗组总有效率为93.3%，显著高于对照组的80.0%（P<0.05）；治疗后，治疗组血压改善程度、症候积分降低程度均显著优于对照组（P<0.05）；两组均未出现明显不良反应。结论：左归丸可提高阴虚阳亢型高血压患者降压效果，且安全性高，值得临床推广应用。

ObjectiveObserve the curative effect of acupoint massage treatment of senile chronic functional constipation. Methods Randomly selected from 60 cases of elderly patients with chronic functional constipation, it can be divided into the treatment group and control group, 30 cases in each group. The control to the hollow drink weak brine or honey water, the treatment group on the basis of the control to the acupuncture point massage. ResultsThe curative effect of treatment group is better than that of control group, two groups of the effect of comparative differences statistically significant (P < 0.05).Conclusions Point massage for the treatment of chronic functional constipation curative effect, is worth promoting.

慢性阻塞性肺病(COPD)是一种慢性呼吸系统疾病,以气道不完全性可逆性气流受限为特征[1].本病急性加重期的频繁发作,导致病情恶化.COPD急性加重期以感染为主要原因,因此抗感染治疗至关重要.但是随着抗生素的使用,各种细菌的耐药性逐年增加,使得治疗效果不甚理想.近年来,我科采用中西医结合方法治疗COPD急性加重期痰热症患者102例,临床效果满意,现将结果报告如下.

病毒性心肌炎(viralmyocarditis,VMC)是指嗜心肌性病毒感染引起的以心肌非特异性间质性炎症为主要病变的心肌炎.病毒性心肌炎是常见的心血管疾病之一,其发病机制尚未完全明确,目前尚无特异的治疗方法.近年来大量研究表明多种中药对病毒性心肌炎有良好的治疗作用,对其作用机制的研究也较为全面,中药现已成为治疗病毒性心肌炎的重要药物.